Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

The RNA-binding protein Ataxin-2 binds to and stabilizes numerous mRNA sequences, together with that of the transactive response DNA binding protein 43 kDa (TDP-43). Ataxin-2 is moreover concerned in a number of processes requiring translation corresponding to germline formation, long run habituation and circadian rhythm formation. Nevertheless, it has but to be unambiguously demonstrated that Ataxin-2 is definitely concerned in activating the interpretation of its goal mRNAs. Right here we offer direct proof from a polysome profile evaluation displaying that Ataxin-2 enhances translation of goal mRNAs.

Our lately established technique for transcriptional pulse-chase evaluation beneath situations of suppressing deadenylation revealed that Ataxin-2 promotes post-transcriptional polyadenylation of the goal mRNAs. Moreover, Ataxin-2 binds to a poly(A) binding protein PABPC1 and a noncanonical poly(A) polymerase PAPD4 by way of its intrinsically disordered area (906-1095 aa) to recruit PAPD4 to the targets. Posttranscriptional polyadenylation by Ataxin-2 explains not solely the way it prompts translation but additionally stabilizes goal mRNAs, together with TDP-43 mRNA.

Ataxin-2 is thought to be a potent modifier of TDP-43 proteinopathies and to play a causative position within the neurodegenerative illness Spinocerebellar ataxia sort 2, so these findings recommend that Ataxin-2-induced cytoplasmic polyadenylation and activation of translation would possibly influence neurodegeneration (i.e., TDP-43 proteinopathies) and this course of may very well be a therapeutic goal for Ataxin-2-related neurodegenerative issues.

Machado-Joseph Deubiquitinases: From Mobile Capabilities to Potential Remedy Targets

Ubiquitination is named necessary post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with capabilities of modulating the ubiquitination course of, are a household with about 100 proteins. They primarily operate by slicing ubiquitin chains of the substrates. The Machado-Joseph domain-containing proteases (MJDs) is among the sub-families of DUBs, consisting of 4 members, particularly, Ataxin-3, Ataxin-3L, JOSD1, and JOSD2. Latest research have supplied new insights into organic capabilities of MJDs within the development of Machado-Joseph illness or most cancers illnesses. On this assessment, we summarized the mobile capabilities and regulatory mechanisms of MJDs in Machado-Joseph illness and most cancers pathways.
Moreover, we summarized MJDs genetic alterations in numerous human cancers by exploring the general public databases (cBioportal). The purpose of this assessment is to supply a complete account primarily based on our present data about rising insights into MJDs in physiology and illness, which could make clear basic organic questions and promise to supply a possible goal for therapeutic intervention. The panorama of polyQ SCAs therapeutic targets and methods contains (1) the mutant genes and proteins themselves, (2) enhancement of endogenous protein high quality management responses, (3) irregular protein-protein interactions of the mutant proteins, (4) disturbed neuronal operate, (5) mitochondrial operate, power availability and oxidative stress, and (6) glial dysfunction, development issue or hormone imbalances.
Challenges embrace gaining a clearer definition of therapeutic targets for the medication in scientific improvement, the invention of novel drug-like molecules for difficult key targets, and the attainment of a stronger translation of preclinical findings to the clinic.
Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

Main Enhancements in Robustness and Effectivity through the Screening of Novel Enzyme Effectors by the 3-Level Kinetics Assay

The throughput stage presently reached by computerized liquid dealing with and assay monitoring strategies is anticipated to facilitate the invention of recent modulators of enzyme exercise. Even handed and reliable methods to interpret huge quantities of knowledge are, nonetheless, required to successfully reply this problem. Right here, the 3-point technique of kinetic evaluation is proposed as a method to considerably improve the hit success charges and reduce the variety of falsely recognized compounds (false positives). On this post-Michaelis-Menten strategy, every screened response is probed in three completely different events, none of which essentially coincide with the preliminary interval of fixed velocity.
Enzymology rules somewhat than subjective standards are utilized to establish undesirable outliers corresponding to assay artifacts, after which to precisely distinguish true enzyme modulation results from false positives. The exclusion and choice standards are outlined primarily based on the 3-point response coordinates, whose relative positions alongside the time-courses might change from properly to properly or from plate to plate, if mandatory. The robustness and effectivity of the brand new technique is illustrated throughout a small drug repurposing screening of potential modulators of the deubiquinating exercise of ataxin-3, a protein implicated in Machado-Joseph illness. Apparently, intractable Z components are drastically enhanced after (1) eliminating spurious outcomes, (2) enhancing the normalization technique, and (3) growing the assay resilience to systematic and random variability. Numerical simulations additional show that the 3-point evaluation is very delicate to particular, catalytic, and slow-onset modulation results which are significantly troublesome to detect by typical endpoint assays.

Ataxin-3
PR27235 2 ug
EUR 229.2

Ataxin-3 Protein
20-abx262861
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin- 3, ATXN3 ELISA KIT
ELI-11466h 96 Tests
EUR 988.8

Human Ataxin 3(ATXN3)ELISA Kit
QY-E01558 96T
EUR 433.2

Ataxin 3 protein
30R-1344 50 ug
EUR 366
Description: Purified recombinant Human Ataxin 3 protein

Ataxin 3 antibody
70R-13630 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody

Ataxin 3 antibody
22437-100ul 100ul
EUR 468

Ataxin 3 Antibody
DF6375 200ul
EUR 420

Human Ataxin 3 / ATX3 (ATXN3) ELISA Kit
abx259421-96tests 96 tests
EUR 990

Ataxin-3 (pS256) Antibody
abx148457-100ug 100 ug
EUR 526.8

Ataxin 3 Rabbit pAb
A12992-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb
A12992-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb
A12992-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb
A12992-50ul 50 ul
EUR 267.6

Ataxin 3 Rabbit pAb
A1243-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb
A1243-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb
A1243-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb
A1243-50ul 50 ul
EUR 267.6

Human Ataxin 2 ELISA kit
E01A0301-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 2 ELISA kit
E01A0301-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 1 ELISA kit
E01A0540-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 1 ELISA kit
E01A0540-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 1 ELISA kit
E01A0540-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ataxin 2 ELISA KIT|Human
EF007956 96 Tests
EUR 826.8

Ataxin 3 Antibody / ATXN3
F55027-0.08ML 0.08 ml
EUR 140.25
Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers.

Ataxin 3 Antibody / ATXN3
F55027-0.4ML 0.4 ml
EUR 322.15
Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers.

Ataxin 3 Antibody / ATXN3
R32137 100 ug
EUR 356.15
Description: ATXN3 (Ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 ranges in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation. Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.

Human Ataxin-3-Like Protein (ATXN3L) ELISA Kit
20-abx385970
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Ataxin 1 (ATXN1) Protein
20-abx065471
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Ataxin 10 (ATXN10) Protein
20-abx166893
  • EUR 811.20
  • EUR 343.20
  • EUR 2498.40
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human ATXN10/ Ataxin-10 ELISA Kit
E0236Hu 1 Kit
EUR 726

Ataxin 3 Polyclonal Antibody
27857-100ul 100ul
EUR 302.4

Ataxin 3 Polyclonal Antibody
27857-50ul 50ul
EUR 224.4

Ataxin 3 Polyclonal Antibody
A70452
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

Ataxin-3 Fluorescent Assay Kit
78044 96 rxns.
EUR 765
Description: The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. 

Human Ataxin 1 (ATXN1) CLIA Kit
abx196467-96tests 96 tests
EUR 990

Human Ataxin 10 (ATXN10) CLIA Kit
20-abx494169
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Ataxin- 2, ATXN2 ELISA KIT
ELI-34718h 96 Tests
EUR 988.8

Human Ataxin- 8, ATXN8 ELISA KIT
ELI-48889h 96 Tests
EUR 988.8

Human Ataxin 1 (ATXN1) ELISA Kit
abx572392-96tests 96 tests
EUR 801.6

Human Ataxin 2 (ATXN2) ELISA Kit
abx351338-96tests 96 tests
EUR 848.4

Human Ataxin 1 (ATXN1) ELISA Kit
DLR-ATXN1-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Ataxin 1 (ATXN1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Ataxin 1 (ATXN1) ELISA Kit
DLR-ATXN1-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Ataxin 1 (ATXN1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Ataxin 7(ATXN7) ELISA kit
E01A1770-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 7(ATXN7) ELISA kit
E01A1770-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 7(ATXN7) ELISA kit
E01A1770-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7(ATXN7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 8(ATXN8) ELISA kit
E01A1774-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 8(ATXN8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 8(ATXN8) ELISA kit
E01A1774-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 8(ATXN8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 8(ATXN8) ELISA kit
E01A1774-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 8(ATXN8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin- 7, ATXN7 ELISA KIT
ELI-11388h 96 Tests
EUR 988.8

Human Ataxin- 1, ATXN1 ELISA KIT
ELI-11425h 96 Tests
EUR 988.8

Human Ataxin 8(ATXN8)ELISA Kit
QY-E01556 96T
EUR 433.2

Human Ataxin 7(ATXN7)ELISA Kit
QY-E01557 96T
EUR 433.2

Human Ataxin 2(ATXN2)ELISA Kit
QY-E01559 96T
EUR 433.2

Human Ataxin 1(ATXN1)ELISA Kit
QY-E01561 96T
EUR 433.2

Human Ataxin 1 (ATXN1) ELISA Kit
RDR-ATXN1-Hu-48Tests 48 Tests
EUR 600

Human Ataxin 1 (ATXN1) ELISA Kit
RDR-ATXN1-Hu-96Tests 96 Tests
EUR 830.4

Human Ataxin 1 (ATXN1) ELISA Kit
RD-ATXN1-Hu-48Tests 48 Tests
EUR 573.6

Human Ataxin 1 (ATXN1) ELISA Kit
RD-ATXN1-Hu-96Tests 96 Tests
EUR 794.4

Human Ataxin 10 (ATXN10) ELISA Kit
abx555491-96tests 96 tests
EUR 886.8

Human Ataxin- 10, ATXN10 ELISA KIT
ELI-50020h 96 Tests
EUR 988.8

Human Ataxin 10 (ATXN10) ELISA Kit
20-abx156823
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Ataxin 10(ATXN10) ELISA kit
E01A1767-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 10(ATXN10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 10(ATXN10) ELISA kit
E01A1767-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 10(ATXN10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 10(ATXN10) ELISA kit
E01A1767-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 10(ATXN10) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 10 (ATXN10) ELISA Kit
SED248Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ataxin 10 (ATXN10) in tissue homogenates, cell lysates and other biological fluids.

Human Ataxin 10 (ATXN10) ELISA Kit
SED248Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ataxin 10 (ATXN10) in tissue homogenates, cell lysates and other biological fluids.

Human Ataxin 10 (ATXN10) ELISA Kit
SED248Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ataxin 10 (ATXN10) in tissue homogenates, cell lysates and other biological fluids.

Human Ataxin 10 (ATXN10) ELISA Kit
SED248Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ataxin 10 (ATXN10) in tissue homogenates, cell lysates and other biological fluids.

Human Ataxin 10 (ATXN10) ELISA Kit
4-SED248Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Ataxin 10 (ATXN10) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Ataxin 10(ATXN10)ELISA Kit
QY-E01560 96T
EUR 433.2

Ataxin-3 (Phospho-Ser256) Antibody
12574-100ul 100ul
EUR 302.4

Ataxin-3 (Phospho-Ser256) Antibody
12574-50ul 50ul
EUR 224.4

Human ATXN1(Ataxin 1) ELISA Kit
EH2682 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx225054
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx318334
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody
abx036768-100ug 100 ug
EUR 469.2

Ataxin 3 / ATX3 (ATXN3) Antibody
abx038360-100ug 100 ug
EUR 469.2

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx001155
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx111106
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit
E01A1773-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit
E01A1773-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 7 like protein 3(ATXN7L3) ELISA kit
E01A1773-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 7 like protein 3(ATXN7L3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin- 7- like protein 3, ATXN7L3 ELISA KIT
ELI-12005h 96 Tests
EUR 988.8

Ataxin-2 Antibody
R31210 100 ug
EUR 356.15
Description: Ataxin-2, the protein encoded by the ATXN2 gene, contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2(SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and overexpression leads to accumulation of T-plastin in mammalian cells.

Ataxin- 3 (Phospho- Ser256) Antibody
ABF8242 100 ug
EUR 525.6

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

CLIA kit for Human ATXN1 (Ataxin 1)
E-CL-H0422 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human ATXN1 (Ataxin 1) in samples from Serum, Plasma, Cell supernatant

Human Ataxin- 1- like, ATXN1L ELISA KIT
ELI-48888h 96 Tests
EUR 988.8

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human ATXN1 (Ataxin 1)
E-EL-H0519 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ATXN1 (Ataxin 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ATXN2 (Ataxin 2)
E-EL-H0520 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ATXN2 (Ataxin 2) in samples from Serum, Plasma, Cell supernatant

Ataxin 2 antibody
70R-50365 100 ul
EUR 292.8
Description: Purified Polyclonal Ataxin 2 antibody

Ataxin 10 antibody
70R-50914 100 ul
EUR 292.8
Description: Purified Polyclonal Ataxin 10 antibody

Ataxin 1 Antibody
ABF6347 100 ug
EUR 525.6

Ataxin 1 Antibody
AF6347 200ul
EUR 420

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin- 3, Atxn3 ELISA KIT
ELI-11387m 96 Tests
EUR 1038

Human Putative ataxin- 3- like protein, ATXN3L ELISA KIT
ELI-12019h 96 Tests
EUR 988.8

ELISA kit for Human ATXN10 (Ataxin 10)
ELK5092 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Ataxin 10 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Ataxin-3-Like Protein (ATXN3L) Antibody
abx230742-100ug 100 ug
EUR 577.2

Ataxin-3-Like Protein (ATXN3L) Antibody
abx230743-100ug 100 ug
EUR 610.8

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ataxin 3 Polyclonal Conjugated Antibody
C27857 100ul
EUR 476.4

Chicken Ataxin- 3, ATXN3 ELISA KIT
ELI-24058c 96 Tests
EUR 1113.6

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)
20-abx303178
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)
20-abx303179
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody (Biotin)
20-abx303180
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Ataxin-2-Like Protein (ATXN2L) ELISA Kit
abx259422-96tests 96 tests
EUR 990

Ataxin-2 Antibody / ATXN2
R32313 100 ug
EUR 356.15
Description: Ataxin-2, or ATX2, protein is encoded by the ATXN2 gene and contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2 (SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and that overexpression of ataxin-2 leads to accumulation of T-plastin in mammalian cells.

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
abx037189-100ug 100 ug
EUR 469.2

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
20-abx121023
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
20-abx301379
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin-1 Polyclonal Antibody
ABP50719-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-1 Polyclonal Antibody
ABP50719-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-1 Polyclonal Antibody
ABP50719-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-2 Polyclonal Antibody
ABP50720-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-2 Polyclonal Antibody
ABP50720-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-2 Polyclonal Antibody
ABP50720-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-1 Polyclonal Antibody
40621-100ul 100ul
EUR 302.4

Ataxin-1 Polyclonal Antibody
40621-50ul 50ul
EUR 224.4

Ataxin-2 Polyclonal Antibody
40622-100ul 100ul
EUR 302.4

Ataxin-2 Polyclonal Antibody
40622-50ul 50ul
EUR 224.4

Ataxin-1 Polyclonal Antibody
ES1718-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Ataxin-1 Polyclonal Antibody
ES1718-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Ataxin-2 Polyclonal Antibody
ES1719-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Ataxin-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Though attributable to an analogous mutation, polyglutamine issues are distinct, implicating non-polyglutamine areas of illness proteins as regulators of pathogenesis. SCA3 is attributable to polyglutamine enlargement in ataxin-3. To find out the position of ataxin-3’s non-polyglutamine domains in illness, we utilized a brand new, allelic collection of Drosophila melanogaster.

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