In view of upcoming scientific trials, quantitative molecular markers accessible in peripheral blood are of important significance as prognostic or pharmacodynamic markers in genetic neurodegenerative ailments comparable to Spinocerebellar Ataxia Kind 3 (SCA3), specifically for signaling goal engagement. On this pilot examine, we centered on the quantification of ataxin-3, the protein altered in SCA3, in human peripheral blood mononuclear cells (PBMCs) acquired from preataxic and ataxic SCA3 mutation carriers in addition to wholesome controls, as a molecular marker immediately associated to SCA3 pathophysiology.
We established two completely different extremely delicate TR-FRET-based immunoassays to measure the protein ranges of both complete full-length, non-expanded and expanded, ataxin-Three or particularly polyQ-expanded ataxin-3. In PBMCs, a transparent discrimination between SCA3 mutation service and controls had been seen measuring polyQ-expanded ataxin-Three protein stage. Moreover, polyQ-expanded ataxin-Three protein ranges correlated with illness development and scientific severity as assessed by the Scale for the Evaluation and Score of Ataxia. Complete full-length ataxin-Three protein ranges had been immediately influenced by the expression ranges of the polyQ-expanded ataxin-Three protein, however weren’t correlated with scientific parameters. Evaluation of ataxin-Three ranges in fibroblasts or induced pluripotent stem cells allowed to differentiate mutation carriers from controls, thus offering proof-of-principle validation of our PBMC findings throughout cell traces.
Complete full-length or polyQ-expanded ataxin-Three protein was not detectable by TR-FRET assays in different biofluids like plasma or cerebrospinal fluid, indicating the necessity for ultra-sensitive assays for these biofluids. Standardization research revealed that tube techniques, blood sampling, and PBMC preparation could affect ataxin-Three protein ranges indicating a excessive demand for standardized protocols in biomarker research. In conclusion, the polyQ-expanded ataxin-Three protein is a promising candidate as a molecular goal engagement marker in SCA3 in future scientific trials, determinable even in-easily accessible-peripheral blood biomaterials. These outcomes, nevertheless, require validation in a bigger cohort and additional standardization of modifying situations.
Capturing the Conformational Ensemble of the Blended Folded Polyglutamine Protein Ataxin-3
Ataxin-Three is a deubiquitinase concerned in protein high quality management and different important mobile capabilities. It preferentially interacts with polyubiquitin chains of 4 or extra items hooked up to proteins delivered to the ubiquitin-proteasome system. Ataxin-Three consists of an N-terminal Josephin area and a versatile C terminus that comprises two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine tract, which, when expanded past a threshold, results in protein aggregation and misfolding and causes spinocerebellar ataxia kind 3. The high-resolution construction of the Josephin area is offered, however the structural and dynamical heterogeneity of ataxin-Three has to this point hindered the structural description of the full-length protein.
Right here, we characterize non-expanded and expanded variants of ataxin-Three by way of conformational ensembles adopted by the proteins in resolution by collectively utilizing experimental knowledge from nuclear magnetic resonance and small-angle X-ray scattering with coarse-grained simulations. Our outcomes pave the best way to a molecular understanding of polyubiquitin recognition. Right here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human organic fluids and discriminates sufferers with SCA3 from wholesome controls and people with different ataxias. We present that polyQ ATXN3 serves as a marker of goal engagement in human fibroblasts, which can bode properly for its use in scientific trials.
Final, we recognized a single-nucleotide polymorphism that strongly associates with the expanded allele, thus offering an thrilling drug goal to abrogate detrimental occasions initiated by mutant ATXN3. Gene-silencing methods for a number of repeat ailments are properly underneath method, and our outcomes are anticipated to enhance scientific trial preparedness for SCA3 therapies.
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study
Dynamics of a Protein Interplay Community Related to the Aggregation of polyQ-Expanded Ataxin-1
Background: A number of experimental fashions of polyglutamine (polyQ) ailments have been beforehand developed which can be helpful for learning illness development within the primarily affected central nervous system. Nevertheless, there’s a lacking hyperlink between mobile and animal fashions that may point out the molecular defects occurring in neurons and are chargeable for the illness phenotype in vivo.
Strategies: Right here, we used a computational method to establish dysregulated pathways shared by an in vitro and an in vivo mannequin of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ illness spinocerebellar ataxia type-1 (SCA1).
Outcomes: A set of widespread dysregulated pathways had been recognized, which had been utilized to assemble cerebellum-specific protein-protein interplay (PPI) networks at numerous time-points of protein aggregation. Evaluation of a SCA1 community indicated essential nodes which regulate its perform and may characterize potential pharmacological targets. Moreover, a set of medicine interacting with these nodes and predicted to enter the blood-brain barrier (BBB) was recognized.
 Ataxin 3 antibody |
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| 70R-13630 | Fitzgerald | 100 ul | EUR 457 |
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Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody |
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 Ataxin-3 Protein |
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| 20-abx262861 | Abbexa |
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Ataxin 3 antibody |
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| 22437-100ul | SAB | 100ul | EUR 390 |
 Antibody) Ataxin-3 (pS256) Antibody |
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| abx148457-100ug | Abbexa | 100 ug | EUR 439 |
 Ataxin 3 Rabbit pAb |
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| A1243-100ul | Abclonal | 100 ul | EUR 308 |
Ataxin 3 Rabbit pAb |
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| A1243-200ul | Abclonal | 200 ul | EUR 459 |
Ataxin 3 Rabbit pAb |
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| A1243-20ul | Abclonal | 20 ul | EUR 183 |
Ataxin 3 Rabbit pAb |
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| A1243-50ul | Abclonal | 50 ul | EUR 223 |
Ataxin 3 Rabbit pAb |
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| A12992-100ul | Abclonal | 100 ul | EUR 308 |
Ataxin 3 Rabbit pAb |
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| A12992-200ul | Abclonal | 200 ul | EUR 459 |
Ataxin 3 Rabbit pAb |
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| A12992-20ul | Abclonal | 20 ul | EUR 183 |
Ataxin 3 Rabbit pAb |
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| A12992-50ul | Abclonal | 50 ul | EUR 223 |
 Recombinant Human Ataxin-3 |
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| 7-04462 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04463 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04464 | CHI Scientific | 1mg | Ask for price |
 Ataxin 3 Polyclonal Antibody |
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| 27857-100ul | SAB | 100ul | EUR 252 |
Ataxin 3 Polyclonal Antibody |
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| 27857-50ul | SAB | 50ul | EUR 187 |
 Antibody) Phospho-Ataxin-3 (Ser256) Antibody |
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| AF8242 | Affbiotech | 200ul | EUR 376 |
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Description: Ataxin-3 (Phospho-Ser256) Antibody detects endogenous levels of Ataxin-3 only when phosphorylated at Ser256. |
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 Antibody) Ataxin- 3 (Phospho- Ser256) Antibody |
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| ABF8242 | Lifescience Market | 100 ug | EUR 438 |
 Anti-Ataxin 3/ATXN3 Antibody |
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| PA1846 | BosterBio | 100ug/vial | EUR 334 |
Anti-Ataxin 3/ATXN3 Antibody |
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| PB9423 | BosterBio | 100ug/vial | EUR 334 |
 Antibody) Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx111106 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| abx038360-100ug | Abbexa | 100 ug | EUR 391 |
Ataxin 3 / ATX3 (ATXN3) Antibody |
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| abx036768-100ug | Abbexa | 100 ug | EUR 391 |
Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx001155 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx318334 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx225054 | Abbexa |
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 Antibody) Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-100ul | SAB | 100ul | EUR 252 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-50ul | SAB | 50ul | EUR 187 |
 Ataxin 3 Polyclonal Conjugated Antibody |
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| C27857 | SAB | 100ul | EUR 397 |
 Mouse Ataxin- 3, Atxn3 ELISA KIT |
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| ELI-11387m | Lifescience Market | 96 Tests | EUR 865 |
 Human Ataxin- 3, ATXN3 ELISA KIT |
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| ELI-11466h | Lifescience Market | 96 Tests | EUR 824 |
 Chicken Ataxin- 3, ATXN3 ELISA KIT |
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| ELI-24058c | Lifescience Market | 96 Tests | EUR 928 |
 Blocking Peptide) Phospho-Ataxin-3 (Ser256) Blocking Peptide |
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| AF8242-BP | Affbiotech | 1mg | EUR 195 |
 ELISA kit) Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Antibody (HRP)) Ataxin 3 / ATX3 (ATXN3) Antibody (HRP) |
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| 20-abx303178 | Abbexa |
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 Antibody (FITC)) Ataxin 3 / ATX3 (ATXN3) Antibody (FITC) |
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| 20-abx303179 | Abbexa |
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 Antibody (Biotin)) Ataxin 3 / ATX3 (ATXN3) Antibody (Biotin) |
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| 20-abx303180 | Abbexa |
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 Antibody) Ataxin-3-Like Protein (ATXN3L) Antibody |
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| abx230742-100ug | Abbexa | 100 ug | EUR 481 |
Ataxin-3-Like Protein (ATXN3L) Antibody |
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| abx230743-100ug | Abbexa | 100 ug | EUR 509 |
 ATXN3 Ataxin-3 Human Recombinant Protein |
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| PROTP54252 | BosterBio | Regular: 10ug | EUR 317 |
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Description: ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.;ATXN3 is purified by proprietary chromatographic techniques. |
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ELISA Kit) Human Ataxin 3(ATXN3)ELISA Kit |
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| QY-E01558 | Qayee Biotechnology | 96T | EUR 361 |
 Ataxin 2 antibody |
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| 70R-50365 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal Ataxin 2 antibody |
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 Ataxin 10 antibody |
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| 70R-50914 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal Ataxin 10 antibody |
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 Ataxin 1 Antibody |
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| AF6347 | Affbiotech | 200ul | EUR 304 |
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Description: Ataxin 1 Antibody detects endogenous levels of total Ataxin 1. |
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Ataxin 1 Antibody |
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| ABF6347 | Lifescience Market | 100 ug | EUR 438 |
 Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody |
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| M02431-3 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
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 IL-3 Interleukin-3 Human Recombinant Protein, His Tag |
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| PROTP08700-3 | BosterBio | Regular: 50ug | EUR 317 |
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Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques. |
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 ELISA kit) Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Antibody) Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx301379 | Abbexa |
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 Antibody (HRP)) Ataxin 7 Like 3 (ATXN7L3) Antibody (HRP) |
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| 20-abx306773 | Abbexa |
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 Antibody (FITC)) Ataxin 7 Like 3 (ATXN7L3) Antibody (FITC) |
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| 20-abx306774 | Abbexa |
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 Antibody (Biotin)) Ataxin 7 Like 3 (ATXN7L3) Antibody (Biotin) |
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| 20-abx306775 | Abbexa |
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx121023 | Abbexa |
|
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| abx037189-100ug | Abbexa | 100 ug | EUR 391 |
 ELISA Kit) Human Ataxin 3 / ATX3 (ATXN3) ELISA Kit |
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| abx259421-96tests | Abbexa | 96 tests | EUR 825 |
 Polyclonal Conjugated Antibody) Ataxin-3 (Phospho-Ser256) Polyclonal Conjugated Antibody |
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| C12574 | SAB | 100ul | EUR 397 |
 Individual Reaction Mix 3 |
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| G065-3 | ABM | 200 reactions | EUR 167 |
 3-D Life Thioglycerol |
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| T10-3 | Cellendes | 180 µl | EUR 48 |
 Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm |
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| B1200-3 | MTC Bio | 5/pack | EUR 63.77 |
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Description: Western Blot Boxes |
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 TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant |
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| PROTP10600-3 | BosterBio | Regular: 5ug | EUR 317 |
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Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques. |
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 pLenti-CARM1 shRNA-3 Plasmid |
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| PVTBAV03691-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-CTLA4 shRNA-3 Plasmid |
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| PVTBAV05689-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-FOXM1 shRNA-3 Plasmid |
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| PVTBAV08732-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-JUN shRNA-3 Plasmid |
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| PVTBAV11741-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-LHX6 shRNA-3 Plasmid |
|||
| PVTBAV12881-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-MAGEA3 shRNA-3 Plasmid |
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| PVTBAV13661-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-RUNX3 shRNA-3 Plasmid |
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| PVTBAV20583-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-Slc7a11 shRNA-3 Plasmid |
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| PVTBAV21973-3 | Lifescience Market | 2 ug | EUR 356 |
 pLenti-STAT3 shRNA-3 Plasmid |
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| PVTBAV22921-3 | Lifescience Market | 2 ug | EUR 356 |
 Dr. P Kit-Solution 3 |
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| K2021010-3 | Biochain | 50 ml | EUR 133 |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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 3-D Life PEG-Link |
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| L50-3 | Cellendes | 3x 200 µl | EUR 94 |
 3-D Life CD-Link |
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| L60-3 | Cellendes | 3 x 200 µl | EUR 321 |
 3-D-Life SG-PVA |
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| M81-3 | Cellendes | 3x 170 µl | EUR 148 |
 3-D Life FG-PVA |
|||
| M82-3 | Cellendes | 3x 170 µl | EUR 148 |
 3-D Life FG-Dextran |
|||
| M92-3 | Cellendes | 3x 170 µl | EUR 157 |
 3-D Life RGD Peptide |
|||
| P10-3 | Cellendes | 3x 1 µmol | EUR 276 |
 Recombinant Human MMP-3 Protein |
|||
| PROTP08254-3 | BosterBio | 10ug | EUR 317 |
|
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids). |
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 3-D Life SG-Dextran |
|||
| M91-3 | Cellendes | 3x 170 µl | EUR 157 |
 Ataxin 1 Blocking Peptide |
|||
| AF6347-BP | Affbiotech | 1mg | EUR 195 |
) Anti-Ataxin 1 (4C5) |
|||
| YF-MA15341 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Ataxin 1 |
|||
) Recombinant Ataxin 10 (ATXN10) |
|||
| 4-RPD248Hu01 | Cloud-Clone |
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Description: Recombinant Human Ataxin 10 expressed in: E.coli |
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) Recombinant Ataxin 1 (ATXN1) |
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| 4-RPA514Hu01 | Cloud-Clone |
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Description: Recombinant Human Ataxin 1 expressed in: E.coli |
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Recombinant Ataxin 1 (ATXN1) |
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| 4-RPA514Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Ataxin 1 expressed in: E.coli |
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 Anti-Ataxin 2 antibody |
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| PAab00657 | Lifescience Market | 100 ug | EUR 355 |
 Ataxin-7L1 Polyclonal Antibody |
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| ES5235-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Ataxin-7L1 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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Ataxin-7L1 Polyclonal Antibody |
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| ES5235-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Ataxin-7L1 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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 Ataxin-2L Polyclonal Antibody |
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| ES4628-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2L from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Ataxin-2L Polyclonal Antibody |
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| ES4628-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2L from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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 Antibody) Ataxin 2 (ATXN2) Antibody |
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| 20-abx302483 | Abbexa |
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 Antibody) Ataxin 7 (ATXN7) Antibody |
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| 20-abx148459 | Abbexa |
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 Ataxin-1 Polyclonal Antibody |
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| ES1718-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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Ataxin-1 Polyclonal Antibody |
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| ES1718-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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 Ataxin-2 Polyclonal Antibody |
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| ES1719-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Ataxin-2 Polyclonal Antibody |
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| ES1719-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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 Antibody) Ataxin 1 (ATXN1) Antibody |
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| 20-abx133167 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx129635 | Abbexa |
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Ataxin 7 (ATXN7) Antibody |
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| 20-abx121290 | Abbexa |
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 Antibody) Ataxin 1 (pS775) Antibody |
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| 20-abx121842 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx126836 | Abbexa |
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 Antibody) Ataxin 10 (ATXN10) Antibody |
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| 20-abx128172 | Abbexa |
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Ataxin 10 (ATXN10) Antibody |
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| 20-abx111104 | Abbexa |
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Ataxin 2 (ATXN2) Antibody |
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| 20-abx111105 | Abbexa |
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Ataxin 2 (ATXN2) Antibody |
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| 20-abx124201 | Abbexa |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-2L Polyclonal Antibody |
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| ABP53629-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620 |
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Ataxin-2L Polyclonal Antibody |
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| ABP53629-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620 |
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Conclusions: Our examine factors to molecular mechanisms of SCA1 linked from each mobile and animal fashions and suggests medication that could possibly be examined to find out whether or not they have an effect on the aggregation of pathogenic ATXN1 and SCA1 illness development.