PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

In view of upcoming scientific trials, quantitative molecular markers accessible in peripheral blood are of important significance as prognostic or pharmacodynamic markers in genetic neurodegenerative ailments comparable to Spinocerebellar Ataxia Kind 3 (SCA3), specifically for signaling goal engagement. On this pilot examine, we centered on the quantification of ataxin-3, the protein altered in SCA3, in human peripheral blood mononuclear cells (PBMCs) acquired from preataxic and ataxic SCA3 mutation carriers in addition to wholesome controls, as a molecular marker immediately associated to SCA3 pathophysiology.

 

We established two completely different extremely delicate TR-FRET-based immunoassays to measure the protein ranges of both complete full-length, non-expanded and expanded, ataxin-Three or particularly polyQ-expanded ataxin-3. In PBMCs, a transparent discrimination between SCA3 mutation service and controls had been seen measuring polyQ-expanded ataxin-Three protein stage. Moreover, polyQ-expanded ataxin-Three protein ranges correlated with illness development and scientific severity as assessed by the Scale for the Evaluation and Score of Ataxia. Complete full-length ataxin-Three protein ranges had been immediately influenced by the expression ranges of the polyQ-expanded ataxin-Three protein, however weren’t correlated with scientific parameters. Evaluation of ataxin-Three ranges in fibroblasts or induced pluripotent stem cells allowed to differentiate mutation carriers from controls, thus offering proof-of-principle validation of our PBMC findings throughout cell traces.

Complete full-length or polyQ-expanded ataxin-Three protein was not detectable by TR-FRET assays in different biofluids like plasma or cerebrospinal fluid, indicating the necessity for ultra-sensitive assays for these biofluids. Standardization research revealed that tube techniques, blood sampling, and PBMC preparation could affect ataxin-Three protein ranges indicating a excessive demand for standardized protocols in biomarker research. In conclusion, the polyQ-expanded ataxin-Three protein is a promising candidate as a molecular goal engagement marker in SCA3 in future scientific trials, determinable even in-easily accessible-peripheral blood biomaterials. These outcomes, nevertheless, require validation in a bigger cohort and additional standardization of modifying situations.

 

 

Capturing the Conformational Ensemble of the Blended Folded Polyglutamine Protein Ataxin-3

Ataxin-Three is a deubiquitinase concerned in protein high quality management and different important mobile capabilities. It preferentially interacts with polyubiquitin chains of 4 or extra items hooked up to proteins delivered to the ubiquitin-proteasome system. Ataxin-Three consists of an N-terminal Josephin area and a versatile C terminus that comprises two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine tract, which, when expanded past a threshold, results in protein aggregation and misfolding and causes spinocerebellar ataxia kind 3. The high-resolution construction of the Josephin area is offered, however the structural and dynamical heterogeneity of ataxin-Three has to this point hindered the structural description of the full-length protein.
Right here, we characterize non-expanded and expanded variants of ataxin-Three by way of conformational ensembles adopted by the proteins in resolution by collectively utilizing experimental knowledge from nuclear magnetic resonance and small-angle X-ray scattering with coarse-grained simulations. Our outcomes pave the best way to a molecular understanding of polyubiquitin recognition. Right here, we developed an immunoassay that readily detects polyQ ATXN3 proteins in human organic fluids and discriminates sufferers with SCA3 from wholesome controls and people with different ataxias. We present that polyQ ATXN3 serves as a marker of goal engagement in human fibroblasts, which can bode properly for its use in scientific trials.
Final, we recognized a single-nucleotide polymorphism that strongly associates with the expanded allele, thus offering an thrilling drug goal to abrogate detrimental occasions initiated by mutant ATXN3. Gene-silencing methods for a number of repeat ailments are properly underneath method, and our outcomes are anticipated to enhance scientific trial preparedness for SCA3 therapies.
 PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study

Dynamics of a Protein Interplay Community Related to the Aggregation of polyQ-Expanded Ataxin-1

Background: A number of experimental fashions of polyglutamine (polyQ) ailments have been beforehand developed which can be helpful for learning illness development within the primarily affected central nervous system. Nevertheless, there’s a lacking hyperlink between mobile and animal fashions that may point out the molecular defects occurring in neurons and are chargeable for the illness phenotype in vivo.
Strategies: Right here, we used a computational method to establish dysregulated pathways shared by an in vitro and an in vivo mannequin of ATXN1(Q82) protein aggregation, the mutant protein that causes the neurodegenerative polyQ illness spinocerebellar ataxia type-1 (SCA1).
Outcomes: A set of widespread dysregulated pathways had been recognized, which had been utilized to assemble cerebellum-specific protein-protein interplay (PPI) networks at numerous time-points of protein aggregation. Evaluation of a SCA1 community indicated essential nodes which regulate its perform and may characterize potential pharmacological targets. Moreover, a set of medicine interacting with these nodes and predicted to enter the blood-brain barrier (BBB) was recognized.

Rabbit Polyclonal antibody to Ataxin 3 (ataxin 3)

TA308320 100 µl Ask for price

Ataxin-3 Protein

20-abx262861
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  • 10 ug
  • 1 mg
  • 2 µg

Ataxin-3 Protein

abx262861-10mg 10 mg
EUR 325

Ataxin-3 Protein

abx262861-25mg 25 mg
EUR 6575

Ataxin-3 Protein

abx262861-5mg 5 mg
EUR 225

Ataxin 3 protein

30R-1344 50 ug
EUR 307
Description: Purified recombinant Human Ataxin 3 protein

Ataxin 3 antibody

22437 100ul
EUR 479

Ataxin 3 antibody

22437-100ul 100ul
EUR 468

Ataxin 3 Antibody

DF6375 200ul
EUR 420

Ataxin 3 Antibody

DF6375-100ul 100ul
EUR 280

Ataxin 3 Antibody

DF6375-200ul 200ul
EUR 350

Ataxin 3 Antibody

E300595 100ug/200ul
EUR 275
Description: Available in various conjugation types.

Ataxin 3 antibody

70R-13630 100 ul
EUR 548
Description: Affinity purified Rabbit polyclonal Ataxin 3 antibody

Ataxin-3 (pS256) Antibody

abx148457-100ug 100 ug
EUR 526.8

Ataxin-3 Human (Recombinant)

22061141-1 2 µg
EUR 137.27

Recombinant Human Ataxin-3

7-04462 2µg Ask for price

Recombinant Human Ataxin-3

7-04463 10µg Ask for price

Recombinant Human Ataxin-3

7-04464 1mg Ask for price

Ataxin-3 Human Recombinant

rAP-4434 Inquiry Ask for price

Ataxin 3 Rabbit mAb

52716 100ul
EUR 499

Ataxin 3 Rabbit pAb

A1243-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb

A1243-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb

A1243-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb

A1243-50ul 50 ul
EUR 267.6

Ataxin 3 Rabbit pAb

A12992-100ul 100 ul
EUR 369.6

Ataxin 3 Rabbit pAb

A12992-200ul 200 ul
EUR 550.8

Ataxin 3 Rabbit pAb

A12992-20ul 20 ul
EUR 219.6

Ataxin 3 Rabbit pAb

A12992-50ul 50 ul
EUR 267.6

Ataxin 3 Rabbit mAb

E2R26443 100ul
EUR 255
Description: Available in various conjugation types.

Ataxin-10

AP80722 1mg
EUR 2640

Ataxin-10

AP80782 1mg
EUR 2640

Ataxin-10

AP81057 1mg
EUR 2640

Ataxin-10

AP81093 1mg
EUR 2640

Ataxin 3 Antibody / ATXN3

F55027-0.08ML 0.08 ml
EUR 140.25
Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers.

Ataxin 3 Antibody / ATXN3

F55027-0.4ML 0.4 ml
EUR 322.15
Description: ATXN3 was known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers.

Ataxin 3 Antibody / ATXN3

R32137 100 ug
EUR 356.15
Description: ATXN3 (Ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 ranges in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation. Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.

Ataxin-3 (ATXN3) Rabbit mAb

A22094 100μL
EUR 83.2
Description: A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Neurofilament H (P12036).

Recombinant Ataxin 3 (ATXN3)

RPD250Hu01 10ug
EUR 120

Ataxin 3 Polyclonal Antibody

27857-100ul 100ul
EUR 302.4

Ataxin 3 Polyclonal Antibody

27857-50ul 50ul
EUR 224.4

Ataxin 3 Polyclonal Antibody

A70452 50 μl
EUR 408

Ataxin 3 Polyclonal Antibody

E-AB-60279-120uL 120uL
EUR 320
Description: Unconjugated

Ataxin 3 Polyclonal Antibody

E-AB-60279-200uL 200uL
EUR 530
Description: Unconjugated

Ataxin 3 Polyclonal Antibody

E-AB-60279-60uL 60uL
EUR 200
Description: Unconjugated

Ataxin 3 Polyclonal Antibody

E-AB-60279-each each Ask for price
Description: Unconjugated

Ataxin-3 Fluorescent Assay Kit

78044 96 rxns.
EUR 765
Description: The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. 

Recombinant Human Ataxin-3 (ATXN3)

CSB-EP002443HU 11921 mg Ask for price

Ataxin-3 (Phospho-Ser256) Antibody

12574 100ul
EUR 319

Ataxin-3 (Phospho-Ser256) Antibody

12574-100ul 100ul
EUR 302.4

Ataxin-3 (Phospho-Ser256) Antibody

12574-50ul 50ul
EUR 224.4

Rat Atxn3 / Ataxin-3 ELISA Kit

E10108r 96T
EUR 796

Human Ataxin-3 (ATXN3) ELISA Kit

AE54842HU-48Tests 48 Tests
EUR 325
Description: Human (Homo sapiens)

Human Ataxin-3 (ATXN3) ELISA Kit

AE54842HU-96Tests 96 Tests
EUR 610
Description: Human (Homo sapiens)

Human Ataxin-3 (ATXN3) ELISA Kit

RK10399 96T
EUR 280

Mouse Ataxin-3 (ATXN3) ELISA Kit

RK12664 96T
EUR 280

Human ATXN3 / Ataxin-3 ELISA Kit

E10108h 96T
EUR 736

Mouse Atxn3 / Ataxin-3 ELISA Kit

E10108m 96T
EUR 776

Ataxin 3 / ATX3 (ATXN3) Antibody

20-abx111106
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  • 150 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody

abx036768-100ug 100 ug
EUR 469.2

Ataxin 3 / ATX3 (ATXN3) Antibody

abx038360-100ug 100 ug
EUR 469.2

Ataxin 3 / ATX3 (ATXN3) Antibody

20-abx001155
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody

20-abx225054
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  • 100 ul
  • 200 ul
  • 50 ul

Ataxin 3 / ATX3 (ATXN3) Antibody

20-abx318334
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody

abx001155-100l 100 µl
EUR 400

Ataxin 3 / ATX3 (ATXN3) Antibody

abx001155-20l 20 µl
EUR 175

Ataxin 3 / ATX3 (ATXN3) Antibody

abx001155-50l 50 µl
EUR 275

Ataxin 3 / ATX3 (ATXN3) Antibody

abx111106-100l 100 µl
EUR 612.5

Ataxin 3 / ATX3 (ATXN3) Antibody

abx036768-100g 100 µg
EUR 337.5

Ataxin 3 / ATX3 (ATXN3) Antibody

abx038360-100l 100 µl
EUR 337.5

Ataxin 3 / ATX3 (ATXN3) Antibody

abx318334-100l 100 µl
EUR 250

Ataxin 3 / ATX3 (ATXN3) Antibody

abx318334-50l 50 µl
EUR 162.5

Chicken ATXN3 / Ataxin-3 ELISA Kit

E10108c 96T
EUR 900

Ataxin-1 Antibody

E90506 100μg
EUR 255
Description: Available in various conjugation types.

Ataxin-2 Antibody

R31210 100 ug
EUR 356.15
Description: Ataxin-2, the protein encoded by the ATXN2 gene, contains a polyglutamine tract, long expansions (greater than 33 repeats) of which result in spinocerebellar ataxia-2 (SCA2), an autosomal dominant form of olivopontocerebellar atrophy. The gene for spinocerebellar ataxia type 2(SCA2) has been mapped to 12q24.1. Ataxin-2 associates with L- and T-plastin and overexpression leads to accumulation of T-plastin in mammalian cells.

Ataxin- 3 (Phospho- Ser256) Antibody

ABF8242 100 ug
EUR 525.6

Rat Ataxin 3(ATXN3) ELISA kit

E02A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit

E02A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit

E02A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ataxin 3(ATXN3) ELISA kit

E01A9913 96T
EUR 700
Description: ELISA

Pig Ataxin 3(ATXN3) ELISA kit

E07A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit

E07A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ataxin 3(ATXN3) ELISA kit

E07A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit

E08A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit

E08A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ataxin 3(ATXN3) ELISA kit

E08A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit

E01A44832 96T
EUR 700
Description: ELISA

Goat Ataxin 3(ATXN3) ELISA kit

E06A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit

E06A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ataxin 3(ATXN3) ELISA kit

E06A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ataxin 3 Rabbit Monoclonal Antibody

E10G22260 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Ataxin-3-Like Protein (ATXN3L) Antibody

abx230742-100ug 100 ug
EUR 577.2

Ataxin-3-Like Protein (ATXN3L) Antibody

abx230743-100ug 100 ug
EUR 610.8

Ataxin-3-Like Protein (ATXN3L) Antibody

abx230742-100g 100 µg
EUR 350

Ataxin-3-Like Protein (ATXN3L) Antibody

abx230743-100g 100 µg
EUR 350

Mouse Ataxin 3(ATXN3) ELISA kit

E01A18655 96T
EUR 700
Description: ELISA

Human Ataxin 3(ATXN3) ELISA kit

E01A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit

E01A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit

E01A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ataxin 3(ATXN3) ELISA kit

E01A1150 96T
EUR 700
Description: ELISA

Mouse Ataxin 3(ATXN3) ELISA kit

E03A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit

E03A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ataxin 3(ATXN3) ELISA kit

E03A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep Ataxin 3(ATXN3) ELISA kit

E01A97125 96T
EUR 700
Description: ELISA

Human Ataxin 3 (ATXN3) ELISA Kit

EKU12018-48T 48T
EUR 555.66

Human Ataxin 3 (ATXN3) ELISA Kit

EKU12018-5x96T 5x96T
EUR 3770.55

Human Ataxin 3 (ATXN3) ELISA Kit

EKU12018-96T 96T
EUR 793.8

Mouse Ataxin- 3, Atxn3 ELISA KIT

ELI-11387m 96 Tests
EUR 1038

Human Ataxin- 3, ATXN3 ELISA KIT

ELI-11466h 96 Tests
EUR 988.8

Human Ataxin 3 (ATXN3) ELISA Kit

EKN53129-48T 48T
EUR 345.73

Human Ataxin 3 (ATXN3) ELISA Kit

EKN53129-5x96T 5x96T
EUR 2346.03

Human Ataxin 3 (ATXN3) ELISA Kit

EKN53129-96T 96T
EUR 493.9

Human Ataxin 3(ATXN3)ELISA Kit

QY-E01558 96T
EUR 433.2

ATXN3 Ataxin-3 Human Recombinant Protein

PROTP54252 Regular: 10ug
EUR 380.4
Description: ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-370 a.a.) and having a molecular mass of 42.4kDa.;ATXN3 is purified by proprietary chromatographic techniques.

Canine Ataxin 3(ATXN3) ELISA kit

E01A62267 96T
EUR 700
Description: ELISA

Monkey Ataxin 3(ATXN3) ELISA kit

E01A70979 96T
EUR 700
Description: ELISA

Rabbit Ataxin 3(ATXN3) ELISA kit

E01A27400 96T
EUR 700
Description: ELISA

Bovine Ataxin 3(ATXN3) ELISA kit

E01A79696 96T
EUR 700
Description: ELISA

Rabbit Ataxin 3(ATXN3) ELISA kit

E04A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit

E04A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Ataxin 3(ATXN3) ELISA kit

E04A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit

E09A1769-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit

E09A1769-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Ataxin 3(ATXN3) ELISA kit

E09A1769-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey Ataxin 3(ATXN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)

20-abx303178
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  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Porcine Ataxin 3(ATXN3) ELISA kit

E01A53549 96T
EUR 700
Description: ELISA

Chicken Ataxin 3(ATXN3) ELISA kit

E01A88422 96T
EUR 700
Description: ELISA

Chicken Ataxin- 3, ATXN3 ELISA KIT

ELI-24058c 96 Tests
EUR 1113.6

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)

abx303178-100g 100 µg
EUR 362.5

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)

abx303178-20g 20 µg
EUR 162.5

Ataxin 3 / ATX3 (ATXN3) Antibody (HRP)

abx303178-50g 50 µg
EUR 250

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)

20-abx303179
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  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)

abx303179-100g 100 µg
EUR 362.5

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)

abx303179-20g 20 µg
EUR 162.5

Ataxin 3 / ATX3 (ATXN3) Antibody (FITC)

abx303179-50g 50 µg
EUR 250
Conclusions: Our examine factors to molecular mechanisms of SCA1 linked from each mobile and animal fashions and suggests medication that could possibly be examined to find out whether or not they have an effect on the aggregation of pathogenic ATXN1 and SCA1 illness development.

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