M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular easy muscle cells throughout vascular tissue restore after intravascular stent implantation
Rationale: For intravascular stent implantation to achieve success, the processes of vascular tissue restore and remedy are thought-about to be vital. Nonetheless, the mechanisms underlying the eventual destiny of vascular easy muscle cells (VSMCs) throughout vascular tissue restore stays elusive. On this examine, we hypothesized that M2 macrophage-derived exosomes to mediate cell-to-cell crosstalk and induce dedifferentiation phenotypes in VSMCs.
Strategies: In vivo, 316L naked steel stents (BMS) had been implanted from the left iliac artery into the belly aorta of 12-week-old male Sprague-Dawley (SD) rats for 7 and 28 days. Hematoxylin and eosin (HE) had been used to stain the neointimal lesions. En-face immunofluorescence staining of easy muscle 22 alpha (SM22α) and CD68 confirmed the rat aorta easy muscle cells (RASMCs) and macrophages. Immunohistochemical staining of complete galactose-specific lectin 3 (MAC-2) and complete chitinase 3-like 3 (YM-1) confirmed the overall macrophages and M2 macrophages.
In vitro, exosomes derived from IL-4+IL-13-treated macrophages (M2Es) had been remoted by ultracentrifugation and characterised based mostly on their particular morphology. Ki-67 staining was carried out to evaluate the consequences of the M2Es on the proliferation of RASMCs. An atomic pressure microscope (AFM) was used to detect the stiffness of the VSMCs. GW4869 was used to inhibit exosome launch. RNA-seq was carried out to find out the mRNA profiles of the RASMCs and M2Es-treated RASMCs. Quantitative real-time PCR (qRT-PCR) evaluation was carried out to detect the expression ranges of the mRNAs. Western blotting was used to detect the candidate protein expression ranges. T-5224 was used to inhibit the DNA binding exercise of AP-1 in RASMCs.
Outcomes: M2Es promote c-KIT expression and softening of close by VSMCs, therefore accelerating the vascular tissue restore course of. VSMCs co-cultured in vitro with M2 macrophages introduced an elevated capability for de-differentiation and softening, which was exosome dependent. As well as, the remoted M2Es helped to advertise VSMC dedifferentiation and softening.
Moreover, the M2Es enhanced vascular tissue restore efficiency by upregulation of VSMCs c-KIT expression through activation of the c-Jun/activator protein 1 (AP-1) signaling pathway.
Conclusions: The findings of this examine emphasize the distinguished position of M2Es throughout VSMC dedifferentiation and vascular tissue restore through activation of the c-Jun/AP-1 signaling pathway, which has a profound impression on the therapeutic methods of coronary stenting methods.
ataxin
Leukemia - Hairy Cell Exosome |
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| P141-HC | 101Bio | - | Ask for price |
Leukemia - Multiple Myeloma Exosome |
|||
| P141-MM | 101Bio | - | Ask for price |
Leukemia - Hairy Cell Exosome RNA |
|||
| P241-HC | 101Bio | - | Ask for price |
Leukemia - Multiple Myeloma Exosome RNA |
|||
| P241-MM | 101Bio | - | Ask for price |
Purified Exosomes: HTK562 Human Chronic Myelogenous Leukemia Cell Line |
|||
| EXOP-415A-1 | SBI | 50 µg | EUR 514 |
Bovine Leukemia Virus(Leukemia Virus) |
|||
| QY-E60121 | Qayee Biotechnology | 96T | EUR 511.2 |
Psoriasis Exosome |
|||
| P141-PS | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS) |
|||
| P101NGS | 101Bio | - | Ask for price |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-601-10um | ProSci | 10 um | EUR 241.8 |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-601-4um | ProSci | 4 um | EUR 216.6 |
Lung Cancer Exosome |
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| P141-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome |
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| P141-LV | 101Bio | - | Ask for price |
Acute Myeloid Leukemia 1 Protein (AML1) Antibody |
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| abx430068-200ul | Abbexa | 200 ul | EUR 460.8 |
Acute Myeloid Leukemia 1 Protein (AML1) Antibody |
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| abx010589-100ug | Abbexa | 100 ug | EUR 526.8 |
Breast Cancer Exosome |
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| P141-BR | 101Bio | - | Ask for price |
Crohn's Disease Exosome |
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| P141-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome |
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| P141-KN | 101Bio | - | Ask for price |
Psoriasis Exosome RNA |
|||
| P241-PS | 101Bio | - | Ask for price |
Bladder Cancer Exosome |
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| P141-BL | 101Bio | - | Ask for price |
Thyroid Cancer Exosome |
|||
| P141-TH | 101Bio | - | Ask for price |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-606-10um | ProSci | 10 um | EUR 241.8 |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-606-4um | ProSci | 4 um | EUR 216.6 |
Prostate Cancer Exosome |
|||
| P141-PR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome |
|||
| P141-CO | 101Bio | - | Ask for price |
Lung Cancer Exosome RNA |
|||
| P241-LG | 101Bio | - | Ask for price |
Diabetes (Type 1) Exosome |
|||
| P141-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome |
|||
| P141-DB2 | 101Bio | - | Ask for price |
Normal human exosome RNA |
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| P240 | 101Bio | - | Ask for price |
Liver Cancer Exosome RNA |
|||
| P241-LV | 101Bio | - | Ask for price |
Exosome-TEM-easy Kit |
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| P130 | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome |
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| P141-RA | 101Bio | - | Ask for price |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) |
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| P101EZ | 101Bio | - | Ask for price |
Breast Cancer Exosome RNA |
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| P241-BR | 101Bio | - | Ask for price |
Crohn's Disease Exosome RNA |
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| P241-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome RNA |
|||
| P241-KN | 101Bio | - | Ask for price |
Lyophilized Exosome Standards |
|||
| ExoA375 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoHT29 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoMCF7 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoPC3 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoPLASMA | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoUrine | ImmunoStep | 100 μg | EUR 364.2 |
Nasopharyngeal Cancer Exosome |
|||
| P141-NA | 101Bio | - | Ask for price |
Exosome precipitation Solution |
|||
| EPStep | ImmunoStep | 12 ml | EUR 333 |
Bladder Cancer Exosome RNA |
|||
| P241-BL | 101Bio | - | Ask for price |
Thyroid Cancer Exosome RNA |
|||
| P241-TH | 101Bio | - | Ask for price |
Hairy Cell Leukemia |
|||
| MO47030 | Neuromics | 0.5 ml | EUR 418.8 |
Prostate Cancer Exosome RNA |
|||
| P241-PR | 101Bio | - | Ask for price |
Exosome Component 5 Protein |
|||
| 20-abx260873 | Abbexa |
|
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Exosome Component 7 Protein |
|||
| 20-abx261347 | Abbexa |
|
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Exosome Component 10 Protein |
|||
| 20-abx261805 | Abbexa |
|
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Exosome Component 4 Protein |
|||
| 20-abx261954 | Abbexa |
|
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Exosome Component 9 Protein |
|||
| 20-abx262123 | Abbexa |
|
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Exosome Component 8 Protein |
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| 20-abx262850 | Abbexa |
|
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Exosome Component 3 Protein |
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| 20-abx263422 | Abbexa |
|
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Exosome Component 1 Protein |
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| 20-abx263423 | Abbexa |
|
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Exosome Component 9 Peptide |
|||
| 46-967P | ProSci | 0.1 mg | EUR 405.6 |
|
Description: (CT) PMSCL1 Peptide |
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Melanoma (skin cancer) Exosome |
|||
| P141-MN | 101Bio | - | Ask for price |
Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) |
|||
| P100EZ | 101Bio | - | Ask for price |
Uterine Corpus Cancer Exosome |
|||
| P141-UT | 101Bio | - | Ask for price |
Colorectal Cancer Exosome RNA |
|||
| P241-CO | 101Bio | - | Ask for price |
EXOCET Exosome Quantitation Kit |
|||
| EXOCET96A-1 | SBI | 96 reactions | EUR 462 |
Exo-APC Exosome FACS stain |
|||
| EXOFLOW810A-1 | SBI | 20 reactions | EUR 188 |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample |
|||
| P101EZ--sample | 101Bio | - | Ask for price |
Non-Hodgkin lymphoma Exosome |
|||
| P141-NH | 101Bio | - | Ask for price |
Exo-FITC Exosome FACS stain |
|||
| EXOFLOW800A-1 | SBI | 20 reactions | EUR 188 |
Diabetes (Type 1) Exosome RNA |
|||
| P241-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome RNA |
|||
| P241-DB2 | 101Bio | - | Ask for price |
Uterine Cervical Cancer Exosome |
|||
| P141-UC | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome RNA |
|||
| P241-RA | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome RNA |
|||
| P241-NA | 101Bio | - | Ask for price |
Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample |
|||
| P100EZ-sample | 101Bio | - | Ask for price |
FluoroCet Exosome Quantitation Kit |
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| FCET96A-1 | SBI | 96 reactions | EUR 661 |
Fluorescent Exosome Standard (Urine ) |
|||
| ESF-15 | Creative Biolabs | 100 µg | EUR 2067.6 |
|
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling. |
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Exosome Isolation kit (for urine) |
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| P120L | 101Bio | - | Ask for price |
Exosome Isolation kit (for urine) |
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| P120S | 101Bio | - | Ask for price |
LiqBiopsy Tumor Exosome RNA Kit |
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| K1254-24 | Biovision | each | EUR 1332 |
Exosome Component 3 (EXOSC3) Antibody |
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| 20-abx312069 | Abbexa |
|
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Exosome Component 8 (EXOSC8) Antibody |
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| 20-abx318649 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| abx232898-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx232901-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
|||
| abx232902-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 3 (EXOSC3) Antibody |
|||
| abx232903-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 4 (EXOSC4) Antibody |
|||
| abx232904-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 5 (EXOSC5) Antibody |
|||
| abx232905-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 7 (EXOSC7) Antibody |
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| abx232906-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 8 (EXOSC8) Antibody |
|||
| abx232907-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 9 (EXOSC9) Antibody |
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| abx232908-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx176346 | Abbexa |
|
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx172308 | Abbexa |
|
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx112409 | Abbexa |
|
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx112411 | Abbexa |
|
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Exosome Component 3 (EXOSC3) Antibody |
|||
| 20-abx112412 | Abbexa |
|
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Exosome Component 4 (EXOSC4) Antibody |
|||
| 20-abx112413 | Abbexa |
|
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Exosome Component 5 (EXOSC5) Antibody |
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| 20-abx112414 | Abbexa |
|
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Exosome Component 8 (EXOSC8) Antibody |
|||
| 20-abx112415 | Abbexa |
|
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Exosome Component 1 (EXOSC1) Antibody |
|||
| abx030303-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 1 (EXOSC1) Antibody |
|||
| abx030303-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 8 (EXOSC8) Antibody |
|||
| abx031706-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 8 (EXOSC8) Antibody |
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| abx031706-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx034983-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 2 (EXOSC2) Antibody |
|||
| abx034983-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 4 (EXOSC4) Antibody |
|||
| abx029390-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 4 (EXOSC4) Antibody |
|||
| abx029390-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 7 (EXOSC7) Antibody |
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| 20-abx124556 | Abbexa |
|
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Exosome Component 4 (EXOSC4) Antibody |
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| 20-abx124664 | Abbexa |
|
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx125829 | Abbexa |
|
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx125830 | Abbexa |
|
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Exosome Component 3 (EXOSC3) Antibody |
|||
| 20-abx125831 | Abbexa |
|
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Exosome Component 8 (EXOSC8) Antibody |
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| 20-abx003377 | Abbexa |
|
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx003412 | Abbexa |
|
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx301763 | Abbexa |
|
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Exosome Component 5 (EXOSC5) Antibody |
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| 20-abx302857 | Abbexa |
|
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Melanoma (skin cancer) Exosome RNA |
|||
| P241-MN | 101Bio | - | Ask for price |
Exo-Check Exosome Antibody Array |
|||
| 322-EXO-FBS-50A-1 | Gentaur Genprice | 100 µg | EUR 469.2 |
Exo-Check Exosome Antibody Array |
|||
| EXORAY200A-4 | SBI | 4 arrays | EUR 648 |
Exo-Check Exosome Antibody Array |
|||
| EXORAY200B-4 | SBI | 4 arrays | EUR 480 |
Exo-Check Exosome Antibody Array |
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| EXORAY210A-8 | SBI | 8 arrays | EUR 1176 |
Exo-Check Exosome Antibody Array |
|||
| EXORAY210B-8 | SBI | 8 arrays | EUR 910 |
Exosome Component 10 (EXOSC10) Antibody |
|||
| abx232899-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 10 (EXOSC10) Antibody |
|||
| abx232900-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosomes derived from human amniotic epithelial cells speed up diabetic wound therapeutic through PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast operate
Background: Diabetic wounds are one of the vital widespread and severe problems of diabetes mellitus, characterised by the dysfunction of wound-healing-related cells in amount and high quality. Our earlier research revealed that human amniotic epithelial cells (hAECs) might promote diabetic wound therapeutic by paracrine motion.
Apparently, quite a few research demonstrated that exosomes derived from stem cells are the vital paracrine autos for stem cell remedy. Nonetheless, whether or not exosomes derived from hAECs (hAECs-Exos) mediate the consequences of hAECs on diabetic wound therapeutic stays unclear. This examine aimed to research the organic results of hAECs-Exos on diabetic wound therapeutic and preliminarily elucidate the underlying mechanism.
Strategies: hAECs-Exos had been remoted by ultracentrifugation and recognized by transmission electron microscopy, dynamic mild scattering and circulation cytometry. A collection of in vitro useful analyses had been carried out to evaluate the regulatory results of hAECs-Exos on human fibroblasts (HFBs) and human umbilical vein endothelial cells (HUVECs) in a high-glycemic microenvironment. Excessive-throughput sequencing and bioinformatics analyses had been carried out to invest the associated mechanisms of actions of hAECs-Exos on HFBs and HUVECs. Subsequently, the position of the candidate signaling pathway of hAECs-Exos in regulating the operate of HUVECs and HFBs, in addition to in diabetic wound therapeutic, was assessed.
Outcomes: hAECs-Exos introduced a cup- or sphere-shaped morphology with a imply diameter of 105.89 ± 10.36 nm, had been constructive for CD63 and TSG101 and may very well be internalized by HFBs and HUVECs. After that, hAECs-Exos not solely considerably promoted the proliferation and migration of HFBs, but in addition facilitated the angiogenic exercise of HUVECs in vitro.
Excessive-throughput sequencing revealed enriched miRNAs of hAECs-Exos concerned in wound therapeutic. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have proven that the goal genes of the highest 15 miRNAs had been extremely enriched within the PI3K-AKT pathway. Additional useful research demonstrated that the PI3K-AKT-mTOR pathway was mandatory for the induced organic results of hAECs-Exos on HFBs and HUVECs, in addition to on wound therapeutic, in diabetic mice.
Conclusions: Our findings demonstrated that hAECs-Exos signify a promising, novel technique for diabetic wound therapeutic by selling angiogenesis and fibroblast operate through activation of the PI3K-AKT-mTOR pathway.
Leukemia - Hairy Cell Exosome RNA |
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| P241-HC | 101Bio | - | Ask for price |
Leukemia - Multiple Myeloma Exosome RNA |
|||
| P241-MM | 101Bio | - | Ask for price |
Purified Exosomes: HTK562 Human Chronic Myelogenous Leukemia Cell Line |
|||
| EXOP-415A-1 | SBI | 50 µg | EUR 514 |
K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk) |
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| HCLS-17004 | Alpha Diagnostics | 1 pk | EUR 300 |
Bovine Leukemia Virus(Leukemia Virus) |
|||
| QY-E60121 | Qayee Biotechnology | 96T | EUR 511.2 |
Psoriasis Exosome |
|||
| P141-PS | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS) |
|||
| P101NGS | 101Bio | - | Ask for price |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-601-10um | ProSci | 10 um | EUR 241.8 |
Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-601-4um | ProSci | 4 um | EUR 216.6 |
Lung Cancer Exosome |
|||
| P141-LG | 101Bio | - | Ask for price |
Liver Cancer Exosome |
|||
| P141-LV | 101Bio | - | Ask for price |
Breast Cancer Exosome |
|||
| P141-BR | 101Bio | - | Ask for price |
Crohn's Disease Exosome |
|||
| P141-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome |
|||
| P141-KN | 101Bio | - | Ask for price |
Psoriasis Exosome RNA |
|||
| P241-PS | 101Bio | - | Ask for price |
Bladder Cancer Exosome |
|||
| P141-BL | 101Bio | - | Ask for price |
Thyroid Cancer Exosome |
|||
| P141-TH | 101Bio | - | Ask for price |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-606-10um | ProSci | 10 um | EUR 241.8 |
Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia) |
|||
| 11-606-4um | ProSci | 4 um | EUR 216.6 |
Prostate Cancer Exosome |
|||
| P141-PR | 101Bio | - | Ask for price |
Colorectal Cancer Exosome |
|||
| P141-CO | 101Bio | - | Ask for price |
Lung Cancer Exosome RNA |
|||
| P241-LG | 101Bio | - | Ask for price |
Diabetes (Type 1) Exosome |
|||
| P141-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome |
|||
| P141-DB2 | 101Bio | - | Ask for price |
Normal human exosome RNA |
|||
| P240 | 101Bio | - | Ask for price |
Liver Cancer Exosome RNA |
|||
| P241-LV | 101Bio | - | Ask for price |
Exosome-TEM-easy Kit |
|||
| P130 | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome |
|||
| P141-RA | 101Bio | - | Ask for price |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) |
|||
| P101EZ | 101Bio | - | Ask for price |
Breast Cancer Exosome RNA |
|||
| P241-BR | 101Bio | - | Ask for price |
Crohn's Disease Exosome RNA |
|||
| P241-CR | 101Bio | - | Ask for price |
Kidney Cancer Exosome RNA |
|||
| P241-KN | 101Bio | - | Ask for price |
Lyophilized Exosome Standards |
|||
| ExoA375 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoHT29 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoMCF7 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoPC3 | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoPLASMA | ImmunoStep | 100 μg | EUR 364.2 |
Lyophilized Exosome Standards |
|||
| ExoUrine | ImmunoStep | 100 μg | EUR 364.2 |
Nasopharyngeal Cancer Exosome |
|||
| P141-NA | 101Bio | - | Ask for price |
Exosome precipitation Solution |
|||
| EPStep | ImmunoStep | 12 ml | EUR 333 |
Bladder Cancer Exosome RNA |
|||
| P241-BL | 101Bio | - | Ask for price |
Thyroid Cancer Exosome RNA |
|||
| P241-TH | 101Bio | - | Ask for price |
Hairy Cell Leukemia |
|||
| MO47030 | Neuromics | 0.5 ml | EUR 418.8 |
Prostate Cancer Exosome RNA |
|||
| P241-PR | 101Bio | - | Ask for price |
Exosome Component 5 Protein |
|||
| 20-abx260873 | Abbexa |
|
|
Exosome Component 7 Protein |
|||
| 20-abx261347 | Abbexa |
|
|
Exosome Component 10 Protein |
|||
| 20-abx261805 | Abbexa |
|
|
Exosome Component 4 Protein |
|||
| 20-abx261954 | Abbexa |
|
|
Exosome Component 9 Protein |
|||
| 20-abx262123 | Abbexa |
|
|
Exosome Component 8 Protein |
|||
| 20-abx262850 | Abbexa |
|
|
Exosome Component 3 Protein |
|||
| 20-abx263422 | Abbexa |
|
|
Exosome Component 1 Protein |
|||
| 20-abx263423 | Abbexa |
|
|
Exosome Component 9 Peptide |
|||
| 46-967P | ProSci | 0.1 mg | EUR 405.6 |
|
Description: (CT) PMSCL1 Peptide |
|||
Melanoma (skin cancer) Exosome |
|||
| P141-MN | 101Bio | - | Ask for price |
Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) |
|||
| P100EZ | 101Bio | - | Ask for price |
Uterine Corpus Cancer Exosome |
|||
| P141-UT | 101Bio | - | Ask for price |
Colorectal Cancer Exosome RNA |
|||
| P241-CO | 101Bio | - | Ask for price |
EXOCET Exosome Quantitation Kit |
|||
| EXOCET96A-1 | SBI | 96 reactions | EUR 462 |
Exo-APC Exosome FACS stain |
|||
| EXOFLOW810A-1 | SBI | 20 reactions | EUR 188 |
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample |
|||
| P101EZ--sample | 101Bio | - | Ask for price |
Non-Hodgkin lymphoma Exosome |
|||
| P141-NH | 101Bio | - | Ask for price |
Exo-FITC Exosome FACS stain |
|||
| EXOFLOW800A-1 | SBI | 20 reactions | EUR 188 |
Diabetes (Type 1) Exosome RNA |
|||
| P241-DB1 | 101Bio | - | Ask for price |
Diabetes (Type 2) Exosome RNA |
|||
| P241-DB2 | 101Bio | - | Ask for price |
Uterine Cervical Cancer Exosome |
|||
| P141-UC | 101Bio | - | Ask for price |
Rheumatoid Arthritis Exosome RNA |
|||
| P241-RA | 101Bio | - | Ask for price |
Nasopharyngeal Cancer Exosome RNA |
|||
| P241-NA | 101Bio | - | Ask for price |
Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample |
|||
| P100EZ-sample | 101Bio | - | Ask for price |
FluoroCet Exosome Quantitation Kit |
|||
| FCET96A-1 | SBI | 96 reactions | EUR 661 |
Fluorescent Exosome Standard (Urine ) |
|||
| ESF-15 | Creative Biolabs | 100 µg | EUR 2067.6 |
|
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling. |
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Exosome Isolation kit (for urine) |
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| P120L | 101Bio | - | Ask for price |
Exosome Isolation kit (for urine) |
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| P120S | 101Bio | - | Ask for price |
LiqBiopsy Tumor Exosome RNA Kit |
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| K1254-24 | Biovision | each | EUR 1332 |
Exosome Component 3 (EXOSC3) Antibody |
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| 20-abx312069 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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| 20-abx318649 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| abx232898-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx232901-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx232902-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 3 (EXOSC3) Antibody |
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| abx232903-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 4 (EXOSC4) Antibody |
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| abx232904-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 5 (EXOSC5) Antibody |
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| abx232905-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 7 (EXOSC7) Antibody |
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| abx232906-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 8 (EXOSC8) Antibody |
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| abx232907-100ug | Abbexa | 100 ug | EUR 577.2 |
Exosome Component 9 (EXOSC9) Antibody |
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| abx232908-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx176346 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx172308 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx112409 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx112411 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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| 20-abx112412 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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| 20-abx112413 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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| 20-abx112414 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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| 20-abx112415 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| abx030303-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 1 (EXOSC1) Antibody |
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| abx030303-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 8 (EXOSC8) Antibody |
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| abx031706-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 8 (EXOSC8) Antibody |
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| abx031706-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx034983-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 2 (EXOSC2) Antibody |
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| abx034983-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 4 (EXOSC4) Antibody |
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| abx029390-400ul | Abbexa | 400 ul | EUR 627.6 |
Exosome Component 4 (EXOSC4) Antibody |
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| abx029390-80l | Abbexa | 80 µl | EUR 343.2 |
Exosome Component 7 (EXOSC7) Antibody |
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| 20-abx124556 | Abbexa |
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Exosome Component 4 (EXOSC4) Antibody |
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| 20-abx124664 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx125829 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx125830 | Abbexa |
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Exosome Component 3 (EXOSC3) Antibody |
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| 20-abx125831 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody |
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| 20-abx003377 | Abbexa |
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Exosome Component 2 (EXOSC2) Antibody |
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| 20-abx003412 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody |
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| 20-abx301763 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody |
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| 20-abx302857 | Abbexa |
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Melanoma (skin cancer) Exosome RNA |
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| P241-MN | 101Bio | - | Ask for price |
Exo-Check Exosome Antibody Array |
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| 322-EXO-FBS-50A-1 | Gentaur Genprice | 100 µg | EUR 469.2 |
Exo-Check Exosome Antibody Array |
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| EXORAY200A-4 | SBI | 4 arrays | EUR 648 |
Exo-Check Exosome Antibody Array |
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| EXORAY200B-4 | SBI | 4 arrays | EUR 480 |
Exo-Check Exosome Antibody Array |
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| EXORAY210A-8 | SBI | 8 arrays | EUR 1176 |
Exo-Check Exosome Antibody Array |
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| EXORAY210B-8 | SBI | 8 arrays | EUR 910 |
Exosome Component 10 (EXOSC10) Antibody |
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| abx232899-100ug | Abbexa | 100 ug | EUR 661.2 |
Exosome Component 10 (EXOSC10) Antibody |
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| abx232900-100ug | Abbexa | 100 ug | EUR 610.8 |
Exosome Component 10 (EXOSC10) Antibody |
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| 20-abx112410 | Abbexa |
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Exosome Component 10 (EXOSC10) Antibody |
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| 20-abx334343 | Abbexa |
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Systemic Lupus Erythematosus Exosome |
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| P141-SL | 101Bio | - | Ask for price |
Uterine Corpus Cancer Exosome RNA |
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| P241-UT | 101Bio | - | Ask for price |
Exo-Fect Exosome Transfection Kit |
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| EXFT10A-1 | SBI | 10 reactions | EUR 238 |
Exo-Fect Exosome Transfection Kit |
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| EXFT20A-1 | SBI | 20 reactions | EUR 429 |
Non-Hodgkin lymphoma Exosome RNA |
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| P241-NH | 101Bio | - | Ask for price |
Fetal Bovine Serum（Without Exosome ） |
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| FBSNE-01061 | Cyagen | 20/50mL | Ask for price |
ExoStd? MM1 Fluorescent Exosome Standard |
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| M1078-100 | Biovision | each | EUR 907.2 |
ExoStd? PC3 Fluorescent Exosome Standard |
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| M1086-100 | Biovision | each | EUR 907.2 |
Uterine Cervical Cancer Exosome RNA |
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| P241-UC | 101Bio | - | Ask for price |
ExoStd? A549 Fluorescent Exosome Standard |
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| M1089-100 | Biovision | each | EUR 907.2 |
Mouse Leukemia virus protein |
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| 30-1273 | Fitzgerald | 1 mg | EUR 289.2 |
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Description: Purified native Mouse Leukemia virus protein |
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Hairy Cell Leukemia Antibody |
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| P1056-01m | SAB | 0.1m | EUR 337.2 |
Hairy Cell Leukemia Antibody |
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| P1056-1ml | SAB | 1ml | EUR 1338 |
SeraMir Exosome RNA Ampflication Kit |
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| RA800A-1 | SBI | 20 reactions | EUR 846 |
ExoStd? Serum Fluorescent Exosome Standard |
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| M1074-100 | Biovision | each | EUR 907.2 |
ExoStd? Urine Fluorescent Exosome Standard |
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| M1075-100 | Biovision | each | EUR 907.2 |
ExoStd? COLO1 Fluorescent Exosome Standard |
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| M1077-100 | Biovision | each | EUR 907.2 |
ExoStd? DAUD1 Fluorescent Exosome Standard |
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| M1088-100 | Biovision | each | EUR 907.2 |
LiqBiopsy Tumor Exosome DNA Kit I |
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| K1255-20 | Biovision | each | EUR 1201.2 |
LiqBiopsy Tumor Exosome DNA Kit II |
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| K1256-20 | Biovision | each | EUR 1266 |
ExoStd? Plasma Fluorescent Exosome Standard |
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| M1073-100 | Biovision | each | EUR 907.2 |
ExoStd? Saliva Fluorescent Exosome Standard |
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| M1076-100 | Biovision | each | EUR 907.2 |
ExoStd? BLCL21 Fluorescent Exosome Standard |
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| M1079-100 | Biovision | each | EUR 907.2 |
ExoStd? HCT116 Fluorescent Exosome Standard |
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| M1083-100 | Biovision | each | EUR 907.2 |
ExoStd? B16F10 Fluorescent Exosome Standard |
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| M1159-100 | Biovision | each | EUR 927.6 |
Feline Leukemia virus antibody |
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| 10C-CR1297M1 | Fitzgerald | 100 ug | EUR 296.4 |
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Description: Mouse monoclonal Feline Leukemia virus antibody |
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LIF/Leukemia inhibitory factor |
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| E21-017 | EnoGene | 10ug | EUR 411.6 |
LIF/Leukemia inhibitory factor |
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| E21-690 | EnoGene | 10ug | EUR 411.6 |
Exosome Component 3 (EXOSC3) Antibody (HRP) |
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| 20-abx312070 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody (HRP) |
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| 20-abx312486 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody (HRP) |
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| 20-abx310194 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody (HRP) |
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| 20-abx311411 | Abbexa |
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Recombinant Human Exosome Component 9 |
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| 7-05902 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Exosome Component 9 |
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| 7-05903 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Exosome Component 9 |
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| 7-05904 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Exosome Component 10 |
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| 7-05905 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Exosome Component 10 |
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| 7-05906 | CHI Scientific | 20µg | Ask for price |
Recombinant Human Exosome Component 10 |
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| 7-05907 | CHI Scientific | 1mg | Ask for price |
B-Cell Leukemia/Lymphoma 2 |
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| PR27249 | Neuromics | 5 ug | EUR 229.2 |
Feline leukemia virus PCR kit |
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| PCR-V176-48R | Bioingentech | 50T | EUR 987.6 |
Feline leukemia virus PCR kit |
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| PCR-V176-96R | Bioingentech | 100T | EUR 1335.6 |
Bovine leukemia virus PCR kit |
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| PCR-V221-48R | Bioingentech | 50T | EUR 987.6 |
Bovine leukemia virus PCR kit |
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| PCR-V221-96R | Bioingentech | 100T | EUR 1335.6 |
Exosome Component 3 (EXOSC3) Antibody (FITC) |
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| 20-abx312071 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody (FITC) |
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| 20-abx312487 | Abbexa |
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Exosome Component 10 (EXOSC10) Antibody (HRP) |
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| 20-abx335640 | Abbexa |
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Human Exosome Component 2 (EXOSC2) Protein |
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| 20-abx653328 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody (FITC) |
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| 20-abx310195 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody (FITC) |
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| 20-abx311412 | Abbexa |
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Exosome-depleted FBS Media Supplement |
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| EXO-FBS-250A-1 | SBI | 250 ml | EUR 837 |
Exosome-depleted FBS Media Supplement |
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| EXO-FBS-50A-1 | SBI | 50 ml | EUR 193 |
Human Leukemia Inhibitory Factor |
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| 90208-A | BPS Bioscience | 2 µg | EUR 130 |
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Description: LIF is a disulfide-linked monomer protein consisting of 181 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducingand reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human LIF mature chain was expressed in E. coli. |
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Human Leukemia Inhibitory Factor |
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| 90208-B | BPS Bioscience | 10 µg | EUR 205 |
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Description: LIF is a disulfide-linked monomer protein consisting of 181 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducingand reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human LIF mature chain was expressed in E. coli. |
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Mouse Leukemia Inhibitory Factor |
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| 90209-A | BPS Bioscience | 2 µg | EUR 130 |
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Description: LIF is a disulfide-linked monomer protein consisting of 181 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducingand reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine LIF mature chain was expressed in E. coli. |
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Mouse Leukemia Inhibitory Factor |
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| 90209-B | BPS Bioscience | 10 µg | EUR 205 |
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Description: LIF is a disulfide-linked monomer protein consisting of 181 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducingand reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine LIF mature chain was expressed in E. coli. |
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Cat Leukemia Virus p27 Protein |
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| 20-abx260224 | Abbexa |
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Exosome Component 10 (EXOSC10) Antibody (FITC) |
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| 20-abx335641 | Abbexa |
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ExoStd? U87 MG Fluorescent Exosome Standard |
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| M1084-100 | Biovision | each | EUR 907.2 |
Lyophilized Exosome Standard (Human Urine) |
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| ESL-29 | Creative Biolabs | 30 µgx2 vials | EUR 1620 |
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Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples. |
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Lyophilized Exosome Standard (Human Serum) |
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| ESL-32 | Creative Biolabs | 30 µgx2 vials | EUR 1620 |
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Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples. |
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Systemic Lupus Erythematosus Exosome RNA |
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| P241-SL | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma) |
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| P101 | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma) |
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| P101L | 101Bio | - | Ask for price |
Exosome Isolation kit (for serum & plasma) |
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| P101S | 101Bio | - | Ask for price |
Exosome Component 3 (EXOSC3) Antibody (Biotin) |
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| 20-abx312072 | Abbexa |
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Exosome Component 1 (EXOSC1) Antibody (Biotin) |
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| 20-abx312488 | Abbexa |
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Exosome Component 8 (EXOSC8) Antibody (Biotin) |
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| 20-abx310196 | Abbexa |
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Exosome Component 5 (EXOSC5) Antibody (Biotin) |
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| 20-abx311413 | Abbexa |
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ExoStd? BPH-1 Fluorescent Exosome Standard |
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| M1087-100 | Biovision | each | EUR 907.2 |
ExoStd? K-562 Fluorescent Exosome Standard |
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| M1154-100 | Biovision | each | EUR 927.6 |
ExoDNAPS? Conc Exosome DNA Extraction Kit |
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| K1243-20 | Biovision | each | EUR 992.4 |