PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

In view of upcoming scientific trials, quantitative molecular markers accessible in peripheral blood are of important significance as prognostic or pharmacodynamic markers in genetic neurodegenerative ailments comparable to Spinocerebellar Ataxia Kind 3 (SCA3), specifically for signaling goal engagement. On this pilot examine, we centered on the quantification of ataxin-3, the protein altered in SCA3, in human peripheral blood mononuclear cells (PBMCs) acquired from preataxic and ataxic SCA3 mutation carriers in addition to wholesome controls, as a molecular marker immediately associated to SCA3 pathophysiology.

 

We established two completely different extremely delicate TR-FRET-based immunoassays to measure the protein ranges of both complete full-length, non-expanded and expanded, ataxin-Three or particularly polyQ-expanded ataxin-3. In PBMCs, a transparent discrimination between SCA3 mutation service and controls had been seen measuring polyQ-expanded ataxin-Three protein stage. Moreover, polyQ-expanded ataxin-Three protein ranges correlated with illness development and scientific severity as assessed by the Scale for the Evaluation and Score of Ataxia. Complete full-length ataxin-Three protein ranges had been immediately influenced by the expression ranges of the polyQ-expanded ataxin-Three protein, however weren’t correlated with scientific parameters. Evaluation of ataxin-Three ranges in fibroblasts or induced pluripotent stem cells allowed to differentiate mutation carriers from controls, thus offering proof-of-principle validation of our PBMC findings throughout cell traces.

Complete full-length or polyQ-expanded ataxin-Three protein was not detectable by TR-FRET assays in different biofluids like plasma or cerebrospinal fluid, indicating the necessity for ultra-sensitive assays for these biofluids. Standardization research revealed that tube techniques, blood sampling, and PBMC preparation could affect ataxin-Three protein ranges indicating a excessive demand for standardized protocols in biomarker research. In conclusion, the polyQ-expanded ataxin-Three protein is a promising candidate as a molecular goal engagement marker in SCA3 in future scientific trials, determinable even in-easily accessible-peripheral blood biomaterials. These outcomes, nevertheless, require validation in a bigger cohort and additional standardization of modifying situations.

 

 

Capturing the Conformational Ensemble of the Blended Folded Polyglutamine Protein Ataxin-3

Ataxin-Three is a deubiquitinase concerned in protein high quality management and different important mobile capabilities. It preferentially interacts with polyubiquitin chains of 4 or extra items hooked up to proteins delivered to the ubiquitin-proteasome system. Ataxin-Three consists of an N-terminal Josephin area and a versatile C terminus that comprises two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine tract, which, when expanded past a threshold, results in protein aggregation and misfolding and causes spinocerebellar ataxia kind 3. The high-resolution construction of the Josephin area is offered, however the structural and dynamical heterogeneity of ataxin-Three has to this point hindered the structural description of the full-length protein.
Right here, we characterize non-expanded and expanded variants of ataxin-Three by way of conformational ensembles adopted by the proteins in resolution by collectively utilizing experimental knowledge from nuclear magnetic resonance and small-angle X-ray scattering with coarse-grained simulations. Our outcomes pave the best way to a molecular understanding of polyubiquitin recognition. Right here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human organic fluids and discriminates sufferers with SCA3 from wholesome controls and people with different ataxias. We present that polyQ ATXN3 serves as a marker of goal engagement in human fibroblasts, which can bode properly for its use in scientific trials.
Final, we recognized a single-nucleotide polymorphism that strongly associates with the expanded allele, thus offering an thrilling drug goal to abrogate detrimental occasions initiated by mutant ATXN3. Gene-silencing methods for a number of repeat ailments are properly underneath method, and our outcomes are anticipated to enhance scientific trial preparedness for SCA3 therapies.
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

Dynamics of a Protein Interplay Community Related to the Aggregation of polyQ-Expanded Ataxin-1

Background: A number of experimental fashions of polyglutamine (polyQ) ailments have been beforehand developed which can be helpful for learning illness development within the primarily affected central nervous system. Nevertheless, there’s a lacking hyperlink between mobile and animal fashions that may point out the molecular defects occurring in neurons and are chargeable for the illness phenotype in vivo.
Strategies: Right here, we used a computational method to establish dysregulated pathways shared by an in vitro and an in vivo mannequin of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ illness spinocerebellar ataxia type-1 (SCA1).
Outcomes: A set of widespread dysregulated pathways had been recognized, which had been utilized to assemble cerebellum-specific protein-protein interplay (PPI) networks at numerous time-points of protein aggregation. Evaluation of a SCA1 community indicated essential nodes which regulate its perform and may characterize potential pharmacological targets. Moreover, a set of medicine interacting with these nodes and predicted to enter the blood-brain barrier (BBB) was recognized.

Ataxin 3 protein
30R-1344 50 ug
EUR 366
Description: Purified recombinant Human Ataxin 3 protein

Ataxin 3 antibody
22437-100ul 100ul
EUR 468

Ataxin-3 Protein
20-abx262861
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ataxin 3 Antibody
DF6375 200ul
EUR 420

Recombinant Human Ataxin-3
7-04462 2µg Ask for price

Recombinant Human Ataxin-3
7-04463 10µg Ask for price

Recombinant Human Ataxin-3
7-04464 1mg Ask for price

Ataxin 3 Rabbit pAb
A1243-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb
A1243-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb
A1243-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb
A1243-50ul 50 ul
EUR 267.6

Ataxin 3 Rabbit pAb
A12992-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb
A12992-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb
A12992-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb
A12992-50ul 50 ul
EUR 267.6

Ataxin 3 Polyclonal Antibody
27857-100ul 100ul
EUR 302.4

Ataxin 3 Polyclonal Antibody
27857-50ul 50ul
EUR 224.4

Ataxin-3 (pS256) Antibody
abx148457-100ug 100 ug
EUR 526.8

Ataxin 3 Polyclonal Antibody
A70452
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

Ataxin 3 Polyclonal Antibody
A70452-050 50 ul
EUR 302.5

Ataxin 3 Polyclonal Antibody
A70452-100 100 ul
EUR 423.5

Ataxin 3 Antibody / ATXN3
F55027-0.08ML 0.08 ml
EUR 165

Ataxin 3 Antibody / ATXN3
F55027-0.4ML 0.4 ml
EUR 379

Ataxin 3 Antibody / ATXN3
R32137 100 ug
EUR 419

Recombinant Transmembrane Protease Serine 2 Protein, Partial
E80016
  • EUR 470.80
  • EUR 753.50
  • EUR 1824.90
  • 20 ul
  • 100 ul
  • 500 ul

Recombinant TMPRSS2 Protein, Partial
E80017
  • EUR 423.50
  • EUR 660.00
  • EUR 2321.00
  • 20 ul
  • 100 ul
  • 1 ml

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial
E80018
  • EUR 388.30
  • EUR 860.20
  • EUR 4888.40
  • 20 ul
  • 100 ul
  • 1 ml

Ataxin-3 (Phospho-Ser256) Antibody
12574-100ul 100ul
EUR 302.4

Ataxin-3 (Phospho-Ser256) Antibody
12574-50ul 50ul
EUR 224.4

Ataxin 3 / ATX3 (ATXN3) Antibody
abx038360-100ug 100 ug
EUR 469.2

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx001155
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx111106
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody
abx036768-100ug 100 ug
EUR 469.2

Ataxin- 3 (Phospho- Ser256) Antibody
ABF8242 100 ug
EUR 525.6

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx225054
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody
20-abx318334
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Phospho-Ataxin 3 (Ser256) Antibody
AF8242 200ul
EUR 540

Ataxin 3 Polyclonal Conjugated Antibody
C27857 100ul
EUR 476.4

Anti-Ataxin 3/ATXN3 Antibody
PA1846 100ug/vial
EUR 400.8

Anti-Ataxin 3/ATXN3 Antibody
PB9423 100ug/vial
EUR 400.8

Ataxin-3-Like Protein (ATXN3L) Antibody
abx230742-100ug 100 ug
EUR 577.2

Ataxin-3-Like Protein (ATXN3L) Antibody
abx230743-100ug 100 ug
EUR 610.8

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)
20-abx303178
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)
20-abx303179
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody (Biotin)
20-abx303180
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Phospho-Ataxin-3 (Ser256) Blocking Peptide
AF8242-BP 1mg
EUR 234

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit
E02A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit
E04A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit
E07A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit
E06A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit
E01A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit
E03A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit
E08A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Chicken Ataxin- 3, ATXN3 ELISA KIT
ELI-24058c 96 Tests
EUR 1113.6

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit
E09A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin- 3, Atxn3 ELISA KIT
ELI-11387m 96 Tests
EUR 1038

Human Ataxin- 3, ATXN3 ELISA KIT
ELI-11466h 96 Tests
EUR 988.8

ATXN3 Ataxin-3 Human Recombinant Protein
PROTP54252 Regular: 10ug
EUR 380.4
Description: ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.;ATXN3 is purified by proprietary chromatographic techniques.

Human Ataxin 3(ATXN3)ELISA Kit
QY-E01558 96T
EUR 433.2

Ataxin 2 antibody
70R-50365 100 ul
EUR 292.8
Description: Purified Polyclonal Ataxin 2 antibody

Ataxin 10 antibody
70R-50914 100 ul
EUR 292.8
Description: Purified Polyclonal Ataxin 10 antibody

Ataxin 1 Antibody
ABF6347 100 ug
EUR 525.6

Ataxin 1 Antibody
AF6347 200ul
EUR 420

Ataxin-2 Antibody
R31210 100 ug
EUR 419

EpiQuik Dnmt1 Assay Kit 
P-3011
  • EUR 1067.46
  • EUR 512.60
  • EUR 724.90
  • 96 Assays
  • 48 Assays
  • 96 Assays

EpiQuik Dnmt3A Assay Kit 
P-3012
  • EUR 1067.46
  • EUR 503.80
  • EUR 710.60
  • 96 Assays
  • 48 Assays
  • 96 Assays

EpiQuik Dnmt3B Assay Kit 
P-3013
  • EUR 1067.46
  • EUR 503.80
  • EUR 710.60
  • 96 Assays
  • 48 Assays
  • 96 Assays

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
20-abx121023
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
abx037189-100ug 100 ug
EUR 469.2

Ataxin-7-Like Protein 3 (ATXN7L3) Antibody
20-abx301379
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 7 Like 3 (ATXN7L3) Antibody (HRP)
20-abx306773
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 7 Like 3 (ATXN7L3) Antibody (FITC)
20-abx306774
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 7 Like 3 (ATXN7L3) Antibody (Biotin)
20-abx306775
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Ataxin 3 / ATX3 (ATXN3) ELISA Kit
abx259421-96tests 96 tests
EUR 990

Ataxin-3 (Phospho-Ser256) Polyclonal Conjugated Antibody
C12574 100ul
EUR 476.4

Guinea pig Ataxin 3(ATXN3) ELISA kit
E05A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Ataxin 3(ATXN3) ELISA kit
E05A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Ataxin 3(ATXN3) ELISA kit
E05A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody
M02431-3 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

IL-3 Interleukin-3 Human Recombinant Protein, His Tag
PROTP08700-3 Regular: 50ug
EUR 380.4
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Individual Reaction Mix 3
G065-3 200 reactions
EUR 200.4

3-D Life Thioglycerol
T10-3 180 µl
EUR 57.6

Organic Wine Standard 3
WINE-3 1ML
EUR 258.78

Anti-Ataxin-2L Antibody
A08149 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Ataxin-2L Antibody (ATXN2L) detection. Tested with WB in Human.

Ataxin-1 Polyclonal Antibody
40621-100ul 100ul
EUR 302.4

Ataxin-1 Polyclonal Antibody
40621-50ul 50ul
EUR 224.4

Ataxin-2 Polyclonal Antibody
40622-100ul 100ul
EUR 302.4

Ataxin-2 Polyclonal Antibody
40622-50ul 50ul
EUR 224.4

Ataxin-2L Polyclonal Antibody
40623-100ul 100ul
EUR 302.4

Ataxin-2L Polyclonal Antibody
40623-50ul 50ul
EUR 224.4

Ataxin 10 (ATXN10) Antibody
20-abx148456
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Ataxin 7 (ATXN7) Antibody
20-abx148459
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Ataxin 7L2 Blocking Peptide
20-abx161022
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 7L3 Blocking Peptide
20-abx161023
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 1 (ATXN1) Antibody
20-abx171342
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Ataxin 10 (ATXN10) Antibody
20-abx171343
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Ataxin 1 (ATXN1) Antibody
20-abx133167
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ataxin 1 (ATXN1) Antibody
abx145346-100ug 100 ug
EUR 469.2

Ataxin 7 Blocking Peptide
20-abx161290
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 7L1 Blocking Peptide
20-abx161291
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 1 Blocking Peptide
20-abx161786
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin-1 Polyclonal Antibody
ABP50719-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-1 Polyclonal Antibody
ABP50719-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-1 Polyclonal Antibody
ABP50719-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776

Ataxin-2 Polyclonal Antibody
ABP50720-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-2 Polyclonal Antibody
ABP50720-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-2 Polyclonal Antibody
ABP50720-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780

Ataxin-2L Polyclonal Antibody
ABP53629-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620

Ataxin-2L Polyclonal Antibody
ABP53629-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620

Ataxin-2L Polyclonal Antibody
ABP53629-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620

Ataxin 2 Blocking Peptide
20-abx063240
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 10 Blocking Peptide
20-abx063789
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Ataxin 1 (ATXN1) Antibody
20-abx100304
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ataxin 10 (ATXN10) Antibody
abx037722-100ug 100 ug
EUR 469.2

Ataxin 2 (ATXN2) Antibody
abx038116-100ug 100 ug
EUR 469.2

Ataxin 7 (ATXN7) Antibody
abx038315-100ug 100 ug
EUR 469.2

Ataxin 1 (ATXN1) Antibody
20-abx004749
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ataxin-7L1 Polyclonal Antibody
ABP54236-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490
Conclusions: Our examine factors to molecular mechanisms of SCA1 linked from each mobile and animal fashions and suggests medication that could possibly be examined to find out whether or not they have an effect on the aggregation of pathogenic ATXN1 and SCA1 illness development.

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