Human Amniotic epithelial cells accelerate diabetic wound healing

M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular easy muscle cells throughout vascular tissue restore after intravascular stent implantation

Rationale: For intravascular stent implantation to achieve success, the processes of vascular tissue restore and remedy are thought-about to be vital. Nonetheless, the mechanisms underlying the eventual destiny of vascular easy muscle cells (VSMCs) throughout vascular tissue restore stays elusive. On this examine, we hypothesized that M2 macrophage-derived exosomes to mediate cell-to-cell crosstalk and induce dedifferentiation phenotypes in VSMCs.

Strategies: In vivo, 316L naked steel stents (BMS) had been implanted from the left iliac artery into the belly aorta of 12-week-old male Sprague-Dawley (SD) rats for 7 and 28 days. Hematoxylin and eosin (HE) had been used to stain the neointimal lesions. En-face immunofluorescence staining of easy muscle 22 alpha (SM22α) and CD68 confirmed the rat aorta easy muscle cells (RASMCs) and macrophages. Immunohistochemical staining of complete galactose-specific lectin 3 (MAC-2) and complete chitinase 3-like 3 (YM-1) confirmed the overall macrophages and M2 macrophages.

In vitro, exosomes derived from IL-4+IL-13-treated macrophages (M2Es) had been remoted by ultracentrifugation and characterised based mostly on their particular morphology. Ki-67 staining was carried out to evaluate the consequences of the M2Es on the proliferation of RASMCs. An atomic pressure microscope (AFM) was used to detect the stiffness of the VSMCs. GW4869 was used to inhibit exosome launch. RNA-seq was carried out to find out the mRNA profiles of the RASMCs and M2Es-treated RASMCs. Quantitative real-time PCR (qRT-PCR) evaluation was carried out to detect the expression ranges of the mRNAs. Western blotting was used to detect the candidate protein expression ranges. T-5224 was used to inhibit the DNA binding exercise of AP-1 in RASMCs.

Outcomes: M2Es promote c-KIT expression and softening of close by VSMCs, therefore accelerating the vascular tissue restore course of. VSMCs co-cultured in vitro with M2 macrophages introduced an elevated capability for de-differentiation and softening, which was exosome dependent. As well as, the remoted M2Es helped to advertise VSMC dedifferentiation and softening.

Moreover, the M2Es enhanced vascular tissue restore efficiency by upregulation of VSMCs c-KIT expression through activation of the c-Jun/activator protein 1 (AP-1) signaling pathway.

Conclusions: The findings of this examine emphasize the distinguished position of M2Es throughout VSMC dedifferentiation and vascular tissue restore through activation of the c-Jun/AP-1 signaling pathway, which has a profound impression on the therapeutic methods of coronary stenting methods.

Leukemia - CLL Exosome RNA
P241-CLL	101Bio	-	Ask for price

Leukemia - CML Exosome RNA
P241-CML	101Bio	-	Ask for price

Leukemia - Hairy Cell Exosome RNA
P241-HC	101Bio	-	Ask for price

Leukemia - Multiple Myeloma Exosome RNA
P241-MM	101Bio	-	Ask for price

pReceiver-Lv105-AML-1B Plasmid
PVTB00282S	Lifescience Market	2 ug	EUR 356

Aqueous Mount (Low Viscosity)
AML-10000	ScyTek Laboratories	10 L	EUR 2083

Psoriasis Exosome
P141-PS	101Bio	-	Ask for price

Bladder Cancer Exosome
P141-BL	101Bio	-	Ask for price

Breast Cancer Exosome
P141-BR	101Bio	-	Ask for price

Colorectal Cancer Exosome
P141-CO	101Bio	-	Ask for price

Crohn's Disease Exosome
P141-CR	101Bio	-	Ask for price

Kidney Cancer Exosome
P141-KN	101Bio	-	Ask for price

Lung Cancer Exosome
P141-LG	101Bio	-	Ask for price

Liver Cancer Exosome
P141-LV	101Bio	-	Ask for price

Nasopharyngeal Cancer Exosome
P141-NA	101Bio	-	Ask for price

Prostate Cancer Exosome
P141-PR	101Bio	-	Ask for price

Rheumatoid Arthritis Exosome
P141-RA	101Bio	-	Ask for price

Thyroid Cancer Exosome
P141-TH	101Bio	-	Ask for price

Psoriasis Exosome RNA
P241-PS	101Bio	-	Ask for price

Lyophilized Exosome Standards
ExoA375	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoHT29	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoMCF7	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoPC3	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoPLASMA	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoUrine	ImmunoStep	100 μg	EUR 303.5

Exosome precipitation Solution
EPStep	ImmunoStep	12 ml	EUR 277.5

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)
P101NGS	101Bio	-	Ask for price

Bovine Leukemia Virus(Leukemia Virus)
QY-E60121	Qayee Biotechnology	96T	EUR 426

Fluorescent Exosome Standard (Urine )
ESF-15	Creative Biolabs	100 µg	EUR 1723
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

Exosome-TEM-easy Kit
P130	101Bio	-	Ask for price

Normal human exosome sample
P140	101Bio	-	Ask for price

Diabetes (Type 1) Exosome
P141-DB1	101Bio	-	Ask for price

Diabetes (Type 2) Exosome
P141-DB2	101Bio	-	Ask for price

Melanoma (skin cancer) Exosome
P141-MN	101Bio	-	Ask for price

Non-Hodgkin lymphoma Exosome
P141-NH	101Bio	-	Ask for price

Systemic Lupus Erythematosus Exosome
P141-SL	101Bio	-	Ask for price

Uterine Cervical Cancer Exosome
P141-UC	101Bio	-	Ask for price

Uterine Corpus Cancer Exosome
P141-UT	101Bio	-	Ask for price

Normal human exosome RNA
P240	101Bio	-	Ask for price

Bladder Cancer Exosome RNA
P241-BL	101Bio	-	Ask for price

Breast Cancer Exosome RNA
P241-BR	101Bio	-	Ask for price

Colorectal Cancer Exosome RNA
P241-CO	101Bio	-	Ask for price

Crohn's Disease Exosome RNA
P241-CR	101Bio	-	Ask for price

Kidney Cancer Exosome RNA
P241-KN	101Bio	-	Ask for price

Lung Cancer Exosome RNA
P241-LG	101Bio	-	Ask for price

Liver Cancer Exosome RNA
P241-LV	101Bio	-	Ask for price

Nasopharyngeal Cancer Exosome RNA
P241-NA	101Bio	-	Ask for price

Prostate Cancer Exosome RNA
P241-PR	101Bio	-	Ask for price

Rheumatoid Arthritis Exosome RNA
P241-RA	101Bio	-	Ask for price

Thyroid Cancer Exosome RNA
P241-TH	101Bio	-	Ask for price

Exosome Component 5 Protein
20-abx260873	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

Exosome Component 7 Protein
20-abx261347	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 10 Protein
20-abx261805	Abbexa	EUR 4365.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 4 Protein
20-abx261954	Abbexa	EUR 4490.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 9 Protein
20-abx262123	Abbexa	EUR 328.00 EUR 5089.00 EUR 230.00	10 ug 1 mg 2 µg

Exosome Component 8 Protein
20-abx262850	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Exosome Component 3 Protein
20-abx263422	Abbexa	EUR 230.00 EUR 1609.00 EUR 328.00	1 µg 50 ug 5 ug

Exosome Component 1 Protein
20-abx263423	Abbexa	EUR 1609.00 EUR 328.00 EUR 230.00	100 ug 10 ug 2 µg

EXOCET Exosome Quantitation Kit
EXOCET96A-1	SBI	96 reactions	EUR 521

FluoroCet Exosome Quantitation Kit
FCET96A-1	SBI	96 reactions	EUR 726

Exosome Component 9 Peptide
46-967P	ProSci	0.1 mg	EUR 338
Description: (CT) PMSCL1 Peptide

Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-601-10um	ProSci	10 um	EUR 201.5

Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-601-4um	ProSci	4 um	EUR 180.5

ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome)
P402	101Bio	-	Ask for price

Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-606-10um	ProSci	10 um	EUR 201.5

Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-606-4um	ProSci	4 um	EUR 180.5

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)
P101EZ	101Bio	-	Ask for price

Lyophilized Exosome Standard (Human Plasma)
ESL-25	Creative Biolabs	30 µgx2 vials	EUR 1337
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Saliva)
ESL-27	Creative Biolabs	30 µgx6 vials	EUR 3023
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Urine)
ESL-29	Creative Biolabs	30 µgx2 vials	EUR 1350
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Serum)
ESL-32	Creative Biolabs	30 µgx2 vials	EUR 1350
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Exosome Isolation kit (for urine)
P120	101Bio	-	Ask for price

Exosome Isolation kit (for urine)
P120L	101Bio	-	Ask for price

Exosome Isolation kit (for urine)
P120S	101Bio	-	Ask for price

Diabetes (Type 1) Exosome RNA
P241-DB1	101Bio	-	Ask for price

Diabetes (Type 2) Exosome RNA
P241-DB2	101Bio	-	Ask for price

Melanoma (skin cancer) Exosome RNA
P241-MN	101Bio	-	Ask for price

Non-Hodgkin lymphoma Exosome RNA
P241-NH	101Bio	-	Ask for price

Systemic Lupus Erythematosus Exosome RNA
P241-SL	101Bio	-	Ask for price

Uterine Cervical Cancer Exosome RNA
P241-UC	101Bio	-	Ask for price

Uterine Corpus Cancer Exosome RNA
P241-UT	101Bio	-	Ask for price

sRNA-into-Exosome Kit (Electro)
P400	101Bio	-	Ask for price

sRNA-into-Exosome Kit (Chemical)
P401	101Bio	-	Ask for price

Exosome Component 1 (EXOSC1) Antibody
20-abx125829	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx125830	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 3 (EXOSC3) Antibody
20-abx125831	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 1 (EXOSC1) Antibody
20-abx112409	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 10 (EXOSC10) Antibody
20-abx112410	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx112411	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 3 (EXOSC3) Antibody
20-abx112412	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 4 (EXOSC4) Antibody
20-abx112413	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 5 (EXOSC5) Antibody
20-abx112414	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 8 (EXOSC8) Antibody
20-abx112415	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 7 (EXOSC7) Antibody
20-abx124556	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 4 (EXOSC4) Antibody
20-abx124664	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 8 (EXOSC8) Antibody
20-abx318649	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 3 (EXOSC3) Antibody
20-abx312069	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 8 (EXOSC8) Antibody
20-abx003377	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx003412	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Exosome Component 2 (EXOSC2) Antibody
abx034983-400ul	Abbexa	400 ul	EUR 523

Exosome Component 2 (EXOSC2) Antibody
abx034983-80l	Abbexa	80 µl	EUR 286

Recombinant Human Exosome Component 9
7-05902	CHI Scientific	2µg	Ask for price

Recombinant Human Exosome Component 9
7-05903	CHI Scientific	10µg	Ask for price

Recombinant Human Exosome Component 9
7-05904	CHI Scientific	1mg	Ask for price

Recombinant Human Exosome Component 10
7-05905	CHI Scientific	5µg	Ask for price

Recombinant Human Exosome Component 10
7-05906	CHI Scientific	20µg	Ask for price

Recombinant Human Exosome Component 10
7-05907	CHI Scientific	1mg	Ask for price

Exosome Component 8 (EXOSC8) Antibody
abx031706-400ul	Abbexa	400 ul	EUR 523

Exosome Component 8 (EXOSC8) Antibody
abx031706-80l	Abbexa	80 µl	EUR 286

Exosome Component 4 (EXOSC4) Antibody
abx029390-400ul	Abbexa	400 ul	EUR 523

Exosome Component 4 (EXOSC4) Antibody
abx029390-80l	Abbexa	80 µl	EUR 286

Exosome Component 1 (EXOSC1) Antibody
abx030303-400ul	Abbexa	400 ul	EUR 523

Exosome Component 1 (EXOSC1) Antibody
abx030303-80l	Abbexa	80 µl	EUR 286

Exosome Component 1 (EXOSC1) Antibody
abx232898-100ug	Abbexa	100 ug	EUR 481

Exosome Component 10 (EXOSC10) Antibody
abx232899-100ug	Abbexa	100 ug	EUR 551

Exosome Component 10 (EXOSC10) Antibody
abx232900-100ug	Abbexa	100 ug	EUR 509

Exosome Component 2 (EXOSC2) Antibody
abx232901-100ug	Abbexa	100 ug	EUR 481

Exosome Component 2 (EXOSC2) Antibody
abx232902-100ug	Abbexa	100 ug	EUR 551

Exosome Component 3 (EXOSC3) Antibody
abx232903-100ug	Abbexa	100 ug	EUR 481

Exosome Component 4 (EXOSC4) Antibody
abx232904-100ug	Abbexa	100 ug	EUR 481

 

Exosomes derived from human amniotic epithelial cells speed up diabetic wound therapeutic through PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast operate

Background: Diabetic wounds are one of the vital widespread and severe problems of diabetes mellitus, characterised by the dysfunction of wound-healing-related cells in amount and high quality. Our earlier research revealed that human amniotic epithelial cells (hAECs) might promote diabetic wound therapeutic by paracrine motion.

 

Apparently, quite a few research demonstrated that exosomes derived from stem cells are the vital paracrine autos for stem cell remedy. Nonetheless, whether or not exosomes derived from hAECs (hAECs-Exos) mediate the consequences of hAECs on diabetic wound therapeutic stays unclear. This examine aimed to research the organic results of hAECs-Exos on diabetic wound therapeutic and preliminarily elucidate the underlying mechanism.

 

Strategies: hAECs-Exos had been remoted by ultracentrifugation and recognized by transmission electron microscopy, dynamic mild scattering and circulation cytometry. A collection of in vitro useful analyses had been carried out to evaluate the regulatory results of hAECs-Exos on human fibroblasts (HFBs) and human umbilical vein endothelial cells (HUVECs) in a high-glycemic microenvironment. Excessive-throughput sequencing and bioinformatics analyses had been carried out to invest the associated mechanisms of actions of hAECs-Exos on HFBs and HUVECs. Subsequently, the position of the candidate signaling pathway of hAECs-Exos in regulating the operate of HUVECs and HFBs, in addition to in diabetic wound therapeutic, was assessed.

 

Outcomes: hAECs-Exos introduced a cup- or sphere-shaped morphology with a imply diameter of 105.89 ± 10.36 nm, had been constructive for CD63 and TSG101 and may very well be internalized by HFBs and HUVECs. After that, hAECs-Exos not solely considerably promoted the proliferation and migration of HFBs, but in addition facilitated the angiogenic exercise of HUVECs in vitro.

 

Excessive-throughput sequencing revealed enriched miRNAs of hAECs-Exos concerned in wound therapeutic. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have proven that the goal genes of the highest 15 miRNAs had been extremely enriched within the PI3K-AKT pathway. Additional useful research demonstrated that the PI3K-AKT-mTOR pathway was mandatory for the induced organic results of hAECs-Exos on HFBs and HUVECs, in addition to on wound therapeutic, in diabetic mice.

 

Conclusions: Our findings demonstrated that hAECs-Exos signify a promising, novel technique for diabetic wound therapeutic by selling angiogenesis and fibroblast operate through activation of the PI3K-AKT-mTOR pathway.

 

General Carboxymethyl Lysine (CML) ELISA Kit
RDR-CML-Ge-96Tests	Reddot Biotech	96 Tests	EUR 854

Leukemia - Hairy Cell Exosome
P141-HC	101Bio	-	Ask for price

Leukemia - Multiple Myeloma Exosome
P141-MM	101Bio	-	Ask for price

Leukemia - ALL Exosome RNA
P241-ALL	101Bio	-	Ask for price

Leukemia - AML Exosome RNA
P241-AML	101Bio	-	Ask for price

Leukemia - CLL Exosome RNA
P241-CLL	101Bio	-	Ask for price

Leukemia - Hairy Cell Exosome RNA
P241-HC	101Bio	-	Ask for price

Leukemia - Multiple Myeloma Exosome RNA
P241-MM	101Bio	-	Ask for price

CML-BSA Control
STA-314	Cell Biolabs	100 µg	EUR 322
Description: CML-BSA may be used as a positive control. 100 µg. Provided at 1 mg/mL in 1X PBS

Sheep CML ELISA Kit
ESC0780	Abclonal	96Tests	EUR 521

Anserini CML ELISA Kit
EAC0780	Abclonal	96Tests	EUR 521

Rat CML ELISA Kit
ERC0780	Abclonal	96Tests	EUR 521

Rabbit CML ELISA Kit
ERTC0780	Abclonal	96Tests	EUR 521

Mouse CML ELISA Kit
EMC0780	Abclonal	96Tests	EUR 521

Monkey CML ELISA Kit
EMKC0780	Abclonal	96Tests	EUR 521

Porcine CML ELISA Kit
EPC0780	Abclonal	96Tests	EUR 521

Human CML ELISA Kit
EHC0780	Abclonal	96Tests	EUR 521

Canine CML ELISA Kit
ECC0780	Abclonal	96Tests	EUR 521

Chicken CML ELISA Kit
ECKC0780	Abclonal	96Tests	EUR 521

Goat CML ELISA Kit
EGTC0780	Abclonal	96Tests	EUR 521

Bovine CML ELISA Kit
EBC0780	Abclonal	96Tests	EUR 521

Carboxymethyl Lysine (CML) Antibody
abx023261-1mg	Abbexa	1 mg	EUR 1080

CML ELISA KIT|Human
EF007324	Lifescience Market	96 Tests	EUR 689

Psoriasis Exosome
P141-PS	101Bio	-	Ask for price

Guinea Pig CML ELISA Kit
EGC0780	Abclonal	96Tests	EUR 521

Carboxymethyl Lysine (CML) ELISA Kit
20-abx150327	Abbexa	EUR 7645.00 EUR 4074.00 EUR 942.00	10 × 96 tests 5 × 96 tests 96 tests

Carboxymethyl Lysine (CML) CLIA Kit
20-abx490445	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Carboxymethyl Lysine (CML) ELISA Kit
E4634-100	Biovision		EUR 729

K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk)
HCLS-17004	Alpha Diagnostics	1 pk	EUR 250

Bladder Cancer Exosome
P141-BL	101Bio	-	Ask for price

Breast Cancer Exosome
P141-BR	101Bio	-	Ask for price

Colorectal Cancer Exosome
P141-CO	101Bio	-	Ask for price

Crohn's Disease Exosome
P141-CR	101Bio	-	Ask for price

Kidney Cancer Exosome
P141-KN	101Bio	-	Ask for price

Lung Cancer Exosome
P141-LG	101Bio	-	Ask for price

Liver Cancer Exosome
P141-LV	101Bio	-	Ask for price

Nasopharyngeal Cancer Exosome
P141-NA	101Bio	-	Ask for price

Prostate Cancer Exosome
P141-PR	101Bio	-	Ask for price

Rheumatoid Arthritis Exosome
P141-RA	101Bio	-	Ask for price

Thyroid Cancer Exosome
P141-TH	101Bio	-	Ask for price

Psoriasis Exosome RNA
P241-PS	101Bio	-	Ask for price

Lyophilized Exosome Standards
ExoA375	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoHT29	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoMCF7	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoPC3	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoPLASMA	ImmunoStep	100 μg	EUR 303.5

Lyophilized Exosome Standards
ExoUrine	ImmunoStep	100 μg	EUR 303.5

Exosome precipitation Solution
EPStep	ImmunoStep	12 ml	EUR 277.5

Human Carboxymethyl lysine, CML ELISA Kit
CSB-E12798h-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Carboxymethyl lysine, CML in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Carboxymethyl lysine, CML ELISA Kit
1-CSB-E12798h	Cusabio	EUR 900.00 EUR 5476.00 EUR 2900.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Carboxymethyl lysine, CML in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

General Carboxymethyl Lysine (CML) ELISA Kit
CEB977Ge-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5438.36
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids.

General Carboxymethyl Lysine (CML) ELISA Kit
CEB977Ge-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 535.51
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids.

General Carboxymethyl Lysine (CML) ELISA Kit
CEB977Ge-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 722.16
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids.

General Carboxymethyl Lysine (CML) ELISA Kit
CEB977Ge-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2949.72
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of General Carboxymethyl Lysine (CML) in serum, plasma and other biological fluids.

General Carboxymethyl Lysine (CML) ELISA Kit
4-CEB977Ge	Cloud-Clone	EUR 5489.00 EUR 2900.00 EUR 723.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of General Carboxymethyl Lysine (CML) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Carboxymethyl lysine(CML)ELISA Kit
GA-E1430HM-48T	GenAsia Biotech	48T	EUR 289

Human Carboxymethyl lysine(CML)ELISA Kit
GA-E1430HM-96T	GenAsia Biotech	96T	EUR 466

Human Carboxymethyl lysine,CML ELISA Kit
201-12-1414	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

N(6)-Carboxymethyllysine (CML) ELISA Kit
abx575945-96tests	Abbexa	96 tests	EUR 668

General Carboxymethyl Lysine ELISA Kit (CML)
RK00635	Abclonal	96 Tests	EUR 521

Human Carboxymethyl lysine(CML)ELISA Kit
QY-E01351	Qayee Biotechnology	96T	EUR 361

Human CML(Carboxymethyl Lysine) ELISA Kit
EH4116	FN Test	96T	EUR 524.1
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.4 ng/ml

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)
P101NGS	101Bio	-	Ask for price

Bovine Leukemia Virus(Leukemia Virus)
QY-E60121	Qayee Biotechnology	96T	EUR 426

ELISA kit for General CML (Carboxymethyl Lysine)
ELK7896	ELK Biotech	1 plate of 96 wells	EUR 372
Description: A competitive Inhibition ELISA kit for detection of Carboxymethyl Lysine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

General CML/ N(6)-Carboxymethyllysine ELISA Kit
E0014Ge	Sunlong	1 Kit	EUR 717

Goat Anti-N-epsilon-CML Polyclonal Antibody
STA-013	Cell Biolabs	100 µg	EUR 508
Description: Goat Anti-CML Polyclonal Antibody is Affinity purified and suitable for Western blot or ELISA. Suitable for use with any species. 100 µg.

Rabbit Anti-N-epsilon-CML Polyclonal Antibody
STA-014	Cell Biolabs	100 µg	EUR 508
Description: Rabbit Anti-CML Polyclonal Antibody is Affinity purified and suitable for Western blot or ELISA. Suitable for use with any species. 100 µg.

General N(6)- Carboxymethyllysine, CML ELISA KIT
ELI-06348Ge	Lifescience Market	96 Tests	EUR 886

Bovine N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019b	Lifescience Market	96 Tests	EUR 928

Chicken N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019c	Lifescience Market	96 Tests	EUR 928

Canine N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019d	Lifescience Market	96 Tests	EUR 928

General N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019Ge	Lifescience Market	96 Tests	EUR 886

Human N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019h	Lifescience Market	96 Tests	EUR 824

Mouse N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019m	Lifescience Market	96 Tests	EUR 865

Porcine N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019p	Lifescience Market	96 Tests	EUR 928

Rat N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019r	Lifescience Market	96 Tests	EUR 886

Rabbit N(6)- Carboxymethyllysine, CML ELISA Kit
CELI-66019Rb	Lifescience Market	96 Tests	EUR 928

Fluorescent Exosome Standard (Urine )
ESF-15	Creative Biolabs	100 µg	EUR 1723
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

Exosome-TEM-easy Kit
P130	101Bio	-	Ask for price

Normal human exosome sample
P140	101Bio	-	Ask for price

Diabetes (Type 1) Exosome
P141-DB1	101Bio	-	Ask for price

Diabetes (Type 2) Exosome
P141-DB2	101Bio	-	Ask for price

Melanoma (skin cancer) Exosome
P141-MN	101Bio	-	Ask for price

Non-Hodgkin lymphoma Exosome
P141-NH	101Bio	-	Ask for price

Systemic Lupus Erythematosus Exosome
P141-SL	101Bio	-	Ask for price

Uterine Cervical Cancer Exosome
P141-UC	101Bio	-	Ask for price

Uterine Corpus Cancer Exosome
P141-UT	101Bio	-	Ask for price

Normal human exosome RNA
P240	101Bio	-	Ask for price

Bladder Cancer Exosome RNA
P241-BL	101Bio	-	Ask for price

Breast Cancer Exosome RNA
P241-BR	101Bio	-	Ask for price

Colorectal Cancer Exosome RNA
P241-CO	101Bio	-	Ask for price

Crohn's Disease Exosome RNA
P241-CR	101Bio	-	Ask for price

Kidney Cancer Exosome RNA
P241-KN	101Bio	-	Ask for price

Lung Cancer Exosome RNA
P241-LG	101Bio	-	Ask for price

Liver Cancer Exosome RNA
P241-LV	101Bio	-	Ask for price

Nasopharyngeal Cancer Exosome RNA
P241-NA	101Bio	-	Ask for price

Prostate Cancer Exosome RNA
P241-PR	101Bio	-	Ask for price

Rheumatoid Arthritis Exosome RNA
P241-RA	101Bio	-	Ask for price

Thyroid Cancer Exosome RNA
P241-TH	101Bio	-	Ask for price

Exosome Component 5 Protein
20-abx260873	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

Exosome Component 7 Protein
20-abx261347	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 10 Protein
20-abx261805	Abbexa	EUR 4365.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 4 Protein
20-abx261954	Abbexa	EUR 4490.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug

Exosome Component 9 Protein
20-abx262123	Abbexa	EUR 328.00 EUR 5089.00 EUR 230.00	10 ug 1 mg 2 µg

Exosome Component 8 Protein
20-abx262850	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Exosome Component 3 Protein
20-abx263422	Abbexa	EUR 230.00 EUR 1609.00 EUR 328.00	1 µg 50 ug 5 ug

Exosome Component 1 Protein
20-abx263423	Abbexa	EUR 1609.00 EUR 328.00 EUR 230.00	100 ug 10 ug 2 µg

EXOCET Exosome Quantitation Kit
EXOCET96A-1	SBI	96 reactions	EUR 521

FluoroCet Exosome Quantitation Kit
FCET96A-1	SBI	96 reactions	EUR 726

Exosome Component 9 Peptide
46-967P	ProSci	0.1 mg	EUR 338
Description: (CT) PMSCL1 Peptide

Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-601-10um	ProSci	10 um	EUR 201.5

Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-601-4um	ProSci	4 um	EUR 180.5

ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome)
P402	101Bio	-	Ask for price

Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-606-10um	ProSci	10 um	EUR 201.5

Lymphoma/Leukemia-Spleen Tissue Slide (Lymphoma/Leukemia)
11-606-4um	ProSci	4 um	EUR 180.5

ELISA kit for Rat N(6)-Carboxymethyllysine (CML)
KTE101082-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2252
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat N(6)-Carboxymethyllysine (CML)
KTE101082-48T	Abbkine	48T	EUR 354
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat N(6)-Carboxymethyllysine (CML)
KTE101082-96T	Abbkine	96T	EUR 572
Description: Quantitative sandwich ELISA for measuring Rat N(6)-Carboxymethyllysine (CML) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

OxiSelect N-epsilon-(Carboxymethyl) Lysine (CML) Immunoblot Kit
STA-313	Cell Biolabs	10 blots	EUR 531
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Immunoblot kit specifically detects CML formation in protein samples.

OxiSelect N?-(carboxymethyl) lysine (CML) Competitive ELISA Kit
STA-816	Cell Biolabs	96 assays	EUR 798
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Competitive ELISA kit specifically detects CML formation with a high level of sensitivity. This is a Competitive ELISA Kit in which the plate is coated with a CML conjugate.  Standards and unknown samples are added to the plate, followed by incubation with the primary antibody. The CML in the unknown samples and the CML attached to the plate compete for the primary antibody. Higher CML content in unknown samples results in more binding of the antibody to the sample, and thus less antibody binds to the plate. Since the antibody bound to the sample is washed away, higher CML content in samples correlates with a lower signal.

OxiSelect N?-(carboxymethyl) lysine (CML) Competitive ELISA Kit
STA-816-5	Cell Biolabs	5 x 96 assays	EUR 3240
Description: Advanced glycation end products (AGE) are formed during the Maillard reaction where reducing carbohydrates react with lysine side chains and N-terminal amino groups of various macromolecules, particularly proteins. The advanced glycation end products can adversely affect the fuction of these macromolecules. One of the most prevalent AGE products, N-epsilon-(Carboxymethyl) Lysine, has been implicated in oxidative stress and vascular damage. The OxiSelect N-epsilon-(Carboxymethyl) Lysine Competitive ELISA kit specifically detects CML formation with a high level of sensitivity. This is a Competitive ELISA Kit in which the plate is coated with a CML conjugate.  Standards and unknown samples are added to the plate, followed by incubation with the primary antibody. The CML in the unknown samples and the CML attached to the plate compete for the primary antibody. Higher CML content in unknown samples results in more binding of the antibody to the sample, and thus less antibody binds to the plate. Since the antibody bound to the sample is washed away, higher CML content in samples correlates with a lower signal.

Anti CML Monoclonal Antibody (Clone No. CMS-10)
KH011	Sceti		EUR 714
Description: The Anti CML Monoclonal Antibody (Clone No. CMS-10) is available in Europe and for worldwide shipping via Gentaur.

Anti CML Monoclonal Antibody (Clone No. NF-1G)
KH024	Sceti		EUR 714
Description: The Anti CML Monoclonal Antibody (Clone No. NF-1G) is available in Europe and for worldwide shipping via Gentaur.

CML ELISA Kit| Rat Carboxymethyl Lysine ELISA Kit
EF018173	Lifescience Market	96 Tests	EUR 689

CML ELISA Kit| Mouse Carboxymethyl Lysine ELISA Kit
EF014018	Lifescience Market	96 Tests	EUR 689

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)
P101EZ	101Bio	-	Ask for price

Lyophilized Exosome Standard (Human Plasma)
ESL-25	Creative Biolabs	30 µgx2 vials	EUR 1337
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Saliva)
ESL-27	Creative Biolabs	30 µgx6 vials	EUR 3023
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Urine)
ESL-29	Creative Biolabs	30 µgx2 vials	EUR 1350
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Lyophilized Exosome Standard (Human Serum)
ESL-32	Creative Biolabs	30 µgx2 vials	EUR 1350
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Exosome Isolation kit (for urine)
P120	101Bio	-	Ask for price

Exosome Isolation kit (for urine)
P120L	101Bio	-	Ask for price

Exosome Isolation kit (for urine)
P120S	101Bio	-	Ask for price

Diabetes (Type 1) Exosome RNA
P241-DB1	101Bio	-	Ask for price

Diabetes (Type 2) Exosome RNA
P241-DB2	101Bio	-	Ask for price

Melanoma (skin cancer) Exosome RNA
P241-MN	101Bio	-	Ask for price

Non-Hodgkin lymphoma Exosome RNA
P241-NH	101Bio	-	Ask for price

Systemic Lupus Erythematosus Exosome RNA
P241-SL	101Bio	-	Ask for price

Uterine Cervical Cancer Exosome RNA
P241-UC	101Bio	-	Ask for price

Uterine Corpus Cancer Exosome RNA
P241-UT	101Bio	-	Ask for price

sRNA-into-Exosome Kit (Electro)
P400	101Bio	-	Ask for price

sRNA-into-Exosome Kit (Chemical)
P401	101Bio	-	Ask for price

Exosome Component 1 (EXOSC1) Antibody
20-abx125829	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx125830	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 3 (EXOSC3) Antibody
20-abx125831	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 1 (EXOSC1) Antibody
20-abx112409	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 10 (EXOSC10) Antibody
20-abx112410	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx112411	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 3 (EXOSC3) Antibody
20-abx112412	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 4 (EXOSC4) Antibody
20-abx112413	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 5 (EXOSC5) Antibody
20-abx112414	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 8 (EXOSC8) Antibody
20-abx112415	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Exosome Component 7 (EXOSC7) Antibody
20-abx124556	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 4 (EXOSC4) Antibody
20-abx124664	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 8 (EXOSC8) Antibody
20-abx318649	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 3 (EXOSC3) Antibody
20-abx312069	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 8 (EXOSC8) Antibody
20-abx003377	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Exosome Component 2 (EXOSC2) Antibody
20-abx003412	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Exosome Component 2 (EXOSC2) Antibody
abx034983-400ul	Abbexa	400 ul	EUR 523

Exosome Component 2 (EXOSC2) Antibody
abx034983-80l	Abbexa	80 µl	EUR 286

Recombinant Human Exosome Component 9
7-05902	CHI Scientific	2µg	Ask for price

Recombinant Human Exosome Component 9
7-05903	CHI Scientific	10µg	Ask for price

Recombinant Human Exosome Component 9
7-05904	CHI Scientific	1mg	Ask for price

Recombinant Human Exosome Component 10
7-05905	CHI Scientific	5µg	Ask for price

Recombinant Human Exosome Component 10
7-05906	CHI Scientific	20µg	Ask for price

Recombinant Human Exosome Component 10
7-05907	CHI Scientific	1mg	Ask for price

Exosome Component 8 (EXOSC8) Antibody
abx031706-400ul	Abbexa	400 ul	EUR 523

Exosome Component 8 (EXOSC8) Antibody
abx031706-80l	Abbexa	80 µl	EUR 286

Exosome Component 4 (EXOSC4) Antibody
abx029390-400ul	Abbexa	400 ul	EUR 523

Exosome Component 4 (EXOSC4) Antibody
abx029390-80l	Abbexa	80 µl	EUR 286

Exosome Component 1 (EXOSC1) Antibody
abx030303-400ul	Abbexa	400 ul	EUR 523

Exosome Component 1 (EXOSC1) Antibody
abx030303-80l	Abbexa	80 µl	EUR 286

Exosome Component 1 (EXOSC1) Antibody
abx232898-100ug	Abbexa	100 ug	EUR 481

Exosome Component 10 (EXOSC10) Antibody
abx232899-100ug	Abbexa	100 ug	EUR 551

Exosome Component 10 (EXOSC10) Antibody
abx232900-100ug	Abbexa	100 ug	EUR 509

Exosome Component 2 (EXOSC2) Antibody
abx232901-100ug	Abbexa	100 ug	EUR 481

Exosome Component 2 (EXOSC2) Antibody
abx232902-100ug	Abbexa	100 ug	EUR 551

Exosome Component 3 (EXOSC3) Antibody
abx232903-100ug	Abbexa	100 ug	EUR 481

Exosome Component 4 (EXOSC4) Antibody
abx232904-100ug	Abbexa	100 ug	EUR 481

Exosome Component 5 (EXOSC5) Antibody
abx232905-100ug	Abbexa	100 ug	EUR 509

Exosome Component 7 (EXOSC7) Antibody
abx232906-100ug	Abbexa	100 ug	EUR 551

Exosome Component 8 (EXOSC8) Antibody
abx232907-100ug	Abbexa	100 ug	EUR 481

Exosome Component 9 (EXOSC9) Antibody
abx232908-100ug	Abbexa	100 ug	EUR 551

Exosome Component 2 (EXOSC2) Antibody
20-abx176346	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Exosome Component 2 (EXOSC2) Antibody
20-abx172308	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Exosome Component 1 (EXOSC1) Antibody
20-abx301763	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 5 (EXOSC5) Antibody
20-abx302857	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome Component 10 (EXOSC10) Antibody
20-abx334343	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exosome precipitation from Plasma + Thrombin
EPStep-T	ImmunoStep	5 ml	EUR 336