The neurodegenerative illness Machado-Joseph illness (MJD), often known as spinocerebellar ataxin-3, impacts neurons of the mind and spinal twine, disrupting management of the motion of muscle groups. Now we have efficiently established the primary transgenic zebrafish (Danio rerio) mannequin of MJD by expressing human ataxin-Three protein containing both 23 glutamines (23Q, wild-type) or 84Q (MJD-causing) inside neurons. Phenotypic characterization of the zebrafish (female and male) revealed that the ataxin-3-84Q zebrafish have decreased survival in contrast with ataxin-3-23Q and develop ataxin-Three neuropathology, ataxin-Three cleavage fragments and motor impairment. Ataxin-3-84Q zebrafish swim shorter distances than ataxin-3-23Q zebrafish as early as 6 days previous, even when expression of the human ataxin-Three protein is proscribed to motor neurons.
This swimming phenotype gives a invaluable readout for drug therapy research. Treating the EGFP-ataxin-3-84Q zebrafish with the calpain inhibitor compound calpeptin decreased ranges of ataxin-Three cleavage fragments, but in addition eliminated all human ataxin-Three protein (confirmed by ELISA) and prevented the early MJD zebrafish motor phenotype. We recognized that this clearance of ataxin-Three protein by calpeptin therapy resulted from a rise in autophagic flux (indicated by decreased p62 ranges and elevated LC3II). Cotreatment with the autophagy inhibitor chloroquine blocked the lower in human ataxin-Three ranges and the improved motion produced by calpeptin therapy. This examine demonstrates that this primary transgenic zebrafish mannequin of MJD is a invaluable instrument for testing potential therapies for MJD. Calpeptin therapy is protecting on this mannequin of MJD and removing of human ataxin-Three by means of macro-autophagy performs an essential function on this useful impact.
SIGNIFICANCE STATEMENT Now we have established the primary transgenic zebrafish mannequin of the neurodegenerative illness MJD, and recognized related illness phenotypes, together with impaired motion from an early age, which can be utilized in fast drug testing research. Now we have discovered that treating the MJD zebrafish with the calpain inhibitor compound calpeptin produces full removing of human ataxin-Three protein, as a consequence of induction of the autophagy high quality management pathway. This improves the motion of the MJD zebrafish. Artificially blocking the autophagy pathway prevents the removing of human ataxin-Three and improved motion produced by calpeptin therapy. These findings point out that induction of autophagy, and removing of ataxin-Three protein, performs an essential function within the protecting results of calpain inhibition for the therapy of MJD.
Disruption of the ATXN1-CIC complicated causes a spectrum of neurobehavioral phenotypes in mice and people.
Acquire-of-function mutations in some genes underlie neurodegenerative circumstances, whereas loss-of-function mutations in the identical genes have distinct phenotypes. This seems to be the case with the protein ataxin 1 (ATXN1), which varieties a transcriptional repressor complicated with capicua (CIC). Acquire of perform of the complicated results in neurodegeneration, however ATXN1-CIC can be important for survival. We got down to perceive the features of the ATXN1-CIC complicated within the creating forebrain and located that dropping this complicated ends in hyperactivity, impaired studying and reminiscence, and irregular maturation and upkeep of upper-layer cortical neurons.
We additionally discovered that CIC exercise within the hypothalamus and medial amygdala modulates social interactions. Knowledgeable by these neurobehavioral options in mouse mutants, we recognized 5 people with de novo heterozygous truncating mutations in CIC who share related medical options, together with mental incapacity, consideration deficit/hyperactivity dysfunction (ADHD), and autism spectrum dysfunction. Our examine demonstrates that lack of ATXN1-CIC complexes causes a spectrum of neurobehavioral phenotypes. The Chk1 protein is crucial for genome integrity upkeep and cell survival in eukaryotic cells. After extended replication stress, Chk1 may be focused for proteasomal degradation to terminate checkpoint signaling after DNA restore finishes. To make sure correct activation of DNA injury checkpoint and DNA restore signaling, a steady-state degree of Chk1 must be retained underneath physiological circumstances.
Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
Epigallocatechin-3-gallate and associated phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-Three in the direction of non-toxic aggregates and stop toxicity in neural cells and Caenorhabditis elegans animal mannequin.
The protein ataxin-3 (ATX3) triggers an amyloid-related neurodegenerative illness when its polyglutamine stretch is expanded past a important threshold. We previously demonstrated that the polyphenol epigallocatechin-3-gallate (EGCG) may redirect amyloid aggregation of a full-length, expanded ATX3 (ATX3-Q55) in the direction of non-toxic, soluble, SDS-resistant aggregates.
Right here, we have now characterised different associated phenol compounds, though smaller in measurement, i.e. (-)-epigallocatechin gallate (EGC), and gallic acid (GA). We analysed the aggregation sample of ATX3-Q55 and of the N-terminal globular Josephin area (JD) by assessing the time course of the soluble protein, as effectively its structural options by FTIR and AFM, within the presence and the absence of the talked about compounds. All of them redirected the aggregation sample in the direction of soluble, SDS-resistant aggregates. Additionally they prevented the looks of ordered side-chain hydrogen bonding in ATX3-Q55, which is the hallmark of polyQ-related amyloids. Molecular docking analyses on the JD highlighted three interacting areas, together with the central, aggregation-prone one. All three compounds sure to every of them, though with completely different patterns.
 Antibody) Ataxin 7 (ATXN7) Antibody |
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| 20-abx148459 | Abbexa |
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Ataxin 7 (ATXN7) Antibody |
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| abx029159-400ul | Abbexa | 400 ul | EUR 523 |
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Ataxin 7 (ATXN7) Antibody |
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| abx029159-80l | Abbexa | 80 µl | EUR 286 |
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Ataxin 7 (ATXN7) Antibody |
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| 20-abx338870 | Abbexa |
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 Antibody (HRP)) Ataxin 7 (ATXN7) Antibody (HRP) |
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| 20-abx334734 | Abbexa |
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 Antibody (FITC)) Ataxin 7 (ATXN7) Antibody (FITC) |
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| 20-abx334735 | Abbexa |
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 Antibody (Biotin)) Ataxin 7 (ATXN7) Antibody (Biotin) |
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| 20-abx334736 | Abbexa |
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 Ataxin 7 Blocking Peptide |
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| 20-abx161290 | Abbexa |
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 Antibody) Ataxin 7 Like 1 (ATXN7L1) Antibody |
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| 20-abx325156 | Abbexa |
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 Recombinant Human Ataxin-3 |
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| 7-04462 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04463 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04464 | CHI Scientific | 1mg | Ask for price |
 Antibody) Ataxin-7-Like Protein 2 (ATXN7L2) Antibody |
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| abx219541-100ug | Abbexa | 100 ug | EUR 439 |
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Ataxin-7-Like Protein 2 (ATXN7L2) Antibody |
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| 20-abx121022 | Abbexa |
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 Antibody) Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx121023 | Abbexa |
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 Antibody) Ataxin-7-Like Protein 1 (ATXN7L1) Antibody |
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| 20-abx121291 | Abbexa |
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| abx037189-100ug | Abbexa | 100 ug | EUR 391 |
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Ataxin-7-Like Protein 1 (ATXN7L1) Antibody |
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| 20-abx148460 | Abbexa |
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx301379 | Abbexa |
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Ataxin-7-Like Protein 1 (ATXN7L1) Antibody |
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| 20-abx301749 | Abbexa |
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 Antibody (HRP)) Ataxin 7 Like 1 (ATXN7L1) Antibody (HRP) |
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| 20-abx312252 | Abbexa |
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 Antibody (FITC)) Ataxin 7 Like 1 (ATXN7L1) Antibody (FITC) |
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| 20-abx312253 | Abbexa |
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 Antibody (Biotin)) Ataxin 7 Like 1 (ATXN7L1) Antibody (Biotin) |
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| 20-abx312254 | Abbexa |
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 Antibody (HRP)) Ataxin 7 Like 3 (ATXN7L3) Antibody (HRP) |
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| 20-abx306773 | Abbexa |
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 Antibody (FITC)) Ataxin 7 Like 3 (ATXN7L3) Antibody (FITC) |
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| 20-abx306774 | Abbexa |
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 Antibody (Biotin)) Ataxin 7 Like 3 (ATXN7L3) Antibody (Biotin) |
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| 20-abx306775 | Abbexa |
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 ELISA kit) Human Ataxin 7(ATXN7) ELISA kit |
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| E01A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7(ATXN7) ELISA kit |
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| E01A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7(ATXN7) ELISA kit |
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| E01A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Ataxin 7(ATXN7) ELISA kit |
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| E02A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7(ATXN7) ELISA kit |
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| E02A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7(ATXN7) ELISA kit |
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| E02A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Ataxin 7(ATXN7) ELISA kit |
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| E06A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7(ATXN7) ELISA kit |
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| E06A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7(ATXN7) ELISA kit |
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| E06A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Ataxin 7(ATXN7) ELISA kit |
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| E03A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7(ATXN7) ELISA kit |
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| E03A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7(ATXN7) ELISA kit |
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| E03A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rabbit Ataxin 7(ATXN7) ELISA kit |
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| E04A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 7(ATXN7) ELISA kit |
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| E04A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 7(ATXN7) ELISA kit |
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| E04A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Pig Ataxin 7(ATXN7) ELISA kit |
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| E07A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 7(ATXN7) ELISA kit |
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| E07A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 7(ATXN7) ELISA kit |
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| E07A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Dog Ataxin 7(ATXN7) ELISA kit |
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| E08A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 7(ATXN7) ELISA kit |
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| E08A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 7(ATXN7) ELISA kit |
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| E08A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Monkey Ataxin 7(ATXN7) ELISA kit |
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| E09A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 7(ATXN7) ELISA kit |
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| E09A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 7(ATXN7) ELISA kit |
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| E09A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Human Ataxin- 7, ATXN7 ELISA KIT |
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| ELI-11388h | Lifescience Market | 96 Tests | EUR 824 |
 Mouse Ataxin- 7, Atxn7 ELISA KIT |
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| ELI-24059m | Lifescience Market | 96 Tests | EUR 865 |
ELISA Kit) Human Ataxin 7(ATXN7)ELISA Kit |
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| QY-E01557 | Qayee Biotechnology | 96T | EUR 361 |
 ELISA kit) Guinea pig Ataxin 7(ATXN7) ELISA kit |
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| E05A1770-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 7(ATXN7) ELISA kit |
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| E05A1770-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 7(ATXN7) ELISA kit |
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| E05A1770-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Ataxin 3 antibody |
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| 22437-100ul | SAB | 100ul | EUR 390 |
Ataxin 3 antibody |
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| 70R-13630 | Fitzgerald | 100 ul | EUR 457 |
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Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody |
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 Ataxin 2 antibody |
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| 70R-50365 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal Ataxin 2 antibody |
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 Ataxin 10 antibody |
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| 70R-50914 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal Ataxin 10 antibody |
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 Ataxin 1 Antibody |
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| AF6347 | Affbiotech | 200ul | EUR 304 |
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Description: Ataxin 1 Antibody detects endogenous levels of total Ataxin 1. |
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Ataxin 1 Antibody |
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| ABF6347 | Lifescience Market | 100 ug | EUR 438 |
 Anti-Cytokeratin 7 |
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| DB051RTU-7 | DB Biotech | 7 ml | EUR 204 |
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Description: rabbit monospecific clonal antibodies for ihc-p application; prediluted (ready to use) |
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 ELISA kit) Human Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E01A1771-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E01A1771-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E01A1771-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Human Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E01A1772-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E01A1772-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E01A1772-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E01A1773-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E01A1773-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E01A1773-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E02A1771-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E02A1771-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E02A1771-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E02A1772-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E02A1772-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E02A1772-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E02A1773-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E02A1773-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E02A1773-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E06A1771-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E06A1771-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E06A1771-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E06A1772-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E06A1772-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E06A1772-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E06A1773-192T | B-Gene | 192 tests | EUR 1270 |
|
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E06A1773-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
|
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E06A1773-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
|
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E03A1771-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E03A1771-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7 like protein 1(ATXN7L1) ELISA kit |
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| E03A1771-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 1(ATXN7L1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E03A1772-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E03A1772-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7 like protein 2(ATXN7L2) ELISA kit |
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| E03A1772-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 2(ATXN7L2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E03A1773-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 7 like protein 3(ATXN7L3) ELISA kit |
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| E03A1773-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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This would possibly account for his or her functionality to stop amyloidogenesis. Saturation switch distinction NMR experiments additionally confirmed EGCG and EGC binding to monomeric JD. ATX3-Q55 pre-incubation with any of the three compounds prevented its calcium-influx-mediated cytotoxicity in the direction of neural cells. Lastly, all of the phenols considerably diminished toxicity in a transgenic Caenorhabditis elegans pressure expressing an expanded ATX3. General, our outcomes present that the three polyphenols act in a considerably related method. GA, nonetheless, may be extra appropriate for antiamyloid therapies as a consequence of its less complicated construction and better chemical stability.