In view of upcoming scientific trials, quantitative molecular markers accessible in peripheral blood are of important significance as prognostic or pharmacodynamic markers in genetic neurodegenerative ailments comparable to Spinocerebellar Ataxia Kind 3 (SCA3), specifically for signaling goal engagement. On this pilot examine, we centered on the quantification of ataxin-3, the protein altered in SCA3, in human peripheral blood mononuclear cells (PBMCs) acquired from preataxic and ataxic SCA3 mutation carriers in addition to wholesome controls, as a molecular marker immediately associated to SCA3 pathophysiology.
We established two completely different extremely delicate TR-FRET-based immunoassays to measure the protein ranges of both complete full-length, non-expanded and expanded, ataxin-Three or particularly polyQ-expanded ataxin-3. In PBMCs, a transparent discrimination between SCA3 mutation service and controls had been seen measuring polyQ-expanded ataxin-Three protein stage. Moreover, polyQ-expanded ataxin-Three protein ranges correlated with illness development and scientific severity as assessed by the Scale for the Evaluation and Score of Ataxia. Complete full-length ataxin-Three protein ranges had been immediately influenced by the expression ranges of the polyQ-expanded ataxin-Three protein, however weren’t correlated with scientific parameters. Evaluation of ataxin-Three ranges in fibroblasts or induced pluripotent stem cells allowed to differentiate mutation carriers from controls, thus offering proof-of-principle validation of our PBMC findings throughout cell traces.
Complete full-length or polyQ-expanded ataxin-Three protein was not detectable by TR-FRET assays in different biofluids like plasma or cerebrospinal fluid, indicating the necessity for ultra-sensitive assays for these biofluids. Standardization research revealed that tube techniques, blood sampling, and PBMC preparation could affect ataxin-Three protein ranges indicating a excessive demand for standardized protocols in biomarker research. In conclusion, the polyQ-expanded ataxin-Three protein is a promising candidate as a molecular goal engagement marker in SCA3 in future scientific trials, determinable even in-easily accessible-peripheral blood biomaterials. These outcomes, nevertheless, require validation in a bigger cohort and additional standardization of modifying situations.
Capturing the Conformational Ensemble of the Blended Folded Polyglutamine Protein Ataxin-3
Ataxin-Three is a deubiquitinase concerned in protein high quality management and different important mobile capabilities. It preferentially interacts with polyubiquitin chains of 4 or extra items hooked up to proteins delivered to the ubiquitin-proteasome system. Ataxin-Three consists of an N-terminal Josephin area and a versatile C terminus that comprises two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine tract, which, when expanded past a threshold, results in protein aggregation and misfolding and causes spinocerebellar ataxia kind 3. The high-resolution construction of the Josephin area is offered, however the structural and dynamical heterogeneity of ataxin-Three has to this point hindered the structural description of the full-length protein.
Right here, we characterize non-expanded and expanded variants of ataxin-Three by way of conformational ensembles adopted by the proteins in resolution by collectively utilizing experimental knowledge from nuclear magnetic resonance and small-angle X-ray scattering with coarse-grained simulations. Our outcomes pave the best way to a molecular understanding of polyubiquitin recognition. Right here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human organic fluids and discriminates sufferers with SCA3 from wholesome controls and people with different ataxias. We present that polyQ ATXN3 serves as a marker of goal engagement in human fibroblasts, which can bode properly for its use in scientific trials.
Final, we recognized a single-nucleotide polymorphism that strongly associates with the expanded allele, thus offering an thrilling drug goal to abrogate detrimental occasions initiated by mutant ATXN3. Gene-silencing methods for a number of repeat ailments are properly underneath method, and our outcomes are anticipated to enhance scientific trial preparedness for SCA3 therapies.
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study
Dynamics of a Protein Interplay Community Related to the Aggregation of polyQ-Expanded Ataxin-1
Background: A number of experimental fashions of polyglutamine (polyQ) ailments have been beforehand developed which can be helpful for learning illness development within the primarily affected central nervous system. Nevertheless, there’s a lacking hyperlink between mobile and animal fashions that may point out the molecular defects occurring in neurons and are chargeable for the illness phenotype in vivo.
Strategies: Right here, we used a computational method to establish dysregulated pathways shared by an in vitro and an in vivo mannequin of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ illness spinocerebellar ataxia type-1 (SCA1).
Outcomes: A set of widespread dysregulated pathways had been recognized, which had been utilized to assemble cerebellum-specific protein-protein interplay (PPI) networks at numerous time-points of protein aggregation. Evaluation of a SCA1 community indicated essential nodes which regulate its perform and may characterize potential pharmacological targets. Moreover, a set of medicine interacting with these nodes and predicted to enter the blood-brain barrier (BBB) was recognized.
Ataxin 3 protein |
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| 30R-1344 | Fitzgerald | 50 ug | EUR 366 |
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Description: Purified recombinant Human Ataxin 3 protein |
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Ataxin 3 antibody |
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| 22437-100ul | SAB | 100ul | EUR 468 |
Ataxin 3 antibody |
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| 70R-13630 | Fitzgerald | 100 ul | EUR 548.4 |
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Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody |
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Ataxin 3 Antibody |
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| DF6375 | Affbiotech | 200ul | EUR 420 |
Ataxin-3 (pS256) Antibody |
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| abx148457-100ug | Abbexa | 100 ug | EUR 526.8 |
Recombinant Human Ataxin-3 |
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| 7-04462 | CHI Scientific | 2µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04463 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Ataxin-3 |
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| 7-04464 | CHI Scientific | 1mg | Ask for price |
Ataxin 3 Rabbit pAb |
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| A1243-100ul | Abclonal | 100 ul | EUR 369.6 |
Ataxin 3 Rabbit pAb |
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| A1243-200ul | Abclonal | 200 ul | EUR 550.8 |
Ataxin 3 Rabbit pAb |
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| A1243-20ul | Abclonal | 20 ul | EUR 219.6 |
Ataxin 3 Rabbit pAb |
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| A1243-50ul | Abclonal | 50 ul | EUR 267.6 |
Ataxin 3 Rabbit pAb |
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| A12992-100ul | Abclonal | 100 ul | EUR 369.6 |
Ataxin 3 Rabbit pAb |
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| A12992-200ul | Abclonal | 200 ul | EUR 550.8 |
Ataxin 3 Rabbit pAb |
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| A12992-20ul | Abclonal | 20 ul | EUR 219.6 |
Ataxin 3 Rabbit pAb |
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| A12992-50ul | Abclonal | 50 ul | EUR 267.6 |
Ataxin 3 Antibody / ATXN3 |
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| F55027-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. |
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Ataxin 3 Antibody / ATXN3 |
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| F55027-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. |
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Ataxin 3 Antibody / ATXN3 |
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| R32137 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: ATXN3 (Ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 ranges in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation. Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3. |
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Ataxin 3 Polyclonal Antibody |
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| 27857-100ul | SAB | 100ul | EUR 302.4 |
Ataxin 3 Polyclonal Antibody |
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| 27857-50ul | SAB | 50ul | EUR 224.4 |
Ataxin 3 Polyclonal Antibody |
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| A70452 | EpiGentek |
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Ataxin-3 Fluorescent Assay Kit |
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| 78044 | BPS Bioscience | 96 rxns. | EUR 765 |
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Description: The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. |
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Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-100ul | SAB | 100ul | EUR 302.4 |
Ataxin-3 (Phospho-Ser256) Antibody |
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| 12574-50ul | SAB | 50ul | EUR 224.4 |
Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx318334 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx225054 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx111106 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody |
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| abx036768-100ug | Abbexa | 100 ug | EUR 469.2 |
Ataxin 3 / ATX3 (ATXN3) Antibody |
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| abx038360-100ug | Abbexa | 100 ug | EUR 469.2 |
Ataxin 3 / ATX3 (ATXN3) Antibody |
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| 20-abx001155 | Abbexa |
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Ataxin-2 Antibody |
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| R31210 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Ataxin-2, the protein encoded by the ATXN2 gene, contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2(SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and overexpression leads to accumulation of T-plastin in mammalian cells. |
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Ataxin- 3 (Phospho- Ser256) Antibody |
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| ABF8242 | Lifescience Market | 100 ug | EUR 525.6 |
Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Ataxin 3(ATXN3) ELISA kit |
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| E08A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Ataxin 3(ATXN3) ELISA kit |
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| E02A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Ataxin 3(ATXN3) ELISA kit |
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| E07A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Ataxin 3(ATXN3) ELISA kit |
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| E06A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Ataxin 1 Antibody |
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| AF6347 | Affbiotech | 200ul | EUR 420 |
Ataxin 10 antibody |
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| 70R-50914 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Ataxin 10 antibody |
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Ataxin 2 antibody |
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| 70R-50365 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Ataxin 2 antibody |
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Ataxin 1 Antibody |
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| ABF6347 | Lifescience Market | 100 ug | EUR 525.6 |
Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin 3(ATXN3) ELISA kit |
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| E03A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Ataxin 3(ATXN3) ELISA kit |
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| E01A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Ataxin- 3, Atxn3 ELISA KIT |
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| ELI-11387m | Lifescience Market | 96 Tests | EUR 1038 |
Human Ataxin- 3, ATXN3 ELISA KIT |
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| ELI-11466h | Lifescience Market | 96 Tests | EUR 988.8 |
Human Ataxin 3(ATXN3)ELISA Kit |
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| QY-E01558 | Qayee Biotechnology | 96T | EUR 433.2 |
Ataxin-3-Like Protein (ATXN3L) Antibody |
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| abx230742-100ug | Abbexa | 100 ug | EUR 577.2 |
Ataxin-3-Like Protein (ATXN3L) Antibody |
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| abx230743-100ug | Abbexa | 100 ug | EUR 610.8 |
Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Ataxin 3(ATXN3) ELISA kit |
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| E04A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Ataxin 3(ATXN3) ELISA kit |
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| E09A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Ataxin 3 Polyclonal Conjugated Antibody |
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| C27857 | SAB | 100ul | EUR 476.4 |
ATXN3 Ataxin-3 Human Recombinant Protein |
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| PROTP54252 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.;ATXN3 is purified by proprietary chromatographic techniques. |
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Ataxin 3 / ATX3 (ATXN3) Antibody (HRP) |
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| 20-abx303178 | Abbexa |
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Chicken Ataxin- 3, ATXN3 ELISA KIT |
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| ELI-24058c | Lifescience Market | 96 Tests | EUR 1113.6 |
Ataxin 3 / ATX3 (ATXN3) Antibody (FITC) |
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| 20-abx303179 | Abbexa |
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Ataxin 3 / ATX3 (ATXN3) Antibody (Biotin) |
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| 20-abx303180 | Abbexa |
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Ataxin-2 Antibody / ATXN2 |
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| R32313 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Ataxin-2, or ATX2, protein is encoded by the ATXN2 gene and contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2 (SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and that overexpression of ataxin-2 leads to accumulation of T-plastin in mammalian cells. |
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx121023 | Abbexa |
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Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| abx037189-100ug | Abbexa | 100 ug | EUR 469.2 |
Ataxin-7-Like Protein 3 (ATXN7L3) Antibody |
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| 20-abx301379 | Abbexa |
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Ataxin-1 Polyclonal Antibody |
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| 40621-100ul | SAB | 100ul | EUR 302.4 |
Ataxin-1 Polyclonal Antibody |
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| 40621-50ul | SAB | 50ul | EUR 224.4 |
Ataxin-2 Polyclonal Antibody |
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| 40622-100ul | SAB | 100ul | EUR 302.4 |
Ataxin-2 Polyclonal Antibody |
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| 40622-50ul | SAB | 50ul | EUR 224.4 |
Ataxin-1 Polyclonal Antibody |
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| ABP50719-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776 |
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Ataxin-1 Polyclonal Antibody |
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| ABP50719-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776 |
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Ataxin-1 Polyclonal Antibody |
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| ABP50719-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Ataxin-1 from Human, Mouse. This Ataxin-1 antibody is for WB , IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Ataxin-1 around the non-phosphorylation site of S776 |
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Ataxin-2 Polyclonal Antibody |
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| ABP50720-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780 |
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Ataxin-2 Polyclonal Antibody |
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| ABP50720-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780 |
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Ataxin-2 Polyclonal Antibody |
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| ABP50720-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Ataxin-2 from Human. This Ataxin-2 antibody is for WB , IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2 at AA range: 700-780 |
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Ataxin-1 Polyclonal Antibody |
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| ES1718-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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Ataxin-1 Polyclonal Antibody |
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| ES1718-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Ataxin-1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
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Ataxin-2 Polyclonal Antibody |
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| ES1719-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Ataxin-2 Polyclonal Antibody |
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| ES1719-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Human Ataxin 3 / ATX3 (ATXN3) ELISA Kit |
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| abx259421-96tests | Abbexa | 96 tests | EUR 990 |
Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Ataxin 3(ATXN3) ELISA kit |
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| E05A1769-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Ataxin-2L Polyclonal Antibody |
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| 40623-100ul | SAB | 100ul | EUR 302.4 |
Ataxin-2L Polyclonal Antibody |
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| 40623-50ul | SAB | 50ul | EUR 224.4 |
Ataxin-2L Polyclonal Antibody |
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| ABP53629-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620 |
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Ataxin-2L Polyclonal Antibody |
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| ABP53629-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620 |
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Ataxin-2L Polyclonal Antibody |
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| ABP53629-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Ataxin-2L from Human. This Ataxin-2L antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-2L at AA rangle: 540-620 |
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Ataxin-2L Polyclonal Antibody |
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| ES4628-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2L from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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Ataxin-2L Polyclonal Antibody |
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| ES4628-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Ataxin-2L from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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anti- Ataxin 2 antibody |
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| FNab00657 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Ataxin 2 |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-7L1 Polyclonal Antibody |
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| ABP54236-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Ataxin-7L1 from Human, Mouse. This Ataxin-7L1 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Ataxin-7L1 at AA rangle: 410-490 |
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Ataxin-7L1 Polyclonal Antibody |
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| ES5235-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Ataxin-7L1 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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Ataxin-7L1 Polyclonal Antibody |
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| ES5235-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Ataxin-7L1 from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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Ataxin 7 Like 3 (ATXN7L3) Antibody (HRP) |
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| 20-abx306773 | Abbexa |
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Ataxin 2 (ATXN2) Antibody |
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| abx230657-100ug | Abbexa | 100 ug | EUR 577.2 |
Ataxin 1 (ATXN1) Antibody |
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| 20-abx242069 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx100304 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx171342 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx214569 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx133167 | Abbexa |
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Ataxin 7 (ATXN7) Antibody |
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| 20-abx121290 | Abbexa |
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Ataxin 1 (pS775) Antibody |
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| 20-abx121842 | Abbexa |
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Ataxin 7 (ATXN7) Antibody |
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| 20-abx148459 | Abbexa |
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Ataxin 2 (ATXN2) Antibody |
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| 20-abx324514 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx325351 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| abx445066-100ug | Abbexa | 100 ug | EUR 627.6 |
Ataxin 1 (ATXN1) Antibody |
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| abx445084-100ug | Abbexa | 100 ug | EUR 627.6 |
Ataxin 2 (ATXN2) Antibody |
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| 20-abx111105 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| abx031721-400ul | Abbexa | 400 ul | EUR 627.6 |
Ataxin 1 (ATXN1) Antibody |
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| abx031721-80l | Abbexa | 80 µl | EUR 343.2 |
Ataxin 7 (ATXN7) Antibody |
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| abx029159-400ul | Abbexa | 400 ul | EUR 627.6 |
Ataxin 7 (ATXN7) Antibody |
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| abx029159-80l | Abbexa | 80 µl | EUR 343.2 |
Ataxin 2 (ATXN2) Antibody |
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| abx038116-100ug | Abbexa | 100 ug | EUR 469.2 |
Ataxin 7 (ATXN7) Antibody |
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| abx038315-100ug | Abbexa | 100 ug | EUR 469.2 |
Ataxin 1 (ATXN1) Antibody |
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| 20-abx126836 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx129635 | Abbexa |
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Ataxin 2 (ATXN2) Antibody |
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| 20-abx124201 | Abbexa |
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Ataxin 7 (ATXN7) Antibody |
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| 20-abx338870 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| 20-abx320078 | Abbexa |
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Ataxin 1 (ATXN1) Antibody |
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| abx431572-200ul | Abbexa | 200 ul | EUR 343.2 |
Conclusions: Our examine factors to molecular mechanisms of SCA1 linked from each mobile and animal fashions and suggests medication that could possibly be examined to find out whether or not they have an effect on the aggregation of pathogenic ATXN1 and SCA1 illness development.