Mechanical stress promotes angiogenesis by means of fibroblast exosomes
Background: Mechanical stress can induce a number of purposeful modifications in vascular endothelial cells, together with proliferation, differentiation, and migration. Moreover, human fibroblasts are inclined to exterior mechanical stress. On this work, we investigated whether or not mechanical stress can induce exosome secretion from fibroblasts to modulate angiogenesis.
Strategies: A CCK-Eight cell proliferation assay was used to find out mechanical parameters. Then, exosomes from fibroblasts had been remoted and characterised with regard to focus and markers. We subsequently explored the impact of exosomes on proliferation, migration, and angiogenesis. Moreover, high-throughput sequencing was used to display screen differentially expressed miRNAs within the mechanical stress-induced exosomes.
Outcomes: A static stretching of 15% considerably enhanced the cell viability of the fibroblasts (p < 0.05) and considerably induced the secretion of exosomes from the fibroblasts, which had a stronger internalization capacity. Additional experiments demonstrated that the presence of static stretching-induced exosomes considerably elevated cell proliferation, migration, and angiogenesis by regulating the Erk1/2 signaling pathway. Moreover, 12 up-regulated and 12 down-regulated candidate miRNAs had been discriminated within the static stretching-induced exosomes.
Conclusion: Our findings conclusively exhibit that static stretching-derived exosomes from fibroblasts promote angiogenesis by means of differentially expressed miRNAs, offering novel insights into the molecular mechanism by which mechanical stress influences angiogenesis.
ataxin
 EZLabel? Antibody HRP Labeling Kit |
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| K4310-1 | Biovision | EUR 697 | |
 EZLabel? Antibody RPE Labeling Kit |
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| K4313-1 | Biovision | EUR 805 | |
 Antibody Labeling Kit) Allophycocyanin (APC) Antibody Labeling Kit |
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| 20-abx098280 | Abbexa |
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 Antibody Labeling Kit) Phycoerythrin (PE) Antibody Labeling Kit |
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| 20-abx098281 | Abbexa |
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 labeling) Mix-n-Stain CF350 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92230 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405S Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92231 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405M Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92232 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF488A Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92233 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF555 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92234 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF568 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92235 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF594 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92236 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF633 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92237 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF647 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92238 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660C Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92239 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92240 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF750 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92241 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF770 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92242 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660R Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92243 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain Biotin Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92244 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF640R Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92245 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680R Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92246 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF543 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92247 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF790 Antibody Labeling Kit, 1x(50-100ug) labeling |
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| 92248 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF350 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92250 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405S Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92251 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405M Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92252 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF488A Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92253 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF555 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92254 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF568 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92255 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF594 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92256 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF633 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92257 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF640R Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92258 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF647 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92259 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660C Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92260 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660R Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92261 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92262 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680R Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92263 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF750 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92264 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF770 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92265 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain Biotin Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92266 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF543 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92267 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF790 Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92268 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF350 Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92270 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405S Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92271 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF405M Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92272 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF488A Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92273 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF555 Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92274 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF568 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92275 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF594 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92276 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF633 Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92277 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF640R Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92278 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF647 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92279 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660C Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92280 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF660R Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92281 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680 Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92282 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF680R Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92283 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF750 Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92284 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF770 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92285 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain Biotin Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92286 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF543 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92287 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF790 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92288 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF532 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92289 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF532 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92290 | Biotium | 1Kit | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1Kit |
|||
 labeling) Mix-n-Stain CF532 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92291 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain FITC Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92294 | Biotium | 1KIT | EUR 120 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain FITC Antibody Labeling Kit, 1x(20-50ug) labeling |
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| 92295 | Biotium | 1KIT | EUR 132 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain FITC Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92296 | Biotium | 1KIT | EUR 143 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain RPE Antibody Labeling Kit, 1x(5-20ug) labeling |
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| 92297 | Biotium | 1KIT | EUR 166 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain RPE Antibody Labeling Kit, 1x(25-50ug) labeling |
|||
| 92298 | Biotium | 1KIT | EUR 177 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain RPE Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92299 | Biotium | 1KIT | EUR 189 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain HRP Antibody Labeling Kit, 1x(10-20ug) labeling |
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| 92300 | Biotium | 1KIT | EUR 155 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain HRP Antibody Labeling Kit, 1x(25-50ug) labeling |
|||
| 92301 | Biotium | 1KIT | EUR 166 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain HRP Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92302 | Biotium | 1KIT | EUR 177 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF405L Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92303 | Biotium | 1KIT | EUR 161 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF405L Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92304 | Biotium | 1Kit | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1Kit |
|||
 labeling) Mix-n-Stain CF405L Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92305 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain APC Antibody Labeling Kit, 1x(25-50ug) labeling |
|||
| 92306 | Biotium | 1KIT | EUR 177 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain APC Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92307 | Biotium | 1KIT | EUR 189 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain PerCP Antibody Labeling Kit, 1x(25-50ug) labeling |
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| 92308 | Biotium | 1KIT | EUR 177 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain PerCP Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92309 | Biotium | 1KIT | EUR 189 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF430 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92316 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF430 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92317 | Biotium | 1Kit | EUR 195 |
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Description: Minimum order quantity: 1 unit of 1Kit |
|||
 labeling) Mix-n-Stain CF430 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92318 | Biotium | 1KIT | EUR 207 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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 labeling) Mix-n-Stain CF440 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92319 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF440 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92320 | Biotium | 1Kit | EUR 195 |
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Description: Minimum order quantity: 1 unit of 1Kit |
|||
 labeling) Mix-n-Stain CF440 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92321 | Biotium | 1KIT | EUR 207 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF450 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92322 | Biotium | 1KIT | EUR 185 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain CF450 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92323 | Biotium | 1Kit | EUR 195 |
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Description: Minimum order quantity: 1 unit of 1Kit |
|||
 labeling) Mix-n-Stain CF450 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92324 | Biotium | 1KIT | EUR 207 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
 labeling) Mix-n-Stain DNP Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92325 | Biotium | 1KIT | EUR 172 |
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Description: Minimum order quantity: 1 unit of 1KIT |
|||
MSC-derived exosomes promote restoration from traumatic mind damage by way of microglia/macrophages in rat
Traumatic mind damage (TBI) is a number one reason behind morbidity and mortality in younger people worldwide. There may be presently no efficient scientific therapy for TBI, however mesenchymal stem cell-derived exosomes have exhibited promising therapeutic results.
On this examine, we carried out intracerebroventricular microinjection of human adipose mesenchymal stem cell (hADSC)-derived exosomes (hADSC-ex) in a weight-drop-induced TBI rat mannequin. We discovered that hADSC-ex promoted purposeful restoration, suppressed neuroinflammation, lowered neuronal apoptosis, and elevated neurogenesis in TBI rats.
The therapeutic results of hADSC-ex had been akin to these of hADSC. Sequential in vivo imaging revealed growing aggregation of DiR-labeled hADSC-ex within the lesion space. Immunofluorescent staining of coronal mind sections and first combined neural cell cultures revealed distinct overlap between CM-DiI-labeled hADSC-ex and microglia/macrophages, indicating that hADSC-ex had been primarily taken up by microglia/macrophages.
In a lipopolysaccharide-induced inflammatory mannequin, hADSC-ex suppressed microglia/macrophage activation by inhibiting nuclear issue κB and P38 mitogen-activated protein kinase signaling. These information counsel that hADSC-ex particularly enter microglia/macrophages and suppress their activation throughout mind damage, thereby inhibiting irritation and facilitating purposeful restoration.
In addition they supply new perception into the mobile concentrating on, uptake and migration of hADSC-ex, and supply a theoretical foundation for brand spanking new therapeutic methods for central nervous system ailments.
The Position of Exosomes in Stemness and Neurodegenerative Ailments-Chemoresistant-Most cancers Therapeutics and Phytochemicals
- Exosomes exhibit a variety of organic properties and features within the residing organisms. They’re nanometric automobiles and used for delivering medication, as they’re biocompatible and minimally immunogenic. Exosomal secretions derived from most cancers cells contribute to metastasis, immortality, angiogenesis, tissue invasion, stemness and chemo/radio-resistance.
- Exosome-derived microRNAs (miRNAs) and lengthy non-coding RNAs (lnc RNAs) are concerned within the pathophysiology of cancers and neurodegenerative ailments. As an illustration, exosomes derived from mesenchymal stromal cells, astrocytes, macrophages, and acute myeloid leukemia (AML) cells are concerned within the most cancers development and stemness as they induce chemotherapeutic drug resistance in a number of most cancers cells.
- This evaluation lined the current analysis advances in understanding the position of exosomes in most cancers development, metastasis, angiogenesis, stemness and drug resistance by illustrating the modulatory results of exosomal cargo (ex. miRNA, lncRNAs, and so on.) on cell signaling pathways concerned in most cancers development and most cancers stem cell progress and growth. Current stories have implicated exosomes even within the therapy of a number of cancers.
- As an illustration, exosomes-loaded with novel anti-cancer medication reminiscent of phytochemicals, tumor-targeting proteins, anticancer peptides, nucleic acids are identified to intrude with drug resistance pathways in a number of most cancers cell traces. As well as, this evaluation depicted the necessity to develop exosome-based novel diagnostic biomarkers for early detection of cancers and neurodegenerative illness.
- Moreover, the position of exosomes in stroke and oxidative stress-mediated neurodegenerative ailments together with Alzheimer’s illness (AD), and Parkinson’s illness (PD) can also be mentioned on this article..
 Anti-human CD5 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00480-Biotin | BosterBio | 100µg | EUR 233 |
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Description: Mouse Monoclonal human CD5 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD45 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00555-Biotin | BosterBio | 100µg | EUR 152 |
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Description: Mouse Monoclonal human CD45 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00570-Biotin | BosterBio | 100µg | EUR 233 |
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Description: Mouse Monoclonal human CD2 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD71 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00591-Biotin | BosterBio | 100µg | EUR 245 |
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Description: Mouse Monoclonal human CD71 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD62L Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00652-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD62L Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD59 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00914-Biotin | BosterBio | 100µg | EUR 265 |
|
Description: Mouse Monoclonal human CD59 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD117 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01335-Biotin | BosterBio | 100μg | EUR 224 |
|
Description: Mouse Monoclonal human CD117 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD32 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01450-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD32 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD90 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01818-Biotin | BosterBio | 100µg | EUR 268 |
|
Description: Mouse Monoclonal human CD90 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD7 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01974-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD7 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
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 Anti-human CD235a Monoclonal Antibody Biotin Conjugated, Flow Validated |
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| FC02184-Biotin | BosterBio | 100µg | EUR 245 |
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Description: Mouse Monoclonal human CD235a Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
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 Anti-human CD8 Monoclonal Antibody Biotin Conjugated, Flow Validated |
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| FC02236-Biotin | BosterBio | 100µg | EUR 152 |
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Description: Mouse Monoclonal human CD8 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
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 Anti-Human VEGI Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC02402-Biotin | BosterBio | Various Sizes | EUR 497 |
|
Description: Mouse Monoclonal Human VEGI Antibody Biotin Conjugated, Flow Validated. Validated in WB and tested in Human. |
|||
 Anti-human CD3 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC02675-Biotin | BosterBio | 100µg | EUR 152 |
|
Description: Mouse Monoclonal human CD3 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD20 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC03780-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD20 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
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 Anti-human CD10 Monoclonal Antibody Biotin Conjugated, Flow Validated |
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| FC04065-Biotin | BosterBio | 100µg | EUR 189 |
|
Description: Mouse Monoclonal human CD10 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD57 Monoclonal Antibody Biotin Conjugated, Flow Validated |
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| FC09548-Biotin | BosterBio | 100µg | EUR 245 |
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Description: Mouse Monoclonal human CD57 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
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Mix-n-Stain Biotin Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92244 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain Biotin Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92266 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain Biotin Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92286 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
 Anti-human HLA-DR Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00568-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human HLA-DR Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD55/Daf Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC00910-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD55/Daf Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01508-Biotin | BosterBio | 100µg | EUR 234 |
|
Description: Mouse Monoclonal human CD33/Siglec 3 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Anti-human CD22/Siglec 2 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01572-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal human CD22/Siglec 2 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Antibody (Biotin)) Exosome Component 8 (EXOSC8) Antibody (Biotin) |
|||
| 20-abx310196 | Abbexa |
|
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 Antibody (Biotin)) Exosome Component 5 (EXOSC5) Antibody (Biotin) |
|||
| 20-abx311413 | Abbexa |
|
|
 Antibody (Biotin)) Exosome Component 3 (EXOSC3) Antibody (Biotin) |
|||
| 20-abx312072 | Abbexa |
|
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 Antibody (Biotin)) Exosome Component 1 (EXOSC1) Antibody (Biotin) |
|||
| 20-abx312488 | Abbexa |
|
|
 Antibody (Biotin)) Exosome Component 10 (EXOSC10) Antibody (Biotin) |
|||
| 20-abx335642 | Abbexa |
|
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 Antibody (Biotin)) Exosome complex exonuclease DIS3 (DIS3) Antibody (Biotin) |
|||
| 20-abx335639 | Abbexa |
|
|
 Mouse anti-human CD7 Monoclonal Antibody Biotin Conjugated, Flow Validated |
|||
| FC01974-1-Biotin | BosterBio | 100µg | EUR 233 |
|
Description: Mouse Monoclonal Mouse human CD7 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human. |
|||
 Psoriasis Exosome |
|||
| P141-PS | 101Bio | - | Ask for price |
 Labeling Tape, Blue |
|||
| TP001B | Bio Basic | 1ROLLS, 1 UNIT | EUR 53.68 |
 Labeling Tape, Red |
|||
| TP002R | Bio Basic | 1ROLLS, 1 UNIT | EUR 53.68 |
 Labeling Tape, White |
|||
| TP003W | Bio Basic | 1ROLLS, 1 UNIT | EUR 53.68 |
 Labeling Tape, Yellow |
|||
| TP004Y | Bio Basic | 1ROLLS, 1 UNIT | EUR 53.68 |
 Leukemia - ALL Exosome |
|||
| P141-ALL | 101Bio | - | Ask for price |
 Leukemia - AML Exosome |
|||
| P141-AML | 101Bio | - | Ask for price |
 Bladder Cancer Exosome |
|||
| P141-BL | 101Bio | - | Ask for price |
 Breast Cancer Exosome |
|||
| P141-BR | 101Bio | - | Ask for price |
 Leukemia - CLL Exosome |
|||
| P141-CLL | 101Bio | - | Ask for price |
 Leukemia - CML Exosome |
|||
| P141-CML | 101Bio | - | Ask for price |
 Colorectal Cancer Exosome |
|||
| P141-CO | 101Bio | - | Ask for price |
 Crohn's Disease Exosome |
|||
| P141-CR | 101Bio | - | Ask for price |
 Kidney Cancer Exosome |
|||
| P141-KN | 101Bio | - | Ask for price |
 Lung Cancer Exosome |
|||
| P141-LG | 101Bio | - | Ask for price |
 Liver Cancer Exosome |
|||
| P141-LV | 101Bio | - | Ask for price |
 Nasopharyngeal Cancer Exosome |
|||
| P141-NA | 101Bio | - | Ask for price |
 Prostate Cancer Exosome |
|||
| P141-PR | 101Bio | - | Ask for price |
 Rheumatoid Arthritis Exosome |
|||
| P141-RA | 101Bio | - | Ask for price |
 Thyroid Cancer Exosome |
|||
| P141-TH | 101Bio | - | Ask for price |
 Psoriasis Exosome RNA |
|||
| P241-PS | 101Bio | - | Ask for price |
 Exosome precipitation Solution |
|||
| EPStep | ImmunoStep | 12 ml | EUR 277.5 |
 Lyophilized Exosome Standards |
|||
| ExoA375 | ImmunoStep | 100 μg | EUR 303.5 |
Lyophilized Exosome Standards |
|||
| ExoHT29 | ImmunoStep | 100 μg | EUR 303.5 |
Lyophilized Exosome Standards |
|||
| ExoMCF7 | ImmunoStep | 100 μg | EUR 303.5 |
Lyophilized Exosome Standards |
|||
| ExoPC3 | ImmunoStep | 100 μg | EUR 303.5 |
Lyophilized Exosome Standards |
|||
| ExoPLASMA | ImmunoStep | 100 μg | EUR 303.5 |
Lyophilized Exosome Standards |
|||
| ExoUrine | ImmunoStep | 100 μg | EUR 303.5 |
) Anti-cTnI McAb (labeling) |
|||
| E63C00404 | EnoGene | 100ug | EUR 382 |
) Anti-PCT McAb (labeling) |
|||
| E63C00904 | EnoGene | 100ug | EUR 382 |
) Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS) |
|||
| P101NGS | 101Bio | - | Ask for price |
Mix-n-Stain CF350 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92230 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405S Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92231 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405M Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92232 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF488A Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92233 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF555 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92234 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF568 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92235 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF594 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92236 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF633 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92237 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF647 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92238 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660C Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92239 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF680 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92240 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF750 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92241 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF770 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92242 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660R Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92243 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF640R Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92245 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF680R Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92246 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF543 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92247 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF790 Antibody Labeling Kit, 1x(50-100ug) labeling |
|||
| 92248 | Biotium | 1KIT | EUR 185 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF350 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92250 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405S Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92251 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405M Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92252 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF488A Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92253 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF555 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92254 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF568 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92255 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF594 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92256 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF633 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92257 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF640R Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92258 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF647 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92259 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660C Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92260 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660R Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92261 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF680 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92262 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF680R Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92263 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF750 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92264 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF770 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92265 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF543 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92267 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF790 Antibody Labeling Kit, 1x(20-50ug) labeling |
|||
| 92268 | Biotium | 1KIT | EUR 172 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF350 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92270 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405S Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92271 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF405M Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92272 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF488A Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92273 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF555 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92274 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF568 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92275 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF594 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92276 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF633 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92277 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF640R Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92278 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF647 Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92279 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660C Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92280 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||
Mix-n-Stain CF660R Antibody Labeling Kit, 1x(5-20ug) labeling |
|||
| 92281 | Biotium | 1KIT | EUR 161 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
|||