M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular easy muscle cells throughout vascular tissue restore after intravascular stent implantation
Rationale: For intravascular stent implantation to achieve success, the processes of vascular tissue restore and remedy are thought-about to be vital. Nonetheless, the mechanisms underlying the eventual destiny of vascular easy muscle cells (VSMCs) throughout vascular tissue restore stays elusive. On this examine, we hypothesized that M2 macrophage-derived exosomes to mediate cell-to-cell crosstalk and induce dedifferentiation phenotypes in VSMCs.
Strategies: In vivo, 316L naked steel stents (BMS) had been implanted from the left iliac artery into the belly aorta of 12-week-old male Sprague-Dawley (SD) rats for 7 and 28 days. Hematoxylin and eosin (HE) had been used to stain the neointimal lesions. En-face immunofluorescence staining of easy muscle 22 alpha (SM22α) and CD68 confirmed the rat aorta easy muscle cells (RASMCs) and macrophages. Immunohistochemical staining of complete galactose-specific lectin 3 (MAC-2) and complete chitinase 3-like 3 (YM-1) confirmed the overall macrophages and M2 macrophages.
In vitro, exosomes derived from IL-4+IL-13-treated macrophages (M2Es) had been remoted by ultracentrifugation and characterised based mostly on their particular morphology. Ki-67 staining was carried out to evaluate the consequences of the M2Es on the proliferation of RASMCs. An atomic pressure microscope (AFM) was used to detect the stiffness of the VSMCs. GW4869 was used to inhibit exosome launch. RNA-seq was carried out to find out the mRNA profiles of the RASMCs and M2Es-treated RASMCs. Quantitative real-time PCR (qRT-PCR) evaluation was carried out to detect the expression ranges of the mRNAs. Western blotting was used to detect the candidate protein expression ranges. T-5224 was used to inhibit the DNA binding exercise of AP-1 in RASMCs.
Outcomes: M2Es promote c-KIT expression and softening of close by VSMCs, therefore accelerating the vascular tissue restore course of. VSMCs co-cultured in vitro with M2 macrophages introduced an elevated capability for de-differentiation and softening, which was exosome dependent. As well as, the remoted M2Es helped to advertise VSMC dedifferentiation and softening.
Moreover, the M2Es enhanced vascular tissue restore efficiency by upregulation of VSMCs c-KIT expression through activation of the c-Jun/activator protein 1 (AP-1) signaling pathway.
Conclusions: The findings of this examine emphasize the distinguished position of M2Es throughout VSMC dedifferentiation and vascular tissue restore through activation of the c-Jun/AP-1 signaling pathway, which has a profound impression on the therapeutic methods of coronary stenting methods.

ataxin
Leukemia - CLL Exosome RNA |
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P241-CLL | 101Bio | - | Ask for price |
Leukemia - CML Exosome RNA |
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P241-CML | 101Bio | - | Ask for price |
Leukemia - Hairy Cell Exosome RNA |
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P241-HC | 101Bio | - | Ask for price |
Leukemia - Multiple Myeloma Exosome RNA |
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P241-MM | 101Bio | - | Ask for price |
pReceiver-Lv105-AML-1B Plasmid |
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PVTB00282S | Lifescience Market | 2 ug | EUR 427.2 |
ReadiCleave™ AML Cy5 NHS ester |
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7000 | AAT Bioquest | 1 mg | EUR 446 |
ReadiCleave™ XFD532 AML-NHS ester |
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7001 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave™ ROXtra AML-NHS ester |
|||
7002 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave™ FITC AML-NHS ester |
|||
7004 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave® XFD488 AML-NHS ester |
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7008 | AAT Bioquest | 1 mg | EUR 403 |
ReadiCleave® XFD546 AML-NHS ester |
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7009 | AAT Bioquest | 1 mg | EUR 403 |
Aqueous Mount (Low Viscosity) |
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AML-10000 | ScyTek Laboratories | 10 L | EUR 2499.6 |
Psoriasis Exosome |
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P141-PS | 101Bio | - | Ask for price |
ReadiCleave™ iFluor 700 AML-NHS ester |
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7003 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave™ iFluor 488 AML-NHS ester |
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7005 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave™ iFluor 546 AML-NHS ester |
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7006 | AAT Bioquest | 1 mg | EUR 412 |
ReadiCleave™ iFluor 594 AML-NHS ester |
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7007 | AAT Bioquest | 1 mg | EUR 412 |
Exosome precipitation Solution |
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EPStep | ImmunoStep | 12 ml | EUR 333 |
Bladder Cancer Exosome |
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P141-BL | 101Bio | - | Ask for price |
Breast Cancer Exosome |
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P141-BR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome |
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P141-CO | 101Bio | - | Ask for price |
Crohn's Disease Exosome |
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P141-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome |
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P141-KN | 101Bio | - | Ask for price |
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P141-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome |
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P141-LV | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome |
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P141-NA | 101Bio | - | Ask for price |
Prostate Cancer Exosome |
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P141-PR | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome |
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P141-RA | 101Bio | - | Ask for price |
Thyroid Cancer Exosome |
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P141-TH | 101Bio | - | Ask for price |
Lyophilized Exosome Standards |
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ExoA375 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
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ExoHT29 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
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ExoMCF7 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
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ExoPC3 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
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ExoPLASMA | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
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ExoUrine | ImmunoStep | 100 μg | EUR 364.2 |
Psoriasis Exosome RNA |
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P241-PS | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS) |
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P101NGS | 101Bio | - | Ask for price |
Bovine Leukemia Virus(Leukemia Virus) |
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QY-E60121 | Qayee Biotechnology | 96T | EUR 511.2 |
Exosome Component 9 Peptide |
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46-967P | ProSci | 0.1 mg | EUR 405.6 |
Description: (CT) PMSCL1 Peptide |
Exosome Component 3 Protein |
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20-abx263422 | Abbexa |
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Exosome Component 1 Protein |
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20-abx263423 | Abbexa |
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Exosome Component 5 Protein |
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20-abx260873 | Abbexa |
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Exosome Component 7 Protein |
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20-abx261347 | Abbexa |
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Exosome Component 10 Protein |
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20-abx261805 | Abbexa |
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Exosome Component 4 Protein |
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20-abx261954 | Abbexa |
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Exosome Component 9 Protein |
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20-abx262123 | Abbexa |
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Exosome Component 8 Protein |
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20-abx262850 | Abbexa |
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Exosome-TEM-easy Kit |
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P130 | 101Bio | - | Ask for price |
Diabetes (Type 1) Exosome |
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P141-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome |
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P141-DB2 | 101Bio | - | Ask for price |
Melanoma (skin cancer) Exosome |
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P141-MN | 101Bio | - | Ask for price |
Non-Hodgkin lymphoma Exosome |
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P141-NH | 101Bio | - | Ask for price |
Systemic Lupus Erythematosus Exosome |
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P141-SL | 101Bio | - | Ask for price |
Uterine Cervical Cancer Exosome |
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P141-UC | 101Bio | - | Ask for price |
Uterine Corpus Cancer Exosome |
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P141-UT | 101Bio | - | Ask for price |
EXOCET Exosome Quantitation Kit |
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EXOCET96A-1 | SBI | 96 reactions | EUR 625.2 |
Fluorescent Exosome Standard (Urine ) |
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ESF-15 | Creative Biolabs | 100 µg | EUR 2067.6 |
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling. |
FluoroCet Exosome Quantitation Kit |
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FCET96A-1 | SBI | 96 reactions | EUR 871.2 |
Normal human exosome RNA |
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P240 | 101Bio | - | Ask for price |
Bladder Cancer Exosome RNA |
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P241-BL | 101Bio | - | Ask for price |
Breast Cancer Exosome RNA |
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P241-BR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome RNA |
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P241-CO | 101Bio | - | Ask for price |
Crohn's Disease Exosome RNA |
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P241-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome RNA |
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P241-KN | 101Bio | - | Ask for price |
Lung Cancer Exosome RNA |
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P241-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome RNA |
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P241-LV | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome RNA |
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P241-NA | 101Bio | - | Ask for price |
Prostate Cancer Exosome RNA |
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P241-PR | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome RNA |
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P241-RA | 101Bio | - | Ask for price |
Thyroid Cancer Exosome RNA |
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P241-TH | 101Bio | - | Ask for price |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-601-10um | ProSci | 10 um | EUR 241.8 |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-601-4um | ProSci | 4 um | EUR 216.6 |
ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome) |
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P402 | 101Bio | - | Ask for price |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-606-10um | ProSci | 10 um | EUR 241.8 |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-606-4um | ProSci | 4 um | EUR 216.6 |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) |
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P101EZ | 101Bio | - | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05902 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05903 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05904 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05905 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05906 | CHI Scientific | 20µg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05907 | CHI Scientific | 1mg | Ask for price |
Exosome Component 8 (EXOSC8) Antibody |
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20-abx003377 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx003412 | Abbexa |
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Exosome Component 7 (EXOSC7) Antibody |
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20-abx124556 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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20-abx124664 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx125829 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx125830 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx125831 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx112409 | Abbexa |
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Exosome Component 10 (EXOSC10) Antibody |
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20-abx112410 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx112411 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx112412 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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20-abx112413 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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20-abx112414 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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20-abx112415 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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abx034983-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 2 (EXOSC2) Antibody |
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abx034983-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 4 (EXOSC4) Antibody |
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abx029390-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 4 (EXOSC4) Antibody |
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abx029390-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 1 (EXOSC1) Antibody |
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abx030303-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 1 (EXOSC1) Antibody |
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abx030303-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 8 (EXOSC8) Antibody |
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abx031706-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 8 (EXOSC8) Antibody |
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abx031706-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 10 (EXOSC10) Antibody |
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20-abx334343 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx301763 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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20-abx302857 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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20-abx318649 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx312069 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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abx232898-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 10 (EXOSC10) Antibody |
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abx232899-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 10 (EXOSC10) Antibody |
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abx232900-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 2 (EXOSC2) Antibody |
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abx232901-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
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abx232902-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 3 (EXOSC3) Antibody |
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abx232903-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 4 (EXOSC4) Antibody |
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abx232904-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 5 (EXOSC5) Antibody |
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abx232905-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 7 (EXOSC7) Antibody |
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abx232906-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 8 (EXOSC8) Antibody |
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abx232907-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 9 (EXOSC9) Antibody |
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abx232908-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosomes derived from human amniotic epithelial cells speed up diabetic wound therapeutic through PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast operate
Background: Diabetic wounds are one of the vital widespread and severe problems of diabetes mellitus, characterised by the dysfunction of wound-healing-related cells in amount and high quality. Our earlier research revealed that human amniotic epithelial cells (hAECs) might promote diabetic wound therapeutic by paracrine motion.
Apparently, quite a few research demonstrated that exosomes derived from stem cells are the vital paracrine autos for stem cell remedy. Nonetheless, whether or not exosomes derived from hAECs (hAECs-Exos) mediate the consequences of hAECs on diabetic wound therapeutic stays unclear. This examine aimed to research the organic results of hAECs-Exos on diabetic wound therapeutic and preliminarily elucidate the underlying mechanism.
Strategies: hAECs-Exos had been remoted by ultracentrifugation and recognized by transmission electron microscopy, dynamic mild scattering and circulation cytometry. A collection of in vitro useful analyses had been carried out to evaluate the regulatory results of hAECs-Exos on human fibroblasts (HFBs) and human umbilical vein endothelial cells (HUVECs) in a high-glycemic microenvironment. Excessive-throughput sequencing and bioinformatics analyses had been carried out to invest the associated mechanisms of actions of hAECs-Exos on HFBs and HUVECs. Subsequently, the position of the candidate signaling pathway of hAECs-Exos in regulating the operate of HUVECs and HFBs, in addition to in diabetic wound therapeutic, was assessed.
Outcomes: hAECs-Exos introduced a cup- or sphere-shaped morphology with a imply diameter of 105.89 ± 10.36 nm, had been constructive for CD63 and TSG101 and may very well be internalized by HFBs and HUVECs. After that, hAECs-Exos not solely considerably promoted the proliferation and migration of HFBs, but in addition facilitated the angiogenic exercise of HUVECs in vitro.
Excessive-throughput sequencing revealed enriched miRNAs of hAECs-Exos concerned in wound therapeutic. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have proven that the goal genes of the highest 15 miRNAs had been extremely enriched within the PI3K-AKT pathway. Additional useful research demonstrated that the PI3K-AKT-mTOR pathway was mandatory for the induced organic results of hAECs-Exos on HFBs and HUVECs, in addition to on wound therapeutic, in diabetic mice.
Conclusions: Our findings demonstrated that hAECs-Exos signify a promising, novel technique for diabetic wound therapeutic by selling angiogenesis and fibroblast operate through activation of the PI3K-AKT-mTOR pathway.
Leukemia - AML Exosome RNA |
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P241-AML | 101Bio | - | Ask for price |
Leukemia - CLL Exosome RNA |
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P241-CLL | 101Bio | - | Ask for price |
General Carboxymethyl Lysine (CML) ELISA Kit |
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RD-CML-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 703.2 |
General Carboxymethyl Lysine (CML) ELISA Kit |
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RD-CML-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 979.2 |
General Carboxymethyl Lysine (CML) ELISA Kit |
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RDR-CML-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 735.6 |
General Carboxymethyl Lysine (CML) ELISA Kit |
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RDR-CML-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 1024.8 |
Leukemia - Hairy Cell Exosome RNA |
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P241-HC | 101Bio | - | Ask for price |
Leukemia - Multiple Myeloma Exosome RNA |
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P241-MM | 101Bio | - | Ask for price |
CML-BSA Control |
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STA-314 | Cell Biolabs | 100 µg | EUR 386.4 |
Description:
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Carboxymethyl Lysine (CML) Antibody |
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abx023261-1mg | Abbexa | 1 mg | EUR 1296 |
Porcine CML ELISA Kit |
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EPC0780 | Abclonal | 96Tests | EUR 625.2 |
Rabbit CML ELISA Kit |
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ERTC0780 | Abclonal | 96Tests | EUR 625.2 |
Rat CML ELISA Kit |
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ERC0780 | Abclonal | 96Tests | EUR 625.2 |
Mouse CML ELISA Kit |
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EMC0780 | Abclonal | 96Tests | EUR 625.2 |
Monkey CML ELISA Kit |
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EMKC0780 | Abclonal | 96Tests | EUR 625.2 |
Human CML ELISA Kit |
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EHC0780 | Abclonal | 96Tests | EUR 625.2 |
CML ELISA KIT|Human |
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EF007324 | Lifescience Market | 96 Tests | EUR 826.8 |
Goat CML ELISA Kit |
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EGTC0780 | Abclonal | 96Tests | EUR 625.2 |
Canine CML ELISA Kit |
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ECC0780 | Abclonal | 96Tests | EUR 625.2 |
Chicken CML ELISA Kit |
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ECKC0780 | Abclonal | 96Tests | EUR 625.2 |
Anserini CML ELISA Kit |
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EAC0780 | Abclonal | 96Tests | EUR 625.2 |
Bovine CML ELISA Kit |
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EBC0780 | Abclonal | 96Tests | EUR 625.2 |
Sheep CML ELISA Kit |
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ESC0780 | Abclonal | 96Tests | EUR 625.2 |
Psoriasis Exosome |
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P141-PS | 101Bio | - | Ask for price |
Carboxymethyl Lysine (CML) ELISA Kit |
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20-abx150327 | Abbexa |
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Carboxymethyl Lysine (CML) CLIA Kit |
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20-abx490445 | Abbexa |
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Guinea Pig CML ELISA Kit |
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EGC0780 | Abclonal | 96Tests | EUR 625.2 |
Carboxymethyl Lysine (CML) ELISA Kit |
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E4634-100 | Biovision | EUR 874.8 |
K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk) |
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HCLS-17004 | Alpha Diagnostics | 1 pk | EUR 300 |
Exosome precipitation Solution |
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EPStep | ImmunoStep | 12 ml | EUR 333 |
Bladder Cancer Exosome |
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P141-BL | 101Bio | - | Ask for price |
Breast Cancer Exosome |
|||
P141-BR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome |
|||
P141-CO | 101Bio | - | Ask for price |
Crohn's Disease Exosome |
|||
P141-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome |
|||
P141-KN | 101Bio | - | Ask for price |
Lung Cancer Exosome |
|||
P141-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome |
|||
P141-LV | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome |
|||
P141-NA | 101Bio | - | Ask for price |
Prostate Cancer Exosome |
|||
P141-PR | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome |
|||
P141-RA | 101Bio | - | Ask for price |
Thyroid Cancer Exosome |
|||
P141-TH | 101Bio | - | Ask for price |
Lyophilized Exosome Standards |
|||
ExoA375 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
ExoHT29 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
ExoMCF7 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
ExoPC3 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
ExoPLASMA | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
ExoUrine | ImmunoStep | 100 μg | EUR 364.2 |
Psoriasis Exosome RNA |
|||
P241-PS | 101Bio | - | Ask for price |
N(6)-Carboxymethyllysine (CML) ELISA Kit |
|||
abx575945-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Carboxymethyl lysine,CML ELISA Kit |
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201-12-1414 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Carboxymethyl lysine, CML ELISA Kit |
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CSB-E12798h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Carboxymethyl lysine, CML in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Carboxymethyl lysine, CML ELISA Kit |
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1-CSB-E12798h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Carboxymethyl lysine, CML in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
General Carboxymethyl Lysine (CML) ELISA Kit |
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CEB977Ge-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 6526.03 |
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids. |
General Carboxymethyl Lysine (CML) ELISA Kit |
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CEB977Ge-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 642.61 |
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids. |
General Carboxymethyl Lysine (CML) ELISA Kit |
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CEB977Ge-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 866.59 |
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids. |
General Carboxymethyl Lysine (CML) ELISA Kit |
|||
CEB977Ge-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3539.66 |
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids. |
General Carboxymethyl Lysine (CML) ELISA Kit |
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4-CEB977Ge | Cloud-Clone |
|
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General Carboxymethyl Lysine (CML) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human CML(Carboxymethyl Lysine) ELISA Kit |
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EH4116 | FN Test | 96T | EUR 628.92 |
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.4 ng/ml |
Human Carboxymethyl lysine(CML)ELISA Kit |
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GA-E1430HM-48T | GenAsia Biotech | 48T | EUR 346.8 |
Human Carboxymethyl lysine(CML)ELISA Kit |
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GA-E1430HM-96T | GenAsia Biotech | 96T | EUR 559.2 |
General Carboxymethyl Lysine ELISA Kit (CML) |
|||
RK00635 | Abclonal | 96 Tests | EUR 625.2 |
Human Carboxymethyl lysine(CML)ELISA Kit |
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QY-E01351 | Qayee Biotechnology | 96T | EUR 433.2 |
Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS) |
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P101NGS | 101Bio | - | Ask for price |
Bovine Leukemia Virus(Leukemia Virus) |
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QY-E60121 | Qayee Biotechnology | 96T | EUR 511.2 |
Exosome Component 9 Peptide |
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46-967P | ProSci | 0.1 mg | EUR 405.6 |
Description: (CT) PMSCL1 Peptide |
Exosome Component 3 Protein |
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20-abx263422 | Abbexa |
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Exosome Component 1 Protein |
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20-abx263423 | Abbexa |
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Exosome Component 5 Protein |
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20-abx260873 | Abbexa |
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Exosome Component 7 Protein |
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20-abx261347 | Abbexa |
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Exosome Component 10 Protein |
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20-abx261805 | Abbexa |
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Exosome Component 4 Protein |
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20-abx261954 | Abbexa |
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Exosome Component 9 Protein |
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20-abx262123 | Abbexa |
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Exosome Component 8 Protein |
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20-abx262850 | Abbexa |
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Exosome-TEM-easy Kit |
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P130 | 101Bio | - | Ask for price |
Diabetes (Type 1) Exosome |
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P141-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome |
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P141-DB2 | 101Bio | - | Ask for price |
Melanoma (skin cancer) Exosome |
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P141-MN | 101Bio | - | Ask for price |
Non-Hodgkin lymphoma Exosome |
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P141-NH | 101Bio | - | Ask for price |
Systemic Lupus Erythematosus Exosome |
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P141-SL | 101Bio | - | Ask for price |
Uterine Cervical Cancer Exosome |
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P141-UC | 101Bio | - | Ask for price |
Uterine Corpus Cancer Exosome |
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P141-UT | 101Bio | - | Ask for price |
EXOCET Exosome Quantitation Kit |
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EXOCET96A-1 | SBI | 96 reactions | EUR 625.2 |
Fluorescent Exosome Standard (Urine ) |
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ESF-15 | Creative Biolabs | 100 µg | EUR 2067.6 |
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling. |
FluoroCet Exosome Quantitation Kit |
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FCET96A-1 | SBI | 96 reactions | EUR 871.2 |
Normal human exosome RNA |
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P240 | 101Bio | - | Ask for price |
Bladder Cancer Exosome RNA |
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P241-BL | 101Bio | - | Ask for price |
Breast Cancer Exosome RNA |
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P241-BR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome RNA |
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P241-CO | 101Bio | - | Ask for price |
Crohn's Disease Exosome RNA |
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P241-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome RNA |
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P241-KN | 101Bio | - | Ask for price |
Lung Cancer Exosome RNA |
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P241-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome RNA |
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P241-LV | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome RNA |
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P241-NA | 101Bio | - | Ask for price |
Prostate Cancer Exosome RNA |
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P241-PR | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome RNA |
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P241-RA | 101Bio | - | Ask for price |
Thyroid Cancer Exosome RNA |
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P241-TH | 101Bio | - | Ask for price |
Bovine N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019b | Lifescience Market | 96 Tests | EUR 1113.6 |
Chicken N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019c | Lifescience Market | 96 Tests | EUR 1113.6 |
Canine N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019d | Lifescience Market | 96 Tests | EUR 1113.6 |
General N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019Ge | Lifescience Market | 96 Tests | EUR 1063.2 |
Human N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019m | Lifescience Market | 96 Tests | EUR 1038 |
Porcine N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019p | Lifescience Market | 96 Tests | EUR 1113.6 |
Rat N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019r | Lifescience Market | 96 Tests | EUR 1063.2 |
Rabbit N(6)- Carboxymethyllysine, CML ELISA Kit |
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CELI-66019Rb | Lifescience Market | 96 Tests | EUR 1113.6 |
General CML/ N(6)-Carboxymethyllysine ELISA Kit |
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E0014Ge | Sunlong | 1 Kit | EUR 860.4 |
ELISA kit for General CML (Carboxymethyl Lysine) |
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ELK7896 | ELK Biotech | 1 plate of 96 wells | EUR 446.4 |
Description: A competitive Inhibition ELISA kit for detection of Carboxymethyl Lysine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
General N(6)- Carboxymethyllysine, CML ELISA KIT |
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ELI-06348Ge | Lifescience Market | 96 Tests | EUR 1063.2 |
Goat Anti-N-epsilon-CML Polyclonal Antibody |
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STA-013 | Cell Biolabs | 100 µg | EUR 609.6 |
Description: Goat Anti-CML Polyclonal Antibody is Affinity purified and suitable for Western blot or ELISA. Suitable for use with any species. 100 µg. |
Rabbit Anti-N-epsilon-CML Polyclonal Antibody |
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STA-014 | Cell Biolabs | 100 µg | EUR 609.6 |
Description: Rabbit Anti-CML Polyclonal Antibody is Affinity purified and suitable for Western blot or ELISA. Suitable for use with any species. 100 µg. |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-601-10um | ProSci | 10 um | EUR 241.8 |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-601-4um | ProSci | 4 um | EUR 216.6 |
ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome) |
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P402 | 101Bio | - | Ask for price |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-606-10um | ProSci | 10 um | EUR 241.8 |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
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11-606-4um | ProSci | 4 um | EUR 216.6 |
CML ELISA Kit| Mouse Carboxymethyl Lysine ELISA Kit |
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EF014018 | Lifescience Market | 96 Tests | EUR 826.8 |
CML ELISA Kit| Rat Carboxymethyl Lysine ELISA Kit |
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EF018173 | Lifescience Market | 96 Tests | EUR 826.8 |
Anti CML Monoclonal Antibody (Clone No. CMS-10) |
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KH011 | Sceti | EUR 856.8 | |
Description: The Anti CML Monoclonal Antibody (Clone No. CMS-10) is available in Europe and for worldwide shipping via Gentaur. |
Anti CML Monoclonal Antibody (Clone No. NF-1G) |
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KH024 | Sceti | EUR 856.8 | |
Description: The Anti CML Monoclonal Antibody (Clone No. NF-1G) is available in Europe and for worldwide shipping via Gentaur. |
ELISA kit for Rat N(6)-Carboxymethyllysine (CML) |
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KTE101082-48T | Abbkine | 48T | EUR 424.8 |
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat N(6)-Carboxymethyllysine (CML) |
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KTE101082-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2702.4 |
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat N(6)-Carboxymethyllysine (CML) |
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KTE101082-96T | Abbkine | 96T | EUR 686.4 |
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
OxiSelect N-epsilon-(Carboxymethyl) Lysine (CML) Immunoblot Kit |
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STA-313 | Cell Biolabs | 10 blots | EUR 637.2 |
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Immunoblot kit specifically detects CML formation in protein samples. |
OxiSelect N?-(carboxymethyl) lysine (CML) Competitive ELISA Kit |
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STA-816 | Cell Biolabs | 96 assays | EUR 957.6 |
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Competitive ELISA kit specifically detects CML formation with a high level of sensitivity. This is a Competitive ELISA Kit in which the plate is coated with a CML conjugate. Standards and unknown samples are added to the plate, followed by incubation with the primary antibody. The CML in the unknown samples and the CML attached to the plate compete for the primary antibody. Higher CML content in unknown samples results in more binding of the antibody to the sample, and thus less antibody binds to the plate. Since the antibody bound to the sample is washed away, higher CML content in samples correlates with a lower signal. |
OxiSelect N?-(carboxymethyl) lysine (CML) Competitive ELISA Kit |
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STA-816-5 | Cell Biolabs | 5 x 96 assays | EUR 3888 |
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Competitive ELISA kit specifically detects CML formation with a high level of sensitivity. This is a Competitive ELISA Kit in which the plate is coated with a CML conjugate. Standards and unknown samples are added to the plate, followed by incubation with the primary antibody. The CML in the unknown samples and the CML attached to the plate compete for the primary antibody. Higher CML content in unknown samples results in more binding of the antibody to the sample, and thus less antibody binds to the plate. Since the antibody bound to the sample is washed away, higher CML content in samples correlates with a lower signal. |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) |
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P101EZ | 101Bio | - | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05902 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05903 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Exosome Component 9 |
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7-05904 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05905 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05906 | CHI Scientific | 20µg | Ask for price |
Recombinant Human Exosome Component 10 |
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7-05907 | CHI Scientific | 1mg | Ask for price |
Exosome Component 8 (EXOSC8) Antibody |
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20-abx003377 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx003412 | Abbexa |
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Exosome Component 7 (EXOSC7) Antibody |
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20-abx124556 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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20-abx124664 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx125829 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx125830 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx125831 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx112409 | Abbexa |
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Exosome Component 10 (EXOSC10) Antibody |
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20-abx112410 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx112411 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx112412 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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20-abx112413 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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20-abx112414 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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20-abx112415 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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abx034983-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 2 (EXOSC2) Antibody |
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abx034983-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 4 (EXOSC4) Antibody |
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abx029390-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 4 (EXOSC4) Antibody |
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abx029390-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 1 (EXOSC1) Antibody |
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abx030303-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 1 (EXOSC1) Antibody |
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abx030303-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 8 (EXOSC8) Antibody |
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abx031706-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 8 (EXOSC8) Antibody |
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abx031706-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 10 (EXOSC10) Antibody |
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20-abx334343 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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20-abx301763 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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20-abx302857 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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20-abx318649 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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20-abx312069 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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abx232898-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 10 (EXOSC10) Antibody |
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abx232899-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 10 (EXOSC10) Antibody |
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abx232900-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 2 (EXOSC2) Antibody |
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abx232901-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
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abx232902-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 3 (EXOSC3) Antibody |
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abx232903-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 4 (EXOSC4) Antibody |
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abx232904-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 5 (EXOSC5) Antibody |
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abx232905-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 7 (EXOSC7) Antibody |
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abx232906-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 8 (EXOSC8) Antibody |
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abx232907-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 9 (EXOSC9) Antibody |
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abx232908-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 2 (EXOSC2) Antibody |
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20-abx172308 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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20-abx176346 | Abbexa |
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Exosome precipitation from Plasma + Thrombin |
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EPStep-T | ImmunoStep | 5 ml | EUR 403.2 |
ExoStd? Plasma Fluorescent Exosome Standard |
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M1073-100 | Biovision | EUR 907.2 |
ExoStd? Serum Fluorescent Exosome Standard |
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M1074-100 | Biovision | EUR 907.2 |
ExoStd? Urine Fluorescent Exosome Standard |
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M1075-100 | Biovision | EUR 907.2 |
ExoStd? Saliva Fluorescent Exosome Standard |
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M1076-100 | Biovision | EUR 907.2 |
ExoStd? COLO1 Fluorescent Exosome Standard |
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M1077-100 | Biovision | EUR 907.2 |
ExoStd? MM1 Fluorescent Exosome Standard |
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M1078-100 | Biovision | EUR 907.2 |
ExoStd? BLCL21 Fluorescent Exosome Standard |
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M1079-100 | Biovision | EUR 907.2 |
ExoStd? HCT116 Fluorescent Exosome Standard |
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M1083-100 | Biovision | EUR 907.2 |
ExoStd? PC3 Fluorescent Exosome Standard |
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M1086-100 | Biovision | EUR 907.2 |
ExoStd? DAUD1 Fluorescent Exosome Standard |
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M1088-100 | Biovision | EUR 907.2 |
ExoStd? A549 Fluorescent Exosome Standard |
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M1089-100 | Biovision | EUR 907.2 |
ExoStd? B16F10 Fluorescent Exosome Standard |
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M1159-100 | Biovision | EUR 927.6 |
Exosome Isolation kit (for urine) |
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P120L | 101Bio | - | Ask for price |
Exosome Isolation kit (for urine) |
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P120S | 101Bio | - | Ask for price |
LiqBiopsy Tumor Exosome RNA Kit |
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K1254-24 | Biovision | EUR 1332 |
Exo-Fect Exosome Transfection Kit |
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EXFT10A-1 | SBI | 10 reactions | EUR 351.6 |
Exo-Fect Exosome Transfection Kit |
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EXFT20A-1 | SBI | 20 reactions | EUR 586.8 |