exosomes promote restoration from traumatic mind damage by way of microglia

ataxin

Mechanical stress promotes angiogenesis by means of fibroblast exosomes

 

Background: Mechanical stress can induce a number of purposeful modifications in vascular endothelial cells, together with proliferation, differentiation, and migration. Moreover, human fibroblasts are inclined to exterior mechanical stress. On this work, we investigated whether or not mechanical stress can induce exosome secretion from fibroblasts to modulate angiogenesis.

 

Strategies: A CCK-Eight cell proliferation assay was used to find out mechanical parameters. Then, exosomes from fibroblasts had been remoted and characterised with regard to focus and markers. We subsequently explored the impact of exosomes on proliferation, migration, and angiogenesis. Moreover, high-throughput sequencing was used to display screen differentially expressed miRNAs within the mechanical stress-induced exosomes.

 

Outcomes: A static stretching of 15% considerably enhanced the cell viability of the fibroblasts (p < 0.05) and considerably induced the secretion of exosomes from the fibroblasts, which had a stronger internalization capacity. Additional experiments demonstrated that the presence of static stretching-induced exosomes considerably elevated cell proliferation, migration, and angiogenesis by regulating the Erk1/2 signaling pathway. Moreover, 12 up-regulated and 12 down-regulated candidate miRNAs had been discriminated within the static stretching-induced exosomes.

 

Conclusion: Our findings conclusively exhibit that static stretching-derived exosomes from fibroblasts promote angiogenesis by means of differentially expressed miRNAs, offering novel insights into the molecular mechanism by which mechanical stress influences angiogenesis.

ataxin

ataxin

EZLabel? Antibody Biotin Labeling Kit

K834-5
EUR 376

EZLabel? Antibody Cy3 Labeling Kit

K836-5
EUR 354

EZLabel? Antibody Cy5 Labeling Kit

K838-5
EUR 354

Mix-n-Stain CF350 Antibody Labeling Kit, 1x(50-100ug) labeling

92230 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405S Antibody Labeling Kit, 1x(50-100ug) labeling

92231 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405M Antibody Labeling Kit, 1x(50-100ug) labeling

92232 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF488A Antibody Labeling Kit, 1x(50-100ug) labeling

92233 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF555 Antibody Labeling Kit, 1x(50-100ug) labeling

92234 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF568 Antibody Labeling Kit, 1x(50-100ug) labeling

92235 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF594 Antibody Labeling Kit, 1x(50-100ug) labeling

92236 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF633 Antibody Labeling Kit, 1x(50-100ug) labeling

92237 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF647 Antibody Labeling Kit, 1x(50-100ug) labeling

92238 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660C Antibody Labeling Kit, 1x(50-100ug) labeling

92239 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680 Antibody Labeling Kit, 1x(50-100ug) labeling

92240 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF750 Antibody Labeling Kit, 1x(50-100ug) labeling

92241 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF770 Antibody Labeling Kit, 1x(50-100ug) labeling

92242 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660R Antibody Labeling Kit, 1x(50-100ug) labeling

92243 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain Biotin Antibody Labeling Kit, 1x(50-100ug) labeling

92244 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF640R Antibody Labeling Kit, 1x(50-100ug) labeling

92245 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680R Antibody Labeling Kit, 1x(50-100ug) labeling

92246 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF543 Antibody Labeling Kit, 1x(50-100ug) labeling

92247 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF790 Antibody Labeling Kit, 1x(50-100ug) labeling

92248 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF350 Antibody Labeling Kit, 1x(20-50ug) labeling

92250 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405S Antibody Labeling Kit, 1x(20-50ug) labeling

92251 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405M Antibody Labeling Kit, 1x(20-50ug) labeling

92252 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF488A Antibody Labeling Kit, 1x(20-50ug) labeling

92253 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF555 Antibody Labeling Kit, 1x(20-50ug) labeling

92254 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF568 Antibody Labeling Kit, 1x(20-50ug) labeling

92255 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF594 Antibody Labeling Kit, 1x(20-50ug) labeling

92256 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF633 Antibody Labeling Kit, 1x(20-50ug) labeling

92257 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF640R Antibody Labeling Kit, 1x(20-50ug) labeling

92258 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF647 Antibody Labeling Kit, 1x(20-50ug) labeling

92259 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660C Antibody Labeling Kit, 1x(20-50ug) labeling

92260 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660R Antibody Labeling Kit, 1x(20-50ug) labeling

92261 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680 Antibody Labeling Kit, 1x(20-50ug) labeling

92262 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680R Antibody Labeling Kit, 1x(20-50ug) labeling

92263 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF750 Antibody Labeling Kit, 1x(20-50ug) labeling

92264 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF770 Antibody Labeling Kit, 1x(20-50ug) labeling

92265 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain Biotin Antibody Labeling Kit, 1x(20-50ug) labeling

92266 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF543 Antibody Labeling Kit, 1x(20-50ug) labeling

92267 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF790 Antibody Labeling Kit, 1x(20-50ug) labeling

92268 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF350 Antibody Labeling Kit, 1x(5-20ug) labeling

92270 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405S Antibody Labeling Kit, 1x(5-20ug) labeling

92271 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405M Antibody Labeling Kit, 1x(5-20ug) labeling

92272 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF488A Antibody Labeling Kit, 1x(5-20ug) labeling

92273 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF555 Antibody Labeling Kit, 1x(5-20ug) labeling

92274 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF568 Antibody Labeling Kit, 1x(5-20ug) labeling

92275 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF594 Antibody Labeling Kit, 1x(5-20ug) labeling

92276 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF633 Antibody Labeling Kit, 1x(5-20ug) labeling

92277 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF640R Antibody Labeling Kit, 1x(5-20ug) labeling

92278 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF647 Antibody Labeling Kit, 1x(5-20ug) labeling

92279 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660C Antibody Labeling Kit, 1x(5-20ug) labeling

92280 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660R Antibody Labeling Kit, 1x(5-20ug) labeling

92281 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680 Antibody Labeling Kit, 1x(5-20ug) labeling

92282 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680R Antibody Labeling Kit, 1x(5-20ug) labeling

92283 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF750 Antibody Labeling Kit, 1x(5-20ug) labeling

92284 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF770 Antibody Labeling Kit, 1x(5-20ug) labeling

92285 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain Biotin Antibody Labeling Kit, 1x(5-20ug) labeling

92286 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF543 Antibody Labeling Kit, 1x(5-20ug) labeling

92287 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF790 Antibody Labeling Kit, 1x(5-20ug) labeling

92288 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF532 Antibody Labeling Kit, 1x(5-20ug) labeling

92289 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF532 Antibody Labeling Kit, 1x(20-50ug) labeling

92290 1Kit
EUR 172
Description: Minimum order quantity: 1 unit of 1Kit

Mix-n-Stain CF532 Antibody Labeling Kit, 1x(50-100ug) labeling

92291 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain FITC Antibody Labeling Kit, 1x(5-20ug) labeling

92294 1KIT
EUR 120
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain FITC Antibody Labeling Kit, 1x(20-50ug) labeling

92295 1KIT
EUR 132
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain FITC Antibody Labeling Kit, 1x(50-100ug) labeling

92296 1KIT
EUR 143
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain RPE Antibody Labeling Kit, 1x(5-20ug) labeling

92297 1KIT
EUR 166
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain RPE Antibody Labeling Kit, 1x(25-50ug) labeling

92298 1KIT
EUR 177
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain RPE Antibody Labeling Kit, 1x(50-100ug) labeling

92299 1KIT
EUR 189
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain HRP Antibody Labeling Kit, 1x(10-20ug) labeling

92300 1KIT
EUR 155
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain HRP Antibody Labeling Kit, 1x(25-50ug) labeling

92301 1KIT
EUR 166
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain HRP Antibody Labeling Kit, 1x(50-100ug) labeling

92302 1KIT
EUR 177
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405L Antibody Labeling Kit, 1x(5-20ug) labeling

92303 1KIT
EUR 161
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405L Antibody Labeling Kit, 1x(20-50ug) labeling

92304 1Kit
EUR 172
Description: Minimum order quantity: 1 unit of 1Kit

Mix-n-Stain CF405L Antibody Labeling Kit, 1x(50-100ug) labeling

92305 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain APC Antibody Labeling Kit, 1x(25-50ug) labeling

92306 1KIT
EUR 177
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain APC Antibody Labeling Kit, 1x(50-100ug) labeling

92307 1KIT
EUR 189
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain PerCP Antibody Labeling Kit, 1x(25-50ug) labeling

92308 1KIT
EUR 177
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain PerCP Antibody Labeling Kit, 1x(50-100ug) labeling

92309 1KIT
EUR 189
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF430 Antibody Labeling Kit, 1x(5-20ug) labeling

92316 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF430 Antibody Labeling Kit, 1x(20-50ug) labeling

92317 1Kit
EUR 195
Description: Minimum order quantity: 1 unit of 1Kit

Mix-n-Stain CF430 Antibody Labeling Kit, 1x(50-100ug) labeling

92318 1KIT
EUR 207
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF440 Antibody Labeling Kit, 1x(5-20ug) labeling

92319 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF440 Antibody Labeling Kit, 1x(20-50ug) labeling

92320 1Kit
EUR 195
Description: Minimum order quantity: 1 unit of 1Kit

Mix-n-Stain CF440 Antibody Labeling Kit, 1x(50-100ug) labeling

92321 1KIT
EUR 207
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF450 Antibody Labeling Kit, 1x(5-20ug) labeling

92322 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF450 Antibody Labeling Kit, 1x(20-50ug) labeling

92323 1Kit
EUR 195
Description: Minimum order quantity: 1 unit of 1Kit

Mix-n-Stain CF450 Antibody Labeling Kit, 1x(50-100ug) labeling

92324 1KIT
EUR 207
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain DNP Antibody Labeling Kit, 1x(5-20ug) labeling

92325 1KIT
EUR 172
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain DNP Antibody Labeling Kit, 1x(20-50ug) labeling

92326 1Kit
EUR 185
Description: Minimum order quantity: 1 unit of 1Kit

MSC-derived exosomes promote restoration from traumatic mind damage by way of microglia/macrophages in rat

 

Traumatic mind damage (TBI) is a number one reason behind morbidity and mortality in younger people worldwide. There may be presently no efficient scientific therapy for TBI, however mesenchymal stem cell-derived exosomes have exhibited promising therapeutic results.

On this examine, we carried out intracerebroventricular microinjection of human adipose mesenchymal stem cell (hADSC)-derived exosomes (hADSC-ex) in a weight-drop-induced TBI rat mannequin. We discovered that hADSC-ex promoted purposeful restoration, suppressed neuroinflammation, lowered neuronal apoptosis, and elevated neurogenesis in TBI rats.

The therapeutic results of hADSC-ex had been akin to these of hADSC. Sequential in vivo imaging revealed growing aggregation of DiR-labeled hADSC-ex within the lesion space. Immunofluorescent staining of coronal mind sections and first combined neural cell cultures revealed distinct overlap between CM-DiI-labeled hADSC-ex and microglia/macrophages, indicating that hADSC-ex had been primarily taken up by microglia/macrophages.

In a lipopolysaccharide-induced inflammatory mannequin, hADSC-ex suppressed microglia/macrophage activation by inhibiting nuclear issue κB and P38 mitogen-activated protein kinase signaling. These information counsel that hADSC-ex particularly enter microglia/macrophages and suppress their activation throughout mind damage, thereby inhibiting irritation and facilitating purposeful restoration.

In addition they supply new perception into the mobile concentrating on, uptake and migration of hADSC-ex, and supply a theoretical foundation for brand spanking new therapeutic methods for central nervous system ailments.

The Position of Exosomes in Stemness and Neurodegenerative Ailments-Chemoresistant-Most cancers Therapeutics and Phytochemicals

 

  • Exosomes exhibit a variety of organic properties and features within the residing organisms. They’re nanometric automobiles and used for delivering medication, as they’re biocompatible and minimally immunogenic. Exosomal secretions derived from most cancers cells contribute to metastasis, immortality, angiogenesis, tissue invasion, stemness and chemo/radio-resistance.

 

  • Exosome-derived microRNAs (miRNAs) and lengthy non-coding RNAs (lnc RNAs) are concerned within the pathophysiology of cancers and neurodegenerative ailments. As an illustration, exosomes derived from mesenchymal stromal cells, astrocytes, macrophages, and acute myeloid leukemia (AML) cells are concerned within the most cancers development and stemness as they induce chemotherapeutic drug resistance in a number of most cancers cells.

 

  • This evaluation lined the current analysis advances in understanding the position of exosomes in most cancers development, metastasis, angiogenesis, stemness and drug resistance by illustrating the modulatory results of exosomal cargo (ex. miRNA, lncRNAs, and so on.) on cell signaling pathways concerned in most cancers development and most cancers stem cell progress and growth. Current stories have implicated exosomes even within the therapy of a number of cancers.

 

  • As an illustration, exosomes-loaded with novel anti-cancer medication reminiscent of phytochemicals, tumor-targeting proteins, anticancer peptides, nucleic acids are identified to intrude with drug resistance pathways in a number of most cancers cell traces. As well as, this evaluation depicted the necessity to develop exosome-based novel diagnostic biomarkers for early detection of cancers and neurodegenerative illness.

 

  • Moreover, the position of exosomes in stroke and oxidative stress-mediated neurodegenerative ailments together with Alzheimer’s illness (AD), and Parkinson’s illness (PD) can also be mentioned on this article..

 

ACE2 Antibody (biotin)

3217-biotin-01mg 0.1 mg
EUR 495.22
Description: ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Exosome Component 8 (EXOSC8) Antibody (Biotin)

20-abx310196
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exosome Component 5 (EXOSC5) Antibody (Biotin)

20-abx311413
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exosome Component 3 (EXOSC3) Antibody (Biotin)

20-abx312072
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exosome Component 1 (EXOSC1) Antibody (Biotin)

20-abx312488
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exosome Component 10 (EXOSC10) Antibody (Biotin)

20-abx335642
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-human CD14 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00137-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD14 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD11b Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00144-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD11b Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD19 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00154-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD19 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD38 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00193-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD38 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD25 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00214-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD25 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD4 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00344-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD4 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD5 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00480-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD5 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD45 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00555-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD45 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD2 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00570-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD2 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD71 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00591-Biotin 100µg
EUR 245
Description: Mouse Monoclonal human CD71 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD62L Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00652-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD62L Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD59 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00914-Biotin 100µg
EUR 265
Description: Mouse Monoclonal human CD59 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD117 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01335-Biotin 100μg
EUR 224
Description: Mouse Monoclonal human CD117 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD32 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01450-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD32 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD90 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01818-Biotin 100µg
EUR 268
Description: Mouse Monoclonal human CD90 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD7 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01974-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD7 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD235a Monoclonal Antibody Biotin Conjugated, Flow Validated

FC02184-Biotin 100µg
EUR 245
Description: Mouse Monoclonal human CD235a Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD8 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC02236-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD8 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human VEGI Monoclonal Antibody Biotin Conjugated, Flow Validated

FC02402-Biotin Various Sizes
EUR 497
Description: Mouse Monoclonal Human VEGI Antibody Biotin Conjugated, Flow Validated. Validated in WB and tested in Human.

Anti-human CD3 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC02675-Biotin 100µg
EUR 152
Description: Mouse Monoclonal human CD3 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD20 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC03780-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD20 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD10 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC04065-Biotin 100µg
EUR 189
Description: Mouse Monoclonal human CD10 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD57 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC09548-Biotin 100µg
EUR 245
Description: Mouse Monoclonal human CD57 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human HLA-DR Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00568-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human HLA-DR Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD55/Daf Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00910-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD55/Daf Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

PD1 Antibody [7H6] (biotin)

RF16003-biotin-002mg 0.02 mg
EUR 191.42
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

PD1 Antibody [7H6] (biotin)

RF16003-biotin-01mg 0.1 mg
EUR 495.22
Description: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

PDL1 Antibody [8E12] (biotin)

RF16032-biotin-002mg 0.02 mg
EUR 191.42
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).

PDL1 Antibody [8E12] (biotin)

RF16032-biotin-01mg 0.1 mg
EUR 495.22
Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).

TIGIT Antibody [10B1] (biotin)

RF16058-biotin-002mg 0.02 mg
EUR 191.42
Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

TIGIT Antibody [10B1] (biotin)

RF16058-biotin-01mg 0.1 mg
EUR 495.22
Description: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

TIM3 Antibody [10C10] (biotin)

RF16103-biotin-002mg 0.02 mg
EUR 191.42
Description: The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

TIM3 Antibody [10C10] (biotin)

RF16103-biotin-01mg 0.1 mg
EUR 495.22
Description: The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01508-Biotin 100µg
EUR 234
Description: Mouse Monoclonal human CD33/Siglec 3 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD22/Siglec 2 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01572-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human CD22/Siglec 2 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Exosome complex exonuclease DIS3 (DIS3) Antibody (Biotin)

20-abx335639
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Labeling Tape, Blue

TP001B 1ROLLS, 1 UNIT
EUR 53.68

Labeling Tape, Red

TP002R 1ROLLS, 1 UNIT
EUR 53.68

Labeling Tape, White

TP003W 1ROLLS, 1 UNIT
EUR 53.68

Labeling Tape, Yellow

TP004Y 1ROLLS, 1 UNIT
EUR 53.68

SARS-CoV-2 (COVID-19) Spike Antibody (biotin)

3525-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike Antibody (biotin)

3525-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Envelope Antibody (biotin)

3531-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one alpha-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication (3).

SARS-CoV-2 (COVID-19) Envelope Antibody (biotin)

3531-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Envelope protein is a small polypeptide that contains at least one alpha-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication (3).

SARS-CoV-2 (COVID-19) Nucleocapsid Antibody (biotin)

9099-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2). Nucleocapsid (N) protein is the most abundant protein of coronavirus. It is also one of the major structural proteins and is involved in the transcription and replication of viral RNA, packaging of the encapsidated genome into virions (3), and interference with cell cycle processes of host cells (4). Moreover, in many coronaviruses, including SARS-CoV, the N protein has high immunogenic activity and is abundantly expressed during infection (5). It can be detected in various patient samples including nasopharyngeal aspirate, urine, and fecal. Both S and N proteins may be potential antigens for serodiagnosis of COVID-19, just as many diagnostic methods have been developed for diagnosing SARS based on S and/or N proteins (6).

SARS-CoV-2 (COVID-19) Nucleocapsid Antibody (biotin)

9099-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2). Nucleocapsid (N) protein is the most abundant protein of coronavirus. It is also one of the major structural proteins and is involved in the transcription and replication of viral RNA, packaging of the encapsidated genome into virions (3), and interference with cell cycle processes of host cells (4). Moreover, in many coronaviruses, including SARS-CoV, the N protein has high immunogenic activity and is abundantly expressed during infection (5). It can be detected in various patient samples including nasopharyngeal aspirate, urine, and fecal. Both S and N proteins may be potential antigens for serodiagnosis of COVID-19, just as many diagnostic methods have been developed for diagnosing SARS based on S and/or N proteins (6).

SARS-CoV-2 (COVID-19) Nucleocapsid Antibody (biotin)

9103-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2). Nucleocapsid (N) protein is the most abundant protein of coronavirus. It is also one of the major structural proteins and is involved in the transcription and replication of viral RNA, packaging of the encapsidated genome into virions (3), and interference with cell cycle processes of host cells (4). Moreover, in many coronaviruses, including SARS-CoV, the N protein has high immunogenic activity and is abundantly expressed during infection (5). It can be detected in various patient samples including nasopharyngeal aspirate, urine, and fecal. Both S and N proteins may be potential antigens for serodiagnosis of COVID-19, just as many diagnostic methods have been developed for diagnosing SARS based on S and/or N proteins (6).

SARS-CoV-2 (COVID-19) Nucleocapsid Antibody (biotin)

9103-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2). Nucleocapsid (N) protein is the most abundant protein of coronavirus. It is also one of the major structural proteins and is involved in the transcription and replication of viral RNA, packaging of the encapsidated genome into virions (3), and interference with cell cycle processes of host cells (4). Moreover, in many coronaviruses, including SARS-CoV, the N protein has high immunogenic activity and is abundantly expressed during infection (5). It can be detected in various patient samples including nasopharyngeal aspirate, urine, and fecal. Both S and N proteins may be potential antigens for serodiagnosis of COVID-19, just as many diagnostic methods have been developed for diagnosing SARS based on S and/or N proteins (6).

SARS-CoV-2 (COVID-19) Membrane Antibody (biotin)

9157-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2).The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

SARS-CoV-2 (COVID-19) Membrane Antibody (biotin)

9157-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2).The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).

Psoriasis Exosome

P141-PS - Ask for price

SARS-CoV-2 (COVID-19) Spike S1 Antibody (biotin)

9083-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike S1 Antibody (biotin)

9083-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike RBD Antibody (biotin)

9087-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike RBD Antibody (biotin)

9087-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike 681P Antibody (biotin)

9091-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike 681P Antibody (biotin)

9091-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike S2 Antibody (biotin)

9123-biotin-002mg 0.02 mg
EUR 191.42
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

SARS-CoV-2 (COVID-19) Spike S2 Antibody (biotin)

9123-biotin-01mg 0.1 mg
EUR 495.22
Description: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

Mouse anti-human CD7 Monoclonal Antibody Biotin Conjugated, Flow Validated

FC01974-1-Biotin 100µg
EUR 233
Description: Mouse Monoclonal Mouse human CD7 Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

HIV-1 p24 Antibody [8G9] (biotin)

PM-6335-biotin-002mg 0.02 mg
EUR 171.82
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [8G9] (biotin)

PM-6335-biotin-01mg 0.1 mg
EUR 436.42
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)

PM-6585-biotin-002mg 0.02 mg
EUR 171.82
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

HIV-1 p24 Antibody [7F4] (biotin)

PM-6585-biotin-01mg 0.1 mg
EUR 436.42
Description: HIV-1 p24 Monoclonal Antibody: The human immunodeficiency virus type 1 (HIV-1) particle consists of an envelope, a core and the region between the two termed matrix (1). The HIV-1 Gag protein is a late structural protein that contains four proteins: matrix (p17), capsid (p24), nucleocapsid (p7) and the p6 protein (2). The p24 constitutes the major core component of the virus and shows high degree of sequence conservation among HIV isolates. The Gag p24 has been used as an integral part of multicomponent HIV-1 vaccines (3).

Anti-cTnI McAb (labeling)

E63C00404 100ug
EUR 382

Anti-PCT McAb (labeling)

E63C00904 100ug
EUR 382

Leukemia - ALL Exosome

P141-ALL - Ask for price

Leukemia - AML Exosome

P141-AML - Ask for price

Bladder Cancer Exosome

P141-BL - Ask for price

Breast Cancer Exosome

P141-BR - Ask for price

Leukemia - CLL Exosome

P141-CLL - Ask for price

Leukemia - CML Exosome

P141-CML - Ask for price

Colorectal Cancer Exosome

P141-CO - Ask for price

Crohn's Disease Exosome

P141-CR - Ask for price

Kidney Cancer Exosome

P141-KN - Ask for price

Lung Cancer Exosome

P141-LG - Ask for price

Liver Cancer Exosome

P141-LV - Ask for price

Nasopharyngeal Cancer Exosome

P141-NA - Ask for price

Prostate Cancer Exosome

P141-PR - Ask for price

Rheumatoid Arthritis Exosome

P141-RA - Ask for price

Thyroid Cancer Exosome

P141-TH - Ask for price

Psoriasis Exosome RNA

P241-PS - Ask for price

Lyophilized Exosome Standards

ExoA375 100 μg
EUR 303.5

Lyophilized Exosome Standards

ExoHT29 100 μg
EUR 303.5

Lyophilized Exosome Standards

ExoMCF7 100 μg
EUR 303.5

Lyophilized Exosome Standards

ExoPC3 100 μg
EUR 303.5

Lyophilized Exosome Standards

ExoPLASMA 100 μg
EUR 303.5

Lyophilized Exosome Standards

ExoUrine 100 μg
EUR 303.5

Exosome precipitation Solution

EPStep 12 ml
EUR 277.5

Mix-n-Stain CF350 Antibody Labeling Kit, 1x(50-100ug) labeling

92230 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405S Antibody Labeling Kit, 1x(50-100ug) labeling

92231 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF405M Antibody Labeling Kit, 1x(50-100ug) labeling

92232 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF488A Antibody Labeling Kit, 1x(50-100ug) labeling

92233 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF555 Antibody Labeling Kit, 1x(50-100ug) labeling

92234 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF568 Antibody Labeling Kit, 1x(50-100ug) labeling

92235 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF594 Antibody Labeling Kit, 1x(50-100ug) labeling

92236 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF633 Antibody Labeling Kit, 1x(50-100ug) labeling

92237 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF647 Antibody Labeling Kit, 1x(50-100ug) labeling

92238 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660C Antibody Labeling Kit, 1x(50-100ug) labeling

92239 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF680 Antibody Labeling Kit, 1x(50-100ug) labeling

92240 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF750 Antibody Labeling Kit, 1x(50-100ug) labeling

92241 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF770 Antibody Labeling Kit, 1x(50-100ug) labeling

92242 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF660R Antibody Labeling Kit, 1x(50-100ug) labeling

92243 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

Mix-n-Stain CF640R Antibody Labeling Kit, 1x(50-100ug) labeling

92245 1KIT
EUR 185
Description: Minimum order quantity: 1 unit of 1KIT

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