Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

Posted on December 23, 2020Categories Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Enzymes, Equipments, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, RNATags , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,   Leave a comment on Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

The RNA-binding protein Ataxin-2 binds to and stabilizes numerous mRNA sequences, together with that of the transactive response DNA binding protein 43 kDa (TDP-43). Ataxin-2 is moreover concerned in a number of processes requiring translation corresponding to germline formation, long run habituation and circadian rhythm formation. Nevertheless, it has but to be unambiguously demonstrated that Ataxin-2 is definitely concerned in activating the interpretation of its goal mRNAs. Right here we offer direct proof from a polysome profile evaluation displaying that Ataxin-2 enhances translation of … Continue reading “Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation”