In view of upcoming scientific trials, quantitative molecular markers accessible in peripheral blood are of important significance as prognostic or pharmacodynamic markers in genetic neurodegenerative ailments comparable to Spinocerebellar Ataxia Kind 3 (SCA3), specifically for signaling goal engagement. On this pilot examine, we centered on the quantification of ataxin-3, the protein altered in SCA3, in human peripheral blood mononuclear cells (PBMCs) acquired from preataxic and ataxic SCA3 mutation carriers in addition to wholesome controls, as a molecular marker immediately associated to SCA3 pathophysiology.
We established two completely different extremely delicate TR-FRET-based immunoassays to measure the protein ranges of both complete full-length, non-expanded and expanded, ataxin-Three or particularly polyQ-expanded ataxin-3. In PBMCs, a transparent discrimination between SCA3 mutation service and controls had been seen measuring polyQ-expanded ataxin-Three protein stage. Moreover, polyQ-expanded ataxin-Three protein ranges correlated with illness development and scientific severity as assessed by the Scale for the Evaluation and Score of Ataxia. Complete full-length ataxin-Three protein ranges had been immediately influenced by the expression ranges of the polyQ-expanded ataxin-Three protein, however weren’t correlated with scientific parameters. Evaluation of ataxin-Three ranges in fibroblasts or induced pluripotent stem cells allowed to differentiate mutation carriers from controls, thus offering proof-of-principle validation of our PBMC findings throughout cell traces.
Complete full-length or polyQ-expanded ataxin-Three protein was not detectable by TR-FRET assays in different biofluids like plasma or cerebrospinal fluid, indicating the necessity for ultra-sensitive assays for these biofluids. Standardization research revealed that tube techniques, blood sampling, and PBMC preparation could affect ataxin-Three protein ranges indicating a excessive demand for standardized protocols in biomarker research. In conclusion, the polyQ-expanded ataxin-Three protein is a promising candidate as a molecular goal engagement marker in SCA3 in future scientific trials, determinable even in-easily accessible-peripheral blood biomaterials. These outcomes, nevertheless, require validation in a bigger cohort and additional standardization of modifying situations.
Capturing the Conformational Ensemble of the Blended Folded Polyglutamine Protein Ataxin-3
Ataxin-Three is a deubiquitinase concerned in protein high quality management and different important mobile capabilities. It preferentially interacts with polyubiquitin chains of 4 or extra items hooked up to proteins delivered to the ubiquitin-proteasome system. Ataxin-Three consists of an N-terminal Josephin area and a versatile C terminus that comprises two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine tract, which, when expanded past a threshold, results in protein aggregation and misfolding and causes spinocerebellar ataxia kind 3. The high-resolution construction of the Josephin area is offered, however the structural and dynamical heterogeneity of ataxin-Three has to this point hindered the structural description of the full-length protein.
Right here, we characterize non-expanded and expanded variants of ataxin-Three by way of conformational ensembles adopted by the proteins in resolution by collectively utilizing experimental knowledge from nuclear magnetic resonance and small-angle X-ray scattering with coarse-grained simulations. Our outcomes pave the best way to a molecular understanding of polyubiquitin recognition. Right here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human organic fluids and discriminates sufferers with SCA3 from wholesome controls and people with different ataxias. We present that polyQ ATXN3 serves as a marker of goal engagement in human fibroblasts, which can bode properly for its use in scientific trials.
Final, we recognized a single-nucleotide polymorphism that strongly associates with the expanded allele, thus offering an thrilling drug goal to abrogate detrimental occasions initiated by mutant ATXN3. Gene-silencing methods for a number of repeat ailments are properly underneath method, and our outcomes are anticipated to enhance scientific trial preparedness for SCA3 therapies.
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study
Dynamics of a Protein Interplay Community Related to the Aggregation of polyQ-Expanded Ataxin-1
Background: A number of experimental fashions of polyglutamine (polyQ) ailments have been beforehand developed which can be helpful for learning illness development within the primarily affected central nervous system. Nevertheless, there’s a lacking hyperlink between mobile and animal fashions that may point out the molecular defects occurring in neurons and are chargeable for the illness phenotype in vivo.
Strategies: Right here, we used a computational method to establish dysregulated pathways shared by an in vitro and an in vivo mannequin of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ illness spinocerebellar ataxia type-1 (SCA1).
Outcomes: A set of widespread dysregulated pathways had been recognized, which had been utilized to assemble cerebellum-specific protein-protein interplay (PPI) networks at numerous time-points of protein aggregation. Evaluation of a SCA1 community indicated essential nodes which regulate its perform and may characterize potential pharmacological targets. Moreover, a set of medicine interacting with these nodes and predicted to enter the blood-brain barrier (BBB) was recognized.
Rabbit Polyclonal antibody to Ataxin 3 (ataxin 3) |
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| TA308320 | Origene Technologies GmbH | 100 µl | Ask for price |
Ataxin-3 Protein |
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| abx262861-10mg | Abbexa | 10 mg | EUR 325 |
Ataxin-3 Protein |
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| 20-abx262861 | Abbexa |
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Ataxin-3 Protein |
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| abx262861-25mg | Abbexa | 25 mg | EUR 6575 |
Ataxin-3 Protein |
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| abx262861-5mg | Abbexa | 5 mg | EUR 225 |
Ataxin 3 protein |
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| 30R-1344 | Fitzgerald | 50 ug | EUR 307 |
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Description: Purified recombinant Human Ataxin 3 protein |
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Ataxin 3 antibody |
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| 22437 | SAB | 100ul | EUR 479 |
Ataxin 3 antibody |
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| 22437-100ul | SAB | 100ul | EUR 468 |
Ataxin 3 antibody |
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| 70R-13630 | Fitzgerald | 100 ul | EUR 548 |
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Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody |
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Ataxin 3 Antibody |
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| E300595 | EnoGene | 100ug/200ul | EUR 275 |
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Description: Available in various conjugation types. |
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Ataxin 3 Antibody |
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| DF6375 | Affbiotech | 200ul | EUR 420 |
Ataxin 3 Antibody |
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| DF6375-100ul | Affinity Biosciences | 100ul | EUR 168 |
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Description: WB,IHC,ELISA(peptide) |
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Ataxin 3 Antibody |
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| DF6375-200ul | Affinity Biosciences | 200ul | EUR 210 |
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Description: WB,IHC,ELISA(peptide) |
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Ataxin 3 Antibody |
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| MBS5312481-01mL | MyBiosource | 0.1mL | EUR 1065 |
Ataxin 3 Antibody |
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| MBS5312481-5x01mL | MyBiosource | 5x0.1mL | EUR 4640 |
Ataxin 3 Antibody |
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| MBS853397-01mg | MyBiosource | 0.1mg | EUR 345 |
Ataxin 3 Antibody |
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| MBS853397-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Ataxin 3 Antibody |
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| MBS853397-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Ataxin 3 Antibody |
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| MBS853397-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Ataxin 3 Antibody |
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| MBS853397-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Ataxin 3 antibody |
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| MBS9404933-01mL | MyBiosource | 0.1mL | EUR 420 |
Ataxin 3 antibody |
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| MBS9404933-5x01mL | MyBiosource | 5x0.1mL | EUR 1740 |
Ataxin-3 (pS256) Antibody |
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| abx148457-100ug | Abbexa | 100 ug | EUR 526.8 |
Recombinant Human Ataxin-3 |
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| 7-04462 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04463 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04464 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Ataxin-3 |
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| MBS143572-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Human Ataxin-3 |
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| MBS143572-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Human Ataxin-3 |
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| MBS143572-1mg | MyBiosource | 1mg | EUR 5345 |
Recombinant Human Ataxin-3 |
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| MBS143572-5x1mg | MyBiosource | 5x1mg | EUR 23725 |
Ataxin-3 Human Recombinant |
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| rAP-4434 | Angio Proteomie | Inquiry | Ask for price |
Ataxin 3 Rabbit pAb |
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| A1243-200ul | Abclonal | 200 ul | EUR 550.8 |
Ataxin 3 Rabbit pAb |
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| A1243-20ul | Abclonal | 20 ul | EUR 219.6 |
Ataxin 3 Rabbit pAb |
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| A12992-100ul | Abclonal | 100 ul | EUR 369.6 |
Ataxin 3 Rabbit pAb |
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| A12992-200ul | Abclonal | 200 ul | EUR 550.8 |
Ataxin 3 Rabbit pAb |
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| A12992-20ul | Abclonal | 20 ul | EUR 219.6 |
Ataxin 3 Rabbit pAb |
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| A12992-50ul | Abclonal | 50 ul | EUR 267.6 |
Ataxin 3 Rabbit mAb |
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| E2R26443 | EnoGene | 100ul | EUR 255 |
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Description: Available in various conjugation types. |
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Ataxin 3 Rabbit pAb |
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| E45R19058N | EnoGene | 50 ul | EUR 297.75 |
Ataxin 3 Rabbit pAb |
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| E45R19588N | EnoGene | 50 ul | EUR 297.75 |
Ataxin 3 Rabbit mAb |
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| MBS4753194-01mL | MyBiosource | 0.1mL | EUR 450 |
Ataxin 3 Rabbit mAb |
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| MBS4753194-5x01mL | MyBiosource | 5x0.1mL | EUR 1540 |
Ataxin 3 Rabbit mAb |
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| MBS9467429-005mL | MyBiosource | 0.05mL | EUR 290 |
Ataxin 3 Rabbit mAb |
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| MBS9467429-01mL | MyBiosource | 0.1mL | EUR 435 |
Ataxin 3 Rabbit mAb |
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| MBS9467429-5x01mL | MyBiosource | 5x0.1mL | EUR 1810 |
Ataxin-3 (ATXN3) Rabbit pAb |
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| A1243 | Abclonal | 200μL | EUR 173.58 |
Ataxin-3 (ATXN3) Rabbit pAb |
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| A12992 | Abclonal | 500μL | EUR 88.56 |
Ataxin-3 (ATXN3) Rabbit mAb |
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| A22094 | Abclonal | 100μL | EUR 343.62 |
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Description: A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036). |
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Ataxin-10 |
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| AP80722 | SAB | 1mg | EUR 2640 |
Ataxin-10 |
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| AP80782 | SAB | 1mg | EUR 2640 |
Ataxin-10 |
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| AP81057 | SAB | 1mg | EUR 2640 |
Ataxin-10 |
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| AP81093 | SAB | 1mg | EUR 2640 |
Ataxin 3 Blocking Peptide |
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| MBS9625749-1mg | MyBiosource | 1mg | EUR 380 |
Ataxin 3 Blocking Peptide |
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| MBS9625749-5x1mg | MyBiosource | 5x1mg | EUR 1650 |
Recombinant Ataxin 3 (ATXN3) |
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| RPD250Hu01 | Cloud-Clone | 10ug | EUR 120 |
Ataxin 3 Polyclonal Antibody |
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| 27857-100ul | SAB | 100ul | EUR 302.4 |
Ataxin 3 Polyclonal Antibody |
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| 27857-50ul | SAB | 50ul | EUR 224.4 |
Ataxin 3 Polyclonal Antibody |
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| A70452 | EpiGentek |
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Ataxin 3 Polyclonal Antibody |
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| E-AB-60279-120uL | Elabscience Biotech | 120uL | EUR 320 |
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Description: Unconjugated |
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Ataxin 3 Polyclonal Antibody |
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| E-AB-60279-200uL | Elabscience Biotech | 200uL | EUR 530 |
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Description: Unconjugated |
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Ataxin 3 Polyclonal Antibody |
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| E-AB-60279-60uL | Elabscience Biotech | 60uL | EUR 200 |
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Description: Unconjugated |
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Ataxin 3 Polyclonal Antibody |
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| E-AB-60279-each | Elabscience Biotech | each | Ask for price |
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Description: Unconjugated |
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Ataxin 3 monoclonal antibody |
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| MB11923 | Bioworld Biotech | 50ul | EUR 398 |
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Description: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
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Ataxin 3 Polyclonal Antibody |
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| MBS9236179-01mL | MyBiosource | 0.1mL | EUR 415 |
Ataxin 3 Polyclonal Antibody |
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| MBS9236179-5x01mL | MyBiosource | 5x0.1mL | EUR 1841 |
Ataxin 3 Polyclonal Antibody |
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| RD80919A-120uL | Reddot Biotech | 120μL | EUR 360 |
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Description: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
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Ataxin 3 Polyclonal Antibody |
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| RD80919A-200uL | Reddot Biotech | 200μL | EUR 630 |
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Description: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
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Ataxin 3 Polyclonal Antibody |
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| RD80919A-60uL | Reddot Biotech | 60μL | EUR 204 |
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Description: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
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Ataxin-3 Fluorescent Assay Kit |
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| 78044 | BPS Bioscience | 96 rxns. | EUR 765 |
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Description: The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. |
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Recombinant Rat Ataxin-3 (Atxn3) |
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| MBS1243203-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1230 |
Recombinant Rat Ataxin-3 (Atxn3) |
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| MBS1243203-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 890 |
Recombinant Rat Ataxin-3 (Atxn3) |
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| MBS1243203-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1020 |
Recombinant Rat Ataxin-3 (Atxn3) |
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| MBS1243203-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1070 |
Recombinant Rat Ataxin-3 (Atxn3) |
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| MBS1243203-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1160 |
Recombinant Human Ataxin-3 (ATXN3) |
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| CSB-EP002443HU | Cusabio | 11921 mg | Ask for price |
Recombinant Human Ataxin-3 (ATXN3) |
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| CSB-EP002443HU-100ug | Cusabio | 100ug | Ask for price |
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Description: 1-364aa |
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Recombinant Human Ataxin-3 (ATXN3) |
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| CSB-EP002443HU-1mg | Cusabio | 1mg | Ask for price |
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Description: 1-364aa |
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Recombinant Human Ataxin-3 (ATXN3) |
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| CSB-EP002443HU-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-364aa |
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Recombinant Mouse Ataxin-3 (Atxn3) |
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| MBS1457204-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1230 |
Recombinant Mouse Ataxin-3 (Atxn3) |
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| MBS1457204-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 890 |
Recombinant Mouse Ataxin-3 (Atxn3) |
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| MBS1457204-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1020 |
Recombinant Mouse Ataxin-3 (Atxn3) |
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| MBS1457204-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1070 |
Recombinant Mouse Ataxin-3 (Atxn3) |
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| MBS1457204-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1160 |
Recombinant Human Ataxin-3 (ATXN3) |
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| MBS953525-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1240 |
Recombinant Human Ataxin-3 (ATXN3) |
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| MBS953525-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 900 |
Recombinant Human Ataxin-3 (ATXN3) |
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| MBS953525-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1030 |
Recombinant Human Ataxin-3 (ATXN3) |
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| MBS953525-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1085 |
Recombinant Human Ataxin-3 (ATXN3) |
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| MBS953525-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1170 |
Ataxin 3 (ATXN3) ELISA Kit |
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| MBS2709514-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Ataxin 3 (ATXN3) ELISA Kit |
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| MBS2709514-24StripWells | MyBiosource | 24-Strip-Wells | EUR 255 |
Ataxin 3 (ATXN3) ELISA Kit |
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| MBS2709514-48StripWells | MyBiosource | 48-Strip-Wells | EUR 330 |
Ataxin 3 (ATXN3) ELISA Kit |
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| MBS2709514-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1630 |
Ataxin 3 (ATXN3) ELISA Kit |
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| MBS2709514-96StripWells | MyBiosource | 96-Strip-Wells | EUR 420 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574 | SAB | 100ul | EUR 319 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-100ul | SAB | 100ul | EUR 302.4 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-50ul | SAB | 50ul | EUR 224.4 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| A8293-100ul | Assay Biotech | 100μl | EUR 217 |
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Description: Ataxin-3 (Phospho-Ser256) Rabbit Polyclonal Antibody |
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Ataxin-3 (Phospho-Ser256) Antibody |
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| A8293-50ul | Assay Biotech | 50μl | EUR 143.5 |
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Description: Ataxin-3 (Phospho-Ser256) Rabbit Polyclonal Antibody |
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Ataxin-3 (ATXN3) polyclonal antibody |
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| BS74860 | Bioworld Biotech | 50ul | EUR 358 |
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Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
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Recombinant Chicken Ataxin-3 (ATXN3) |
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| MBS1475975-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1235 |
Recombinant Chicken Ataxin-3 (ATXN3) |
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| MBS1475975-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 900 |
Recombinant Chicken Ataxin-3 (ATXN3) |
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| MBS1475975-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1030 |
Recombinant Chicken Ataxin-3 (ATXN3) |
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| MBS1475975-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1080 |
Recombinant Chicken Ataxin-3 (ATXN3) |
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| MBS1475975-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1170 |
Recombinant Human Ataxin-3 Protein |
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| MBS556290-0002mg | MyBiosource | 0.002mg | EUR 220 |
Recombinant Human Ataxin-3 Protein |
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| MBS556290-001mg | MyBiosource | 0.01mg | EUR 320 |
Recombinant Human Ataxin-3 Protein |
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| MBS556290-5x001mg | MyBiosource | 5x0.01mg | EUR 1300 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| MBS9416662-005mL | MyBiosource | 0.05mL | EUR 245 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| MBS9416662-01mL | MyBiosource | 0.1mL | EUR 305 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| MBS9416662-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
Ataxin 3, 1-370aa, Human, E Coli |
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| MBS203345-001mg | MyBiosource | 0.01mg | EUR 215 |
Ataxin 3, 1-370aa, Human, E Coli |
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| MBS203345-005mg | MyBiosource | 0.05mg | EUR 340 |
Ataxin 3, 1-370aa, Human, E Coli |
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| MBS203345-025mg | MyBiosource | 0.25mg | EUR 765 |
Ataxin 3, 1-370aa, Human, E Coli |
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| MBS203345-5x025mg | MyBiosource | 5x0.25mg | EUR 3195 |
Rat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7212062-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Rat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7212062-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Rat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7212062-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Rat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7212062-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Rat Atxn3 / Ataxin-3 ELISA Kit |
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| E10108r | EIAab | 96T | EUR 796 |
Rat Atxn3/Ataxin-3 ELISA Kit |
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| MBS2903872-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4080 |
Rat Atxn3/Ataxin-3 ELISA Kit |
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| MBS2903872-48StripWells | MyBiosource | 48-Strip-Wells | EUR 390 |
Rat Atxn3/Ataxin-3 ELISA Kit |
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| MBS2903872-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2220 |
Rat Atxn3/Ataxin-3 ELISA Kit |
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| MBS2903872-96StripWells | MyBiosource | 96-Strip-Wells | EUR 520 |
Goat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7238168-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Goat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7238168-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Goat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7238168-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Goat Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7238168-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Sheep Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7237399-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Sheep Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7237399-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Sheep Ataxin-3 (ATXN3) ELISA Kit |
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| MBS7237399-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Sheep Ataxin-3 (ATXN3) ELISA Kit |
|||
| MBS7237399-96StripWells | MyBiosource | 96-Strip-Wells | EUR 690 |
Mouse Ataxin-3 (ATXN3) ELISA Kit |
|||
| MBS7248783-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 5685 |
Mouse Ataxin-3 (ATXN3) ELISA Kit |
|||
| MBS7248783-48StripWells | MyBiosource | 48-Strip-Wells | EUR 485 |
Mouse Ataxin-3 (ATXN3) ELISA Kit |
|||
| MBS7248783-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3020 |
Conclusions: Our examine factors to molecular mechanisms of SCA1 linked from each mobile and animal fashions and suggests medication that could possibly be examined to find out whether or not they have an effect on the aggregation of pathogenic ATXN1 and SCA1 illness development.